NewsRelease

NewJersey Commission On Science, Innovation And Technology Phase IICatalyst Research Grant Awardedto Biotech Support Group

MONMOUTHJUNCTION, NJ,March31, 2025 -- Biotech Support Group announces receipt of a NEW JERSEYCOMMISSION ON SCIENCE, INNOVATION AND TECHNOLOGY Phase II CatalystResearch Award of $40,000. TheResearch Award entitled “Evaluatingthe NRicher™ Bead Platform for Targeted LC-MS Quantification”will be conducted at TheRutgers Biological Mass Spectrometry Facility. Thisaward follows from the Catalyst Phase I Award demonstrating simpleworkflows that generate low abundance enrichment of sub-proteomessuitable for quantitative plasma proteomics.

Background

TheNRicher™ platform began 15 years ago, as a non-biological poroussilica bead-based technology with a goal to differentially enrichsub-proteomes from complex proteomes. From this platform, severalcommercial products were derived, notably AlbuVoid™ and HemoVoid™that are now well established in the field. Following our lead, overthe last few years, other products have been commercialized dedicatedto enhancing proteome coverage, especially from biofluids like blood. 

Purposeof the Research

Whilecoverage remains an important aspect for discovery proteomics usingliquid chromatography coupled to mass spectrometry (LC-MS), fortargetedproteomics there are different sample prep demands. In targetedproteomics, specific proteins of interest have already beenpre-identified, either through initial discovery efforts, or selectedfrom gene expression and published data. Once selected, what thenbecomes necessary is more precise quantification of thepre-identified targets in robust cost-effective workflows, so as toconfirm validity and potential utility as biomarkers.

Consequently,targeted proteomics is emerging as a compelling alternative totraditional antibody-based methods for potential diagnostic andclinical utility. Nevertheless, the precise measurement of specifictarget peptides remains a significant challenge. Co-eluting peptidesfrom non-targets can generate ions similar to the targeted peptide,as well as suppress ionization. These interferences lead tochallenges in distinguishing and accurately quantifying the intendedtarget signal amid background non-target noise. This is especiallyproblematic for low abundance peptides from complex biologicalsamples like blood plasma. A simple sample prep that can enrichspecific protein(s) of interest in targeted proteomic workflows istherefore highly desirable.

Towardsthis goal, the research supported by this grant will allow us toinvestigate up to 10 different NRicher™ bead chemistries, surveyingthe full LC-MS signal intensity landscape of the plasma proteome.With a vision towards moving beyond strict protein abundancemeasurements, we intend to dedicate a significant portion of theresearch towards target peptides that report functional,post-translational and mutational variant regions that mightotherwise be overlooked due to signal to noise complexity. Suchregions promise actionable insights into disease and personalizedmedical decisions, not possible with other ‘omic’ analyses.

“Wedeeply appreciate the commitment from the State of New Jersey, toadvance bioscience innovations. This award accelerates our NRicher™platform to a next generation of products. These will feature all thecombined beneficial attributes from our current products: they areall consumable, are species agnostic, have enriched sub-proteomeswith functional integrity, and for LC-MS, digestion can be performedon-bead, without the use of detergents, for simplified and seamlessworkflows. All these benefits will be focused on improving targetedproteomic sample prep”, states Dr. Swapan Roy, Ph.D., President andFounder of Biotech Support Group.

Clickhere for more information on all of our Albumin & IgG Removalproducts

Clickhere for more information on all of our Hemoglobin Removal products

Clickhere for more information on our NRicher™ products

Keywords:Low Abundance Protein Enrichment, NRicher™, quantitativeproteomics, plasma proteomics, targeted proteomics, ParallelReaction Monitoring (PRM), Selected Reaction Monitoring (SRM), LC-MSproteomics, proteomic biomarkers

AboutBiotech Support Group LLC

Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for expanding proteomic analysis.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area. For this market, keyproducts include: AlbuVoid™ and AlbuSorb™ PLUS foralbumin & IgG depletion, Cleanascite™for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobinremoval, and NRicher™ for low abundance targeted proteomics, andfamily specific sub-proteome enrichment. For more information, go tohttp://www.biotechsupportgroup.com

Forbusiness development contact: Matthew Kuruc
732-274-2866[email protected]