Functional proteomics relies in part, on the functional or structural features of intact, non-denatured proteins. While the terminology can often overlap, chemical and affinity-based proteomic profiles can be considered a subset of functional proteomics. Thus, functional proteomic annotation may complement conventional sequence annotation while supporting the study of mechanism of action and drug promiscuity. Furthermore, the subtleties of protein attributes, when the same or similar underlying sequence can have multiple conformations and functions, and when different sequences sometime perform the same or similar functions, are now open to investigation. A new functional proteomics separations toolset based on the NuGel™ passivated porous silica platform, can be used in unrestricted workflow strategies, so as to sift through these biological complexities.
