Albumin Depletion

AlbuSorb™ Albumin Depletion Kit

Intestinal Organoid Supernatants

Jordan, Christine KI, et al. "Symbiotic Firmicutes establish mutualism with the host via innate tolerance and resistance to control systemic immunity.." Cell Host & Microbe (2023).

Intestinal Organoid Supernatants

Matsuzawa-Ishimoto, Yu, et al. "The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.." Nature (2022): 1-8.

Human serum

High-throughput, Automated INTip™ SPE Combined with AlbuSorb™ Products for Efficient Albumin and Albumin/IgG Depletion

Matthew Fitts 1; William E. Kemnitzer 1; Paul Meeh 1; Matt Kuruc 2; Swapan Roy 2; Sowmya Avadhani 2 1DPX Technologies, Columbia, SC; 2Biotech Support Group LLC, Monmouth Junction, NJ Corresponding Author: mkuruc@biotechsupportgroup.com

Clarified serum

A Preliminary Investigation Using Targeted LC-MS Proteomic Methods Demonstrates Unique Serum Profiles of Hospitalized SARS-CoV-2 Patients

Douglas D Fraser 1; Haiyan Zheng 2; Swapan Roy 3; Matt Kuruc 3; Amenah Soherwardy 2; Devjit Roy 4; Sowmya Avadhani 3 1Lawson Research Institute, London, Ontario; 2Rutgers University Proteomics Center, Piscataway, New Jersey; 3Biotech Support Group LLC, Monmouth Junction, NJ; 4Nathan Littauer Hospital, Gloversville, New York Corresponding Author : mkuruc@biotechsupportgroup.com

Whole blood, serum and plasma samples

DPX Technologies and Biotech Support Group Announce In-Market Partnership for High Throughput Proteomic Sample Prep

Serum Exosomes

Valladolid-Acebes, Ismael, et al."Lowering apolipoprotein CIII protects against high-fat diet–induced metabolic derangements.."  Science Advances 7.11 (2021): eabc2931.

Serum Exosomes

Chettimada, Sukrutha, et al. "Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy." Scientific Reports 8.1 (2018): 7227.

Cerebrospinal Fluid

Gwenael Pottiez, Pawel Ciborowski. Proteomic Profiling of Cerebrospinal Fluid Expression Profiling In Neuroscience Neuromethods.2012;64:245-270

Synovial fluid

Happonen KE, Fürst CM, Saxne T et al. PRELP protein inhibits the formation of the complement membrane attack complex . Journal of Biological Chemistry.2012;287(11):8092-100

Serum

Vialaret, Jerome & Kadi, Sarah & Tiers, Laurent & O Flynn, Robin & Lehmann, Sylvain & Hirtz, Christophe. (2018). "Albumin depletion of human serum to improve quantitative clinical proteomics." Current Topics in Peptide & Protein Research 19. 53-62.

Roy, Swapan, and Matthew Kuruc. "Methods to Monitor the Functional Subproteomes of SERPIN Protease Inhibitors. Functional Proteomics. Humana Press, New York, NY, 2019. 41-54

Berggren, Per-olof, and Lisa Juntti-berggren. "Methods for treating and/or limiting development of diabetes." U.S. Patent No. 20,170,037,118. 9 Feb. 2017 .MOJ Proteomics Bioinform 2016, 3(6): 00106

Swapan Roy, Matthew Kuruc. The Functional Subproteomes of Serpin Protease Inhibitors are Now Open for LC-MS Biomarker Discovery .MOJ Proteomics Bioinform 2016, 3(6): 00106

Holmberg R, Refai E, Höög A. Lowering apolipoprotein CIII delays onset of type 1 diabetes . Proceedings of the National Academy of Sciences.2011;108(26):10685-9.

Tang MX, Ogawa K, Asamoto M. Effects of Nobiletin on PhIP-Induced Prostate and Colon Carcinogenesis in F344 Rats Nutrition and Cancer.2011;63(2):227-33

Holmberg, Rebecka Apolipoprotein CIII and Ljungan virus in diabetes 2010. Doctoral Thesis

Lu Q, Zheng X, McIntosh T Development of different analysis platforms with LC-MS for pharmacokinetic studies of protein drugs . Analytical Chemistry.2009;81(21):8715-23

Urine

Zubiri, Irene, et al. " Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis ." Journal of proteomics 96 (2014): 92-102.

Patent

Berggren, Per Olaf, Yang, Shao-Nian. 2012. Methods For Treating And/Or Limiting Development Of Diabetes . U.S. Patent 20120328630 Kind Code: A1, filed June 25, 2012, and issued December 27, 2012.

AlbuTrial™ Kit - AlbuVoid™ and AlbuSorb™

Cerebrospinal Fluid

Gwenael Pottiez, Pawel Ciborowski. Proteomic Profiling of Cerebrospinal Fluid Expression Profiling In Neuroscience Neuromethods.2012;64:245-270

Synovial fluid

Happonen KE, Fürst CM, Saxne T et al. PRELP protein inhibits the formation of the complement membrane attack complex . Journal of Biological Chemistry.2012;287(11):8092-100

Serum

Holmberg R, Refai E, Höög A. Lowering apolipoprotein CIII delays onset of type 1 diabetes. Proceedings of the National Academy of Sciences.2011;108(26):10685-9.

Tang MX, Ogawa K, Asamoto M. Effects of Nobiletin on PhIP-Induced Prostate and Colon Carcinogenesis in F344 Rats Nutrition and Cancer.2011;63(2):227-33

Holmberg, Rebecka Apolipoprotein CIII and Ljungan virus in diabetes 2010. Doctoral Thesis

Lu Q, Zheng X, McIntosh T Development of different analysis platforms with LC-MS for pharmacokinetic studies of protein drugs . Analytical Chemistry.2009;81(21):8715-23

AlbuVoid™ References

Conditioned media

Paulsen, Bruna, et al."Reproducible differentiation of pure ovarian support cells from clinical-grade hiPSCs as a novel infertility treatment." bioRxiv  (2024): 2024-04.

Tumor-stroma ratio

Polack, M., et al. "Results from the UNITED study: a multicenter study validating the prognostic effect of the tumor–stroma ratio in colon cancer." ESMO open 9.4 (2024): 102988.

Plasma

Sae-Lee, Wisath, et al. " The protein organization of a red blood cell ." Cell Reports 40.3 (2022): 111103.

Culture Supernatants Cell Secretome Proteome Analysis

Jenull, Sabrina, et al. "The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence." Cell Reports 36.3 (2021): 109406.

Osteogenic and Fibrogenic Blood Composites

Jing, Lun, et al. "PROTEOMIC ANALYSIS IDENTIFIED LBP AND CD14 AS KEY PROTEINS IN BLOOD/BIPHASIC CALCIUM PHOSPHATE MICROPARTICLE INTERACTIONS." Acta Biomaterialia, (2021).

Blood

Targeted LC-MS Proteomic Methods to Monitor and Quantify Stromal Conditioning in Cancer from Blood
Matt Kuruc1; Swapan Roy1; Wilma Mesker2; Rob Tollenaar2; 1Biotech Support Group LLC, Monmouth Junction, NJ; 2Leiden University Medical Center, Leiden, Netherlands

Blood

Kuruc M, Zheng H, Sowerhardy A, Avadhani S, Roy D, et al.(2020) "New Strategies to Categorize Blood for Proteomic Biomarker Discovery." Proteomics Bioinformatics, 2(2): 90-107.

Biotech Support Group to exhibit at the 67th ASMS Conference on Mass Spectrometry & Allied Topics .

Application Report

Haiyan Zheng 1; Swapan Roy 2; Devjit Roy MD 2; Amenah Soherwardy 1; Seema Rathman 2; Matthew Kuruc 2 1Rutgers Center for Integrative Proteomics, Piscataway, NJ; 2Biotech Support Group LLC, Monmouth Junction, NJ Stroma Liquid Biopsy – Pan-Cancer Dysregulation of the Serum Proteome

Serum

Vialaret, Jerome & Kadi, Sarah & Tiers, Laurent & O Flynn, Robin & Lehmann, Sylvain & Hirtz, Christophe." Albumin depletion of human serum to improve quantitative clinical proteomics. ."Current Topics in Peptide & Protein Research 19. 53-62.

Roy, Swapan, and Matthew Kuruc. " Methods to Monitor the Functional Subproteomes of SERPIN Protease Inhibitors. ."Functional Proteomics. Humana Press, New York, NY, 2019. 41-54

Vialaret, Jerome, et al. " Albumin depletion of human serum to improve quantitative clinical proteomics. ."

Poillet-Perez, Laura, et al. " Autophagy maintains tumour growth through circulating arginine. ." Nature (2018): 1.

David L. Wang, Chuanguang Xiao, Guofeng Fu, Xing Wang and Liang Li. " Identification of potential serum biomarkers for breast cancer using a functional proteomics technology. ." Biomarker Research (2017) 5:11.. DOI 10.1186/s40364-017-0092-9

Sun, Zhenyu, Xiaofeng Chen, Gan Wang, Liang Li, Guofeng Fu, Matthew Kuruc, and Xing Wang. " Identification of functional metabolic biomarkers from lung cancer patient serum using PEP technology ." Biomarker Research 4, no. 1 (2016): 1.

Haiyan Zheng; Caifeng Zhao; Swapan Roy; Devjit Roy MD; Amenah Soherwardy; Ravish Amin; Matthew Kuruc. Application Report - The Comparison of the Serum Proteome in Individuals with Cancers versus those without Cancer, and its application to Wellness

Dr.Swapan Roy; Amenah Soherwardy; Ravish Amin; Matthew Kuruc.Monmouth Junction, NJ - Application Report. AlbuSorb™ Product Extension combines Albumin and Immunoglobulin Depletion in a Consumable Format

Xing Wang, Michael Davies, Swapan Roy and Matthew Kuruc. Bead Based Proteome Enrichment Enhances Features of the Protein Elution Plate (PEP) for Functional Proteomic Profiling . Proteomes 2015, 3(4), 454-466. doi: 10.3390/proteomes3040454

Grubbs, J. K., et al. " Investigation of the efficacy of albumin removal procedures on porcine serum proteome profile1 ." (2015).

Discovery of Functional Serum Biomarkers Using AlbuVoid™ Enrichment and the ArrayBridge PEP Profiling Platform . Personal communication, Xing Wang, Ph.D., ArrayBridge (St. Louis, MO), manuscripts in process.

Serum Profiling Making Mark on Predictive Medicine

Vicki Glaser.Genetic Engineering & Biotechnology News. 2011;31(7):1-55.

Kuruc Matt. Application Report - AlbuVoid™ & On-Bead Digestion - Tackling the challenges of serum proteomics (LC-MS).

Kuruc Matt, Dr.Roy. Application Report - AlbuVoid™ LC-MS On-Bead – Differential Expression of Cancer Sera Proteins Using Quantitative (iTRAQ) Proteomics

Patents

Narain, Niven Rajin, Rangaprasad Sarangarajan, and Vivek K. Vishnudas. " "Interrogatory cell- based assays for identifying drug-induced toxicity markers. ." U.S. Patent Application No. 16/180,446.

Narain, Niven Rajin, Rangaprasad Sarangarajan, and Vivek K. Vishnudas. " INTERROGATORY CELL-BASED ASSAYS AND USES THEREOF ." U.S. Patent No. 20,120,258,874. 11 Oct. 2012.

Plasma

Espes, Daniel, Joey Lau, and Per-Ola Carlsson. " Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes ." Diabetologia(2013): 1-4.

Patent - Secretome Sample Preparation

Narain, Niven Rajin, and Paula Patricia Narain. " COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDER ." U.S. Patent No. 20,150,023,949. 22 Jan. 2015.

Narain, Niven Rajin, Rangaprasad Sarangarajan, and Vivek K. Vishnudas. " INTERROGATORY CELL-BASED ASSAYS AND USES THEREOF ." U.S. Patent No. 20,120,258,874. 11 Oct. 2012.

Cell Culture

Narain, Niven Rajin, Rangaprasad Sarangarajan, Vivek K. Vishnudas, and Michael Andrew Kiebish. " USE OF MARKERS IN THE IDENTIFICATION OF CARDIOTOXIC AGENTS AND IN THE DIAGNOSIS AND MONITORING OF CARDIOMYOPATHY AND CARDIOVASCULAR DISEASE ." U.S. Patent 20,140,100,128, issued April 10, 2014.

On-Bead Digestion Protocols For LC-MS Proteomic Workflows

New on-bead digestion for LC-MS applications for proteomic studies

US HUPO 2014. Frontiers in Proteomics: Advancing Biology through Technology and Computation.

AlbuVoid™ poster, entitled " Improved proteomic enrichment and workflow strategies ", poster board 089 presented at US HUPO 2014

AlbuSorb™ PLUS

Plasma samples

Grantz, Jillian M., et al.""The platelet and plasma proteome and targeted lipidome in postpartum dairy cows with elevated systemic inflammation."" Scientific Reports 14.1 (2024): 31240.

Whole blood, serum and plasma samples

DPX Technologies and Biotech Support Group Announce In-Market Partnership for High Throughput Proteomic Sample Prep

Serum/Plasma Samples

Biotech Support Group & Lawson Health Research Institute Enter Collaborative Research Agreement to Monitor Protease Inhibitor Function During Covid-19 Infections

Serum

Thangavelu, Bharani, et al. "Dataset of Rat and Human Serum Proteomes Derived from Differential Depletion Strategies prior to Mass Spectrometry." Data in Brief (2020): 105657.

Application Report

AlbuVoid™ PLUS & AlbuSorb™ PLUS - Evaluating Different Windows of Observation Solves The Many Challenges of Serum Proteomics

AlbuSorb™ Product Extension combines Albumin and Immunoglobulin Depletion in a Consumable Format

AlbuVoid™ PLUS - Albumin and IgG Depletion From Serum/Plasma for Proteomics

References

AlbuVoid™ PLUS & AlbuSorb™ PLUS - Evaluating Different Windows of Observation Solves The Many Challenges of Serum Proteomics

Zheng H, Soherwardy A, Roy S, Kuruc M, Avadhani S. AlbuVoid™ Enrichment & Antibody Depletion – Tackling the Challenges of Serum Proteomics Part II. Poster reprint first presented at 26th International Molecular Med TRI-CON, March 10-15, 2019, San Francisco, CA USA

Vialaret, Jerome & Kadi, Sarah & Tiers, Laurent & O Flynn, Robin & Lehmann, Sylvain & Hirtz, Christophe. (2018). Albumin depletion of human serum to improve quantitative clinical proteomics. Current Topics in Peptide & Protein Research 19. 53-62.

Poillet-Perez, Laura, et al. "Autophagy maintains tumour growth through circulating arginine." Nature (2018): 1.

Roy, Swapan, and Matthew Kuruc. "Methods to Monitor the Functional Subproteomes of SERPIN Protease Inhibitors." Functional Proteomics. Humana Press, New York, NY, 2019. 41-54.

Mihara, Keisuke, et al. "Identification of Specific Protein Markers of Rheumatoid Arthritis in Synovial Fluid and Serum." Journal of Hard Tissue Biology 27.1 (2018): 55-58.

David L. Wang, Chuanguang Xiao, Guofeng Fu, Xing Wang and Liang Li. Identification of potential serum biomarkers for breast cancer using a functional proteomics technology. Biomarker Research (2017) 5:11. DOI 10.1186/s40364-017-0092-9

Zheng, H., et al. "AlbuVoid™ coupled to on-bead digestion-tackling the challenges of serum proteomics." J Proteom Bioinformatics 8.9 (2015): 225.

Zheng, H., et al. Poster reprint first presented at 14th Human Proteome Organization World Congress (HUPO 2015), held on September 27 – 30, 2015 entitled “New Proteomic Workflows Combine Albumin Depletion and On Bead Digestion, for Quantitative Cancer Serum”.

AlbuVoid™ LC-MS On-Bead For Serum Proteomics

Serum

Haiyan Zheng, Caifeng Zhao, Meiqian Qian, Swapan Roy, Absari Arpa, Amenah Soherwardy and Matthew Kuruc. AlbuVoid™ Coupled to On-Bead Digestion - Tackling the Challenges of Serum Proteomics. J Proteomics Bioinform 2015, 8:9.

Grubbs, J. K., et al. " Investigation of the efficacy of albumin removal procedures on porcine serum proteome profile1." (2015).

Discovery of Functional Serum Biomarkers Using AlbuVoid™ Enrichment and the ArrayBridge PEP Profiling Platform.Personal communication, Xing Wang, Ph.D., ArrayBridge (St. Louis, MO), manuscripts in process.

Serum Profiling Making Mark on Predictive Medicine
Vicki Glaser.Genetic Engineering & Biotechnology News. 2011;31(7):1-55.

Kuruc Matt, Dr.Roy. Application Report - AlbuVoid™ LC-MS On-Bead – Differential Expression of Cancer Sera Proteins Using Quantitative (iTRAQ) Proteomics

Plasma
Espes, Daniel, Joey Lau, and Per-Ola Carlsson. "Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes." Diabetologia(2013): 1-4.

Patent - Secretome Sample Preparation
Narain, Niven Rajin, and Paula Patricia Narain. "COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDER." U.S. Patent No. 20,150,023,949. 22 Jan. 2015.

Narain, Niven Rajin, Rangaprasad Sarangarajan, and Vivek K. Vishnudas. " INTERROGATORY CELL-BASED ASSAYS AND USES THEREOF." U.S. Patent No. 20,120,258,874. 11 Oct. 2012.

Cell Culture
Narain, Niven Rajin, Rangaprasad Sarangarajan, Vivek K. Vishnudas, and Michael Andrew Kiebish. "USE OF MARKERS IN THE IDENTIFICATION OF CARDIOTOXIC AGENTS AND IN THE DIAGNOSIS AND MONITORING OF CARDIOMYOPATHY AND CARDIOVASCULAR DISEASE." U.S. Patent 20,140,100,128, issued April 10, 2014.

On-Bead Digestion Protocols For LC-MS Proteomic Workflows
New on-bead digestion for LC-MS applications for proteomic studies

US HUPO 2014. Frontiers in Proteomics: Advancing Biology through Technology and Computation.

AlbuVoid™ abstract entitled "Improved proteomic enrichment and workflow strategies", poster board 089 presented at US HUPO 2014

AlbuTrial™ PLUS Kit

Hemoglobin Depletion

NuGel-HemogloBind™ - Hemoglobin Capture Reagent From Blood and Hemolyzed Serum

Tumor Interstitial Fluid

Zhang, X., Li, S., Malik, I. et al. "Reprogramming tumour-associated macrophages to outcompete cancer cells." Nature (2023).

Whole blood, serum and plasma samples

DPX Technologies and Biotech Support Group Announce In-Market Partnership for High Throughput Proteomic Sample Prep

Whole blood

Leitner, Dominique F., et al."Metabolomic, Proteomic, and Transcriptomic Changes in Adults with Epilepsy on Modified Atkins Diet." Epilepsia (2023).

HemogloBind™ - Hemoglobin Depletion From Hemolyzed Serum/Plasma

Fresh frozen human EDTA-whole Blood

de Boni, Laura, et al. "Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients." EMBO Molecular Medicine (2024): 1-18.

EDTA Whole Blood (EWB)

Das, Amaresh, et al."Enhanced Recovery and Detection of Highly Infectious Animal Disease Viruses by Virus Capture Using Nanotrap® Microbiome a Particles." (2024).

Hemolyzed Samples

Neil Adrian P. Ondevilla, Peng-Wen Liu, Wan-Ting Huang, Tzu-Ping Weng, Nan-Yao Lee, Syu-Cing Ma, Jian-Jang Huang, Tak-Wah Wong, Hsien-Chang Chang,"A point-of-care electrochemical biosensor for the rapid and sensitive detection of biomarkers in murine models with LPS-induced sepsis" Biosensors and Bioelectronics, Volume 254, 2024, 116202, ISSN 0956-5663,

Pooled Blood Samples

Igoh, Akihisa, Masanobu Miura, and Satoru Miyaishi."Animal Species and Blood Identification with Peptide Mass Fingerprinting." Analytical Chemistry (2024).

RBC lysates

Chen, Yaozhen, et al."Noncanonical NLRP3 Inflammasome Activation Elicits the Programmed Death of Red Blood Cells." Available at SSRN 4626203.

Abdominal Aneurysm Samples

Jara, Zaira Palomino, et al."Distinct Mechanisms of β-Arrestin–Biased Agonist and Blocker of AT1R in Preventing Aortic Aneurysm and Associated Mortality." Hypertension 80.2 (2023): 385-402.

Peripheral blood mononuclear cell (PBMC) whole cell lysate samples

Kaneko, Tomonori, et al."Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients." (2023).

Red blood cells

Barakat, Amey, et al."Effects of 2,3-DPG knockout on SCD phenotype in Townes SCD model mice" American Journal of Hematology (2023).

Mouse Red Blood Cells 

Zhan, Jing, et al."Silica nanoparticles trigger phosphatidylserine exposure in red blood cells and induce thrombosis risk." Environmental Pollution (2023): 121591.

Hemolysate 

Dasauni, Pushpanjali, et al."Optimization and Identification of Single Mutation in Hemoglobin Variants with 2, 2, 2 Trifluoroethanol Modified Digestion Method and Nano− LC Coupled MALDI MS/MS." Molecules 27.19 (2022): 6357.

Whole Blood Sample

Witchey, Shannah K., et al. ""Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats."" Toxicological Sciences (2022).

Hemolysate Preparations Remnant White Ghosts

Sae-Lee, Wisath, et al. " The protein organization of a red blood cell ." Cell Reports 40.3 (2022): 111103.

Plasma Samples

Phillippi, Danielle T., et al. "Inhaled diesel exhaust particles result in microbiome-related systemic inflammation and altered cardiovascular disease biomarkers in C57Bl/6 male mice." Particle and fibre toxicology 19.1 (2022): 1-29.

Human serum

High-throughput, Automated INTip™ SPE Combined with AlbuSorb™ Products for Efficient Albumin and Albumin/IgG Depletion Matthew Fitts 1; William E. Kemnitzer 1; Paul Meeh 1; Matt Kuruc 2; Swapan Roy 2; Sowmya Avadhani 2 1DPX Technologies, Columbia, SC; 2Biotech Support Group LLC, Monmouth Junction, NJ Corresponding Author: mkuruc@biotechsupportgroup.com

Urine Samples

Juriasingani, Smriti, et al. "Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion." International Journal of Molecular Sciences 22.13 (2021): 7180.

Lysed RBCs

D'Alessandro, Angelo, et al. "Hematologic and systemic metabolic alterations due to Mediterranean type II G6PD deficiency in a novel murine model." bioRxiv (2021).

Hemolyzed Red Blood Cells Biological Fluids

Heather E. McKiernan, Phillip B. Danielson, Catherine O. Brown, Masha Signaevsky, Christian G. Westring and Kevin M. Legg, Developmental Validation of a Multiplex Proteomic Assay for the Identification of Forensically Relevant Biological Fluids, Forensic Science International, (2021)

Peripheral blood derived mononuclear cells whole cell lysate samples

Kaneko, Tomonori, et al."System-wide hematopoietic and immune signaling aberrations in COVID-19 revealed by deep proteome and phosphoproteome analysis." Research Square preprint (2021).

Blood cell lysates

Yamagishi, Yoshikazu, Hirotaro Iwase, and Yasumitsu Ogra."Post-Mortem Changes of Methomyl in Blood with Hemoglobin." Chemical Research in Toxicology.

Reticulocytes (Retics) lysates

Hojo-Souza NS, de Azevedo PO, de Castro JT, Teixeira- Carvalho A, Lieberman J, et al "Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage." PLOS Pathogens 16(9): e1008840.

Blood

Southwell, Rebecca Marie, Kenneth Sherlock, and Matthew Baylis. "Cross-sectional study of British wild deer for evidence of Schmallenberg virus infection." Veterinary Record (2020).

Application Reports

Hemoglobin Removal Whitepaper Describes a Range of Depletion Strategies and Their Successful Uses

“Hemoglobin Removal - The Gold Standard Products”, April 28, 2020

ebook Describes the Role of the Innate Immunity Proteome As a Central Modulator of Disease from Pandemic Infections to Cancer
“Categorization of Blood Based Biomarkers – Unleashing the Power of Proteomics To Better Understand the Innate Immune Response to Infectious and Non-infectious Inflammatory Stimuli”, April 17, 2020

Host red blood cells

Dziekan, Jerzy Michal, et al. "Cellular thermal shift assay for the identification of drug–target interactions in the Plasmodium falciparum proteome." Nature Protocols(2020): 1-41.

Hemolyzed Serum

Craig, J. R., et al. "A comparison of the anatomical and gastrointestinal functional development between gilt and sow progeny around birth and weaning." Journal of animal science (2019).

Reticulocytes

Nguyen, Anthony T., et al. "UBE2O remodels the proteome during terminal erythroid differentiation." Science 357.6350 (2017): eaan0218.

Perfusates

Laing, Richard W., et al. "The use of an acellular oxygen carrier in a human liver model of normothermic machine perfusion." Transplantation 101.11 (2017): 2746.

Hemocyte fractions

O’Connell, Grant C., et al. "Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following ischemic stroke." Scientific reports 7.1 (2017): 12940.

Hemolysate

Dasauni, Pushpanjali, et al. "Refractive index of blood is a potential qualitative indicator of hemoglobin disorder in humans." Journal of Proteins & Proteomics 9.3 (2018).

Cell Lysates Of Reticulocytes

Junqueira, Caroline, et al. "Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax–infected reticulocytes." Nature medicine (2018): 1.

Whole Blood Aliquots

Pácal, Lukáš, et al. "Deleterious Effect of Advanced CKD on Glyoxalase System Activity not Limited to Diabetes Aetiology." . International Journal of Molecular Sciences 19.5 (2018): 1517.

Bronchoalveolar lavage fluid (BALF)

Maneesh Bhargava, Kevin J. Viken, Sanjoy Dey, Michael S. Steinbach, Baolin Wu, Pratik D. Jagtap, LeeAnn Higgins, Angela Panoskaltsis-Mortari, Daniel J. Weisdorf, Vipin Kumar, Mukta Arora, Peter B. Bitterman, David H. Ingbar, Chris H. Wendt. Proteome Profiling in Lung Injury after Hematopoietic Stem Cell Transplantation . Biology of Blood and Marrow Transplantation 22 (2016) 1383-1390.

Cell Lines

Phanse, Sadhna, Cuihong Wan, Blake Borgeson, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong et al. " Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes ." Data in brief 6 (2016): 715-721.

Dried Blood Spot(DBS)/Whole Blood

Hakuna, Lovemore, et al. " A simple assay for glutathione in whole blood ."Analyst (2015).

Whole Blood

Chalásová, Katarína, et al. "Transketolase Activity but not Thiamine Membrane Transport Change in Response to Hyperglycaemia and Kidney Dysfunction ." Experimental and Clinical Endocrinology & Diabetes (2017).

Chalásová, Katarína. Functional analysis of genetic variants in genes associated with the development of glycotoxic damage . Diss. Masarykova univerzita, Lékařská fakulta, 2017.

Lahut, Suna, et al. " Blood RNA biomarkers in prodromal PARK4 and REM sleep behavior disorder show role of complexin-1 loss for risk of Parkinson's disease. " Disease Models & Mechanisms (2017): dmm-028035.

Brittain, Matthew K., Kevin G. McGarry, Robert A. Moyer, Michael C. Babin, David A. Jett, Gennady E. Platoff, and David T. Yeung. " Efficacy of Recommended Prehospital Human Equivalent Doses of Atropine and Pralidoxime Against the Toxic Effects of Carbamate Poisoning in the Hartley Guinea Pig ." International journal of toxicology (2016): 1091581816638086.

Snider, Thomas H., Kevin G. McGarry, Michael C. Babin, David A. Jett, Gennady E. Platoff Jr, and David T. Yeung. " Acute toxicity of phorate oxon by oral gavage in the Sprague-Dawley rat ." Fundamental Toxicological Sciences 3, no. 5 (2016): 195-204.

Bhargava, Maneesh, Kevin J. Viken, Sanjoy Dey, Michael S. Steinbach, Baolin Wu, Pratik D. Jagtap, LeeAnn Higgins et al. " Proteome Profiling in Lung Injury after Hematopoietic Stem Cell Transplantation ." Biology of Blood and Marrow Transplantation (2016).

Snider, Thomas H., Christina M. Wilhelm, Michael C. Babin, Gennady E. Platoff Jr, and David T. Yeung. " Assessing the therapeutic efficacy of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig ."The Journal of Toxicological Sciences 40, no. 6 (2015): 759-775.

Blood Plasma

Johns, Michael, et al. "SR-135, a peroxynitrite decomposing catalyst, enhances β-cell function and survival in B6D2F1 mice fed a high fat diet. "Archives of Biochemistry and Biophysics (2015).

Asleh, Rabea, et al. " Haptoglobin Genotype-dependent Differences in Macrophage Lysosomal Oxidative Injury ." Journal of Biological Chemistry 289.23 (2014): 16313-16325.

Biological Fluids
J Krupey - United States Patent: 10/180,053, 2002 Removal of extraneous substances from biological fluids containing nucleic acids and the recovery of nucleic acids

Lung Tissue Specimens & Pulmonary Research (Acute Respiratory Distress Syndrome & Acute Hypoxic Failure)
Bhargava, Maneesh" "Proteomic Studies in Acute Hypoxic Respiratory Failure." PhD diss., UNIVERSITY OF MINNESOTA . (2015).

Red Blood Cell (RBC) - Lysates.
Kyoungsook Park, Christopher D. Saudek, and Gerald W. Hart Increased Expression of β-N-Acetylglucosamindase (O-GlcNAcase) in Erythrocytes from Prediabetic and Diabetic Individuals. Diabetes.2010;59(7):1845-50.

Barasa, Benjamin, and Monique Slijper. " Challenges for red blood cell biomarker discovery through proteomics ." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844.5 (2014): 1003-1010

Stored Blood Products
Delobel J., Rubin O., Prudent M., Crettaz D., Tissot J.-D., Lion N.(2010) Biomarker Analysis of Stored Blood Products: Emphasis on Pre-Analytical Issues . International Journal of Molecular Sciences. 11(11):4601-4617

Red Blood Cells/Forensic Research
Danielson, Phillip B. " Isolation of Highly Specific Protein Markers for the Identification of Biological Stains: Adapting Comparative Proteomics to Forensics. " (2011).

Red Blood Cells (RBC) - Blood.
Wilhelm, Christina M., et al. A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides. Toxicology and Applied Pharmacology Available online 31 October 2014. doi:10.1016/j.taap.2014.10.009

Hikosaka, Keisuke, et al. " Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocyte" Journal of Biological Chemistry (2014): jbc-M114.

McGarry, Kevin G., et al. " Evaluation of HemogloBind™ treatment for preparation of samples for cholinesterase analysis ." (2013). Advances in Bioscience and Biotechnology, 2013, 4, 1020-1023

Alvarez-Llamas, Gloria, Fernando de la Cuesta, Maria G. Barderas, Irene Zubiri, Maria Posada-Ayala, and Fernando Vivanco. " Characterization of Membrane and Cytosolic Proteins of Erythrocytes. " In Vascular Proteomics, pp. 71-80. Humana Press, 2013.

Alvarez-Llamas, G., de la Cuesta, F., Barderas, M. G., Darde, V. M., Zubiri, I., Caramelo, C., Vivanco, F. A novel methodology for the analysis of membrane and cytosolic sub-proteomes of erythrocytes by 2-DE. Electrophoresis.2009;30:4095-4108

Zihao Wang, Kyoungsook Park, Frank Comer1, Linda C. Hsieh-Wilson, Christopher D. Saudek, Gerald W. Hart. Site-Specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes Mellitus . Diabetes.2008;58, 309-317.

Datta, Pradip. Effect of Hemolysis, High Bilirubin, Lipemia, Paraproteins, and System Factors on Therapeutic Drug Monitoring . Handbook of Drug Monitoring Methods.2008; 97-109.

Yuichi Miki, Tomoki Tazawa, Kazuya Hirano, Hideki Matsushima, Shoko Kumamoto, Naotaka Hamasaki, Tomohiro Yamaguchi, Masatoshi Beppu. Clearance of oxidized erythrocytes by macrophages: Involvement of caspases in the generation of clearance signal at band 3 glycoprotein . Biochemical and Biophysical Research Communications.2007; 363(1):57-62

Sarawathi,et al., Relative quantification of glycated Cu-Zn superoxide dismutase in erythrocytes by electrospray ionization mass spectrometry , Biochimica et Biophysica Acta. 1999.1426(3):483-90

Bilirubin
Krishna, Neel K., and Kenji Cunnion. " Derivative Peptide Compounds and Methods of Use ." U.S. Patent No. 20,160,376,322. 29 Dec. 2016.

Person, N.B., Effect Of HemogloBind™ On Interference Reduction In Bilirubin Analysis.poster Clinichem, 1995.

Serum
Nishida-Aoki, Nao, et al. " Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis ." Molecular Therapy 25.1 (2017): 181-191.

Baion, C.M. & Ali, A.C. Evaluation Of HemogloBind™ For Removal Of O-Raffinose Crosslinked Hemoglobin (Hemolink™) From Serum , poster AACC Meeting 1997.

Tissue
Padilla, S., Convenient Method for Decreasing the Amount of Hemoglobin in Tissue Samples Without Affecting the Level of Cholinesterase Activity, unpublished personal correspondence, 1994.

HemoVoid™ References

Pooled Blood Samples
Igoh, Akihisa, Masanobu Miura, and Satoru Miyaishi."Animal Species and Blood Identification with Peptide Mass Fingerprinting." Analytical Chemistry (2024).

Red Blood Cells
Cao, Chan, et al. "Deep learning-assisted single-molecule detection of protein post-translational modifications with a biological nanopore." bioRxiv (2023): 2023-09.

Erythrocyte Lysate Samples
Das, Sonu, et al."A journey to unravel the pathophysiology of stable and exacerbated Chronic obstructive pulmonary disease through erythrocyte proteomics: A combined mass spectrometry/bioinformatics approach." (2022).

Blood Cell Proteins
Wu, Na, et al. "Proteomic characteristics of plasma and blood cells in natural aging rhesus monkeys." Proteomics: 2200049.

Jak2VF Red Blood Cells (RBC)
Liu, Wenli, et al."Erythroid lineage Jak2 V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis." The Journal of Clinical Investigation (2022).

Fasting Blood Samples
Wang, Jijun, et al."The D2R-DISC1 protein complex and associated proteins are altered in schizophrenia and normalized with antipsychotic treatment." Journal of Psychiatry and Neuroscience  47.2 (2022): E134-E147.

Blood

Pawliński, Łukasz, et al. "Proteomic biomarkers in Gaucher disease." Journal of clinical pathology 74.1 (2021): 25-29.

Osteogenic and Fibrogenic Blood Composites

Jing, Lun, et al. "PROTEOMIC ANALYSIS IDENTIFIED LBP AND CD14 AS KEY PROTEINS IN BLOOD/BIPHASIC CALCIUM PHOSPHATE MICROPARTICLE INTERACTIONS." Acta Biomaterialia, (2021).

RBC samples

Christer, M. A. L. M., et al. ""Methods for the detection of autologous blood-doping."" U.S. Patent Application No. 16/976,936.

Valentim-Coelho, Cristina, et al. ""Redox–Oligomeric State of Peroxiredoxin-2 and Glyceraldehyde-3-Phosphate Dehydrogenase in Obstructive Sleep Apnea Red Blood Cells under Positive Airway Pressure Therapy."" Antioxidants 9.12 (2020): 1184.

Blood

Pawliński, Łukasz, et al. "Proteomic biomarkers in Gaucher disease." Journal of Clinical Pathology (2020).

Application Reports

Hemoglobin Removal Whitepaper Describes a Range of Depletion Strategies and Their Successful Uses

“Hemoglobin Removal - The Gold Standard Products”, April 28, 2020

ebook Describes the Role of the Innate Immunity Proteome As a Central Modulator of Disease from Pandemic Infections to Cancer
“Categorization of Blood Based Biomarkers – Unleashing the Power of Proteomics To Better Understand the Innate Immune Response to Infectious and Non-infectious Inflammatory Stimuli”, April 17, 2020

Erythrocytes
Bollenbach, Alexander, et al.."GC-MS and LC-MS/MS pilot studies on the guanidine (NG)-dimethylation in native, asymmetrically and symmetrically NG-dimethylated arginine-vasopressin peptides and proteins in human red blood cells" ." Journal of Chromatography B (2020): 122024

Erythrocytes
Klatt, Stephan, et al."Optimizing red blood cell protein extraction for biomarker quantitation with mass spectrometry." ." Analytical and Bioanalytical Chemistry (2020): 1-14

Erythrocytes
Kitao, Akihito, et al."Band 3 ectopic expression in colorectal cancer induces an increase in erythrocyte membrane-bound IgG and may cause immune-related anemia." ." International Journal of Hematology (2020): 1-10.

Lysed Blood Cells
Elhadi, Suaad Abd, et al."α-Synuclein in blood cells differentiates Parkinson’s disease from healthy controls." ." Annals of Clinical and Translational Neurology.

Haemolysates
Rosin-Arbesfeld, Rina, and Ronen SIMAN-TOV. "Article of manufacture and methods for increasing survival of red blood cells." ." U.S. Patent Application No. 15/739,857.

Rainbow Trout Fish Nucleated Red Blood Cells (RBCs)
Puente-Marin, Sara, Iván Nombela, Sergio Ciordia, María Carmen Mena, Verónica Chico, Julio Coll, and María del Mar Ortega-Villaizan. " In Silico Functional Networks Identified in Fish Nucleated Red Blood Cells by Means of Transcriptomic and Proteomic Profiling ." Genes 9, no. 4 (2018): 202.

Nombela I, Puente-Marin S, Chico V et al." "Identification of diverse defense mechanisms in trout red blood cells in response to VHSV halted viral replication [version 1; referees: awaiting peer review]." ." F1000Research 2017, 6:1958 (doi: 10.12688/f1000research.12985.1)

Nombela, Ivan, Sara Puente-Marin, Veronica Chico, Alberto J. Villena, Begoña Carracedo, Sergio Ciordia, Maria Carmen Mena et al. " trout red blood cells in response to halted replication of VHS virus [version 2; referees: 3 approved with reservations]."

Rogers, Stephen C., and Allan Doctor. " Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage ." (2018).

Cortese-Krott, Miriam M., et al." "Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease." ." Redox Biology (2017).

Carvalho, Ana Sofia, Manuel S. Rodriguez, and Rune Matthiesen. " Red Blood Cells in Clinical Proteomics ." Serum/Plasma Proteomics: Methods and Protocols (2017): 173-181.

Human Red Blood Cells (RBC)

Nemkov, Travis, Kaiqi Sun, Julie A. Reisz, Anren Song, Tatsuro Yoshida, Andrew Dunham, Matthew J. Wither et al. " Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage ." haematologica 103, no. 2 (2018): 361-372.

Feliciano, Amélia, Fátima Vaz, Cristina Valentim-Coelho, Vukosava M. Torres, Rita Silva, Vesna Prosinecki, Bruno M. Alexandre et al. " Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome ." Data in Brief (2017).

HemoVoid™ On Bead Digestion Application Work On RBC by Irene Granlund, Umeå University

Red Blood Cells, Plasmodium extracts
Machado, Patrícia Isabel Pires. Pyruvate kinase and glucose-6-phosphate dehydrogenase deficiencies and their association with malaria–population genetics and proteomic studies . Diss. Universidade do Porto, 2013.

Walpurgis, Katja, et al. " Effects of gamma irradiation and 15 days of subsequent ex vivo storage on the cytosolic red blood cell proteome analyzed by 2D DIGE and Orbitrap MS ." PROTEOMICS-Clinical Applications (2013).

P. Falciparum Clone 3D7 Cultured In Human Erythrocytes
Lasonder E, Green JL, Camarda G, Talabani H, Holder AA, Langsley G, Alano P. The Plasmodium falciparum schizont phospho-proteome reveals extensive phosphatidylinositol and cAMP-Protein Kinase A signalling . J Proteome Research. 2012;

Red Blood Cell Lysate
Barasa, Benjamin, and Monique Slijper. " Challenges for red blood cell biomarker discovery through proteomics ." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844.5 (2014): 1003-1010.

Lange, Philipp F., Pitter F. Huesgen, Karen Nguyen, and Christopher M. Overall. " Annotating N termini for the Human Proteome Project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome ." Journal of proteome research (2014).

Katja Walpurgis, Maxie Kohler, Andreas Thomas et al. Validated hemoglobin-depletion approach for red blood cell lysate proteome analysis by means of 2D-PAGE and Orbitrap MS .Electrophoresis.2012;

Mizukawa, B., George, A., Pushkaran, S. et al. Cooperating G6PD mutations associated with severe neonatal hyperbilirubinemia and cholestasis .Pediatric Blood Cancer.2011;56: 840-842.

Sudha Neelam, David G Kakhniashvili, Stephan Wilkens et al. Functional 20S proteasomes in mature human red blood cells Experimental Biology and Medicine.2011;236:580-591

HemoVoid™ Blood Card Kit
The HemoVoid™ Blood Card kit substantially reduces hemoglobin interference from dried blood spot protein analytes

Red Blood Cells

Dried blood spots for detection of autologous blood doping with targeted LC-MS/MS
Matt Kuruc1; Swapan Roy1; Johan Jakobsson2; Raik Wagner2; Christer Malm2; 1Biotech Support Group (BSG) LLC, Monmouth Junction, NJ; 2Pro Test Diagnostics AB (PTD), Umeå, Sweden

HemogloBind™ Blood Card Kit
Hemoglobin Depletion and Protein Enrichment From Dried Blood Spots

Red Blood Cells

Dried blood spots for detection of autologous blood doping with targeted LC-MS/MS
Matt Kuruc1; Swapan Roy1; Johan Jakobsson2; Raik Wagner2; Christer Malm2; 1Biotech Support Group (BSG) LLC, Monmouth Junction, NJ; 2Pro Test Diagnostics AB (PTD), Umeå, Sweden

Delipidation

Cleanascite™ References

Conditioned media

Flury, Anna, et al."A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion." Neuron (2024).

Phospholipid analysis

Playford M, Li H, Dey A, Florida E, Teague H, Gordon S, Mehta N,"HDL associated Vitamin D Binding Protein levels are Inversely Associated with Necrotic Plaque Burden in Psoriasis" ,Atherosclerosis Plus, https://doi.org/10.1016/j.athplu.2024.12.002.

Serum Samples

Huneault HE, Lo JS, Bai S, He Z, McPhaul MJ, Bril F, et al."Fasting intact insulin by mass spectrometry is associated with metabolic dysfunction-associated steatotic liver disease in youth."  Hepatol Commun. 2024;8: e0582. https://doi.org/10.1097/ HC9.0000000000000582

Cancer Supernatant Culture Media

Dahal, Ankit, et al. "Platelet-activating factor (PAF) promotes immunosuppressive neutrophil differentiation within tumors."  Proceedings of the National Academy of Sciences 121.35 (2024): e2406748121.

Omental Conditioned Medium (OCM)

Wang, H., Yung, M.M., Xuan, Y. et al. "Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironment."  Exp Hematol Oncol 13, 90 (2024). https://doi.org/10.1186/s40164-024-00558-8

Human saliva samples

Arora, Pearl, et al."Nanopore‐based detection of periodontitis biomarker miR31 in saliva samples."  Electrophoresis (2024).

MRS+CQ broth (De Man, Rogosa, and Sharpe broth with cysteine and glutamine)

Zhu, Meilin, et al."Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment."  Cell (2024).

Toxoplasma gondii

Swapna LS, Stevens GC, Sardinha-Silva A, Hu LZ, Brand V, Fusca DD, et al."ToxoNet: A high confidence map of protein-protein interactions in Toxoplasma gondii."  PLoS Comput Biol 20(6): e1012208. https://doi.org/10.1371/ journal.pcbi.1012208

Conditioned Media (CM)

Zhang, T., Zhao, F., Hu, Y. et al."Environmental monobutyl phthalate exposure promotes liver cancer via reprogrammed cholesterol metabolism and activation of the IRE1α-XBP1s pathway."  Oncogene (2024). https://doi.org/10.1038/s41388-024-03086-1

Flury, Anna, et al."Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegeneration."  bioRxiv (2024): 2024-03.

Adipocyte-conditioned media (ACM)

El-Hattab, Mariam Y., et al. "Native adiponectin plays a role in the adipocyte-mediated conversion of fibroblasts to myofibroblasts."  Journal of the Royal Society interface 20.202 (2023): 20230004.

Ascites Fluid

Testa, Anna, et al. "TARGETING THE αVβ3/NgR2 PATHWAY IN NEUROENDOCRINE PROSTATE CANCER."  Matrix Biology (2023).

Bovine Aorta

Yao, Yimin, et al. "Accurate quantification of lysyl oxidase concentration in human tissue." bioRxiv (2023): 2023-07.

PPACK PFC Nanoparticles

Vargas, Ian, et al. "Simultaneous Inhibition of Thrombosis and Inflammation Is Beneficial in Treating Acute Myocardial Infarction." International journal of molecular sciences 24.8 (2023): 7333.

Bone Marrow Samples

Gudgeon, Nancy, et al. "Uptake of long-chain fatty acids from the bone marrow suppresses CD8+ T-cell metabolism and function in multiple myeloma." Blood Advances (2023).

Activated hepatic stellate cells

Sinha, S., Aizawa, S., Nakano, Y. et al.Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis. Nat Commun 14, 2651 (2023). https://doi.org/10.1038/s41467-023-38406-8

Bile

Qin WH, Liu JT, Wang SP, Yang ZS, Wang KK, Hu B.Antibody array-based proteomic screening of novel biomarkers in malignant biliary stricture. Cancer Biomark. 2022;33(3):359-368. doi: 10.3233/CBM-210095. PMID: 34542063.

Bone Marrow (BM) Plasma

Gudgeon, Bishop, et al."CD8+ T cell metabolism and function are suppressed by long-chain fatty acid uptake from the bone marrow microenvironment in Multiple Myeloma." (2023).

Lacticaseibacillus casei BL23

da Silva Barreira, David, et al. "Membrane vesicles released by Lacticaseibacillus casei BL23 inhibit the biofilm formation of Salmonella Enteritidis." Scientific Reports 13.1 (2023): 1163.

RNA cargo

Castleberry, Mark, et al."High-density lipoproteins mediate small RNA intercellular communication between dendritic cells and macrophages." Journal of Lipid Research(2023): 100328.

Omental Conditioned Medium (OCM)

Chan, David, et al."Polyunsaturated Fatty Acids Promote Protumoral Macrophage Polarization via a RhoA-YAP1 Signaling Pathway in the Ovarian Cancer Microenvironment." Research Square (2022).

Bone Marrow Neutrophil Cells With RPMI Containing 0.5% FBS or with 10% FBS

Pham, Ly, et al."Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation." Communications Biology5.1 (2022): 1-13.

Cell Culture Grade Fetal Bovine Serum (FBS) and BSA

Jiang, Lifeng, et al." Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension ." Frontiers in medicine 9 (2022).

Detect Tuberculosis Virulence Factors In Serum

Zheng, Wenshu, et al. "Nanopore-based disease diagnosis using pathogen-derived tryptic peptides from serum." Nano Today 45 (2022): 101515.

Tumor-conditioned medium

Albakri, Marwah M., et al. "Fatty acids secreted from head and neck cancer induce M2‐like Macrophages." Journal of Leukocyte Biology (2022).

SZ95 medium

Flori, E., Mastrofrancesco, A., Mosca, S., Ottaviani, M., Briganti, S., Cardinali, G., Filoni, A., Cameli, N., Zaccarini, M., Zouboulis, C.C., Picardo, M. ,Sebocytes contribute to melasma onset , ISCIENCE (2022).

Omental Conditioned Medium (OCM)

Yang, X. U. A. N., et al. "" SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells ."" (2021).

Culture media

Di Conza, Giusy, et al. ""Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity." " Nature immunology(2021): 1-13.

A precipitate of lipids

Greenfield, Edward A. ""Inducing, collecting, and storing ascites."" Cold Spring Harbor Protocols2021.10 (2021): pdb-prot103309.

Omental Conditioned Medium (OCM)

Wang, Xueyu, et al. ""Epigenetic Silencing of miR-33b Promotes Peritoneal Metastases of Ovarian Cancer by Modulating the TAK1/FASN/CPT1A/NF-κB Axis." " Cancers13.19 (2021): 4795.

Lipid-depleted serum

Chen, Hsin-Yi, et al. "Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma." bioRxiv(2021).

Birch pollen extracts

Pointner, Lisa, et al. "Birch pollen induces Toll-like receptor 4-dependent dendritic cell activation favoring T cell responses."Frontiers in Allergy(2021): 42.

Fetal Bovine Serum

Guyon, Léna, Miller-Rhodes, Patrick, and Harris A. Gelbard. "The Cell Culture Environment Regulates the Transcription Factor MafB in BV-2 Microglia." Matters 7.1 (2021): e202010000001.

Predialysis PPACK-liposomes

Guyon, Léna, Anne-Claire Groo, and Aurélie Malzert-Fréon. "Relevant Physicochemical Methods to Functionalize, Purify, and Characterize Surface-Decorated Lipid-Based Nanocarriers." Molecular Pharmaceutics (2020).

Egg Extract

Stahl, Elia, et al. "Phosphatidylcholines from Pieris brassicae eggs activate an immune response in Arabidopsis." eLife 9 (2020): e60293.

Tissue culture supernatants

Greenfield, Edward A. "Collecting and Storing Hybridoma Tissue Culture Supernatants." Cold Spring Harbor Protocols 2020.10 (2020): pdb-prot103317.

OCM (Omental conditioned medium) culture

Chan, David W., et al "MAP30 protein from Momordica charantia is therapeutic and has synergic activity with cisplatin against ovarian cancer in vivo by altering metabolism and inducing ferroptosis." Pharmacological Research (2020): 105157

Cancer cell-conditioned medium

Wang, Haiping, et al. "CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors." Nature Immunology (2020): 1-11

Omental conditioned medium (OCM)

Chen, Rain R., et al. "Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells." Communications Biology 2 (2019).

Human serum, mouse serum or DMEM

Lee, Hong-Jai, et al. "Regulatory effect of humoral milieu on the viral DNA and surface antigen expression of hepatitis B virus (HBV) in vitro. Molecular & Cellular Toxicology. 15.2 (2019): 123-128..

Body fluids

Farina, Annarita. "Pre-fractionation of Noncirculating Biological Fluids to Improve Discovery of Clinically Relevant Protein Biomarkers." Proteomics for Biomarker Discovery. Humana Press, New York, NY, 2019. 23-37.

Astrocyte conditioned media

Sprenkle, Neil T., et al. "Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system." Journal of Neurochemistry.

Whole Mouse Serum

Dean, E. Danielle, et al. "Interrupted glucagon signaling reveals hepatic α cell axis and role for L-glutamine in α cell proliferation." Cell metabolism 25.6 (2017): 1362-1373.

Plasma

Swertfeger, Debi K., et al Feasibility of a Plasma Bioassay to Assess Oxidative Protection of Low Density Lipoproteins by High Density Lipoproteins " Journal of Clinical Lipidology (2018).

Estrous sheep serum

Barrera, N., dos Santos Neto, P. C., Cuadro, F., Bosolasco, D., Mulet, A. P., Crispo, M., & Menchaca, A. (2018). Impact of delipidated estrous sheep serum supplementation on in vitro maturation, cryotolerance and endoplasmic reticulum stress gene expression of sheep oocytes PloS one, 13(6), e0198742.

Extracellular vesicles (EVs) from bone marrow (BM)-derived mesenchymal stromal cells (BM-MSC)

Nguyen, Doan C., Holly C. Lewis, Chester Joyner, Vivien Warren, Haopeng Xiao, Haydn T. Kissick, Ronghu Wu, Jacques Galipeau, and F. Eun-Hyung Lee. "Extracellular vesicles from bone marrow-derived mesenchymal stromal cells support ex vivo survival of human antibody secreting cells." Journal of extracellular vesicles 7, no. 1 (2018): 1463778.

Pancreatic Rough Endoplasmic Reticulum (RER) Fractions

Waldron, Richard T., Hsin-Yuan Su, Honit Piplani, Joseph Capri, Julian P. Whitelegge, Kym F. Faull, Sugunadevi Sakkiah et al. " Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model ." Cellular and Molecular Gastroenterology and Hepatology 5, no. 4 (2018): 479-497

Human SZ95 sebocytes

Lovászi, M., et al. " Sebum lipids influence macrophage polarization and activation ." British Journal of Dermatology (2017). doi: 10.1111/bjd.15754

Ascites Fluid

Chan, DW, Mak, SL, Ngan, HYS. The significance of lipid metabolism in peritoneal metastases of ovarian cancer. The 2016 Cold Spring Harbour Asia Conference on Cancer and Metabolism, Suzhou, China, 19-23 September 2016. http://hub.hku.hk/handle/10722/235385

Serum

Shiffman, Dov, et al. "Methods for quantitation of insulin and c-peptide." U.S. Patent Application No. 15/942,188

Taylor, Steven W., et al. " A high-throughput mass spectrometry assay to simultaneously measure intact insulin and C-peptide ." Clinica Chimica Acta (2016).

Serum or Blood

Berggren, Per Olof, and Shao-Nian Yang. " Methods for treating and/or limiting development of diabetes ." U.S. Patent Application No. 14/995,341.

Bile

Vesterhus, Mette, et al." Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. " Journal of hepatology 66.6 (2017): 1214-1222.

Hauser-Davis, Rachel Ann. " Fish Bile Clean-up for Subsequent Zymography and Mass Spectrometry Proteomic Analyses. " (2018).

Laohaviroj, Marut, et al. " A comparative proteomic analysis of bile for biomarkers of cholangiocarcinoma ." Tumor Biology 39.6 (2017): 1010428317705764.

Vesterhus, Mette, Anders Holm, Johannes Roksund Hov, Ståle Nygård, Erik Schrumpf, Espen Melum, Liv Wenche Thorbjørnsen et al. " "Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis." Journal of Hepatology (2017). ."Journal of Hepatology (2017).

Megger, Dominik A., et al. " One Sample, One Shot-Evaluation of sample preparation protocols for the mass spectrometric proteome analysis of human bile fluid without extensive fractionation ." Journal of Proteomics (2016).

Lukic, Natalija, et al. " An integrated approach for comparative proteomic analysis of human bile reveals overexpressed cancer-associated proteins in malignant biliary stenosis ." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844.5 (2014): 1026-1033.

Danese, Elisa, et al. " Assessment of bile and serum mucin5AC in cholangiocarcinoma: Diagnostic performance and biologic significance ."Surgery (2014).

Farina, Annarita, et al. " Bile carcinoembryonic cell adhesion molecule 6 (CEAM6) as a biomarker of malignant biliary stenoses. " Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics (2013).

Boschetti, Egisto, and Pier Giorgio Righetti. Low-Abundance Proteome Discovery: State of the Art and Protocols . Newnes, 2013.

Wang W, Ai KX, Yuan Z, Huang XY, Zhang HZ. Different Expression of S100A8 in Malignant and Benign Gallbladder Diseases .Digestive diseases and sciences. 2012.

Hauser-Davis RA, Lima AA, Ziolli RL, Campos RC. First-time report of metalloproteinases in fish bile and their potential as bioindicators regarding environmental contamination .Aquatic Toxicology.2012;110-111:99-106

Farina A, Dumonceau JM, Frossard JL. Proteomic Analysis of Human Bile from Malignant Biliary Stenosis Induced by Pancreatic Cancer Journal of Proteome Research.2009; 8(1):159-69

Guerrier L, Claverol S, Finzi L et al. Contribution of solid-phase hexapeptide ligand libraries to the repertoire of human bile proteins. Journal of Chromatography.2007;1176(1-2):192-205

Chen Bo, Zheng Jian-wei, Wang Jian-ming, et al. Establishment and preliminary analysis of a 2-D human biliary map . Chinese Journal of Hepatobiliary Surgery.2007

Chen B, Dong JQ, Chen YJ et al Two-dimensional electrophoresis for comparative proteomic analysis of human bile . Hepatobiliary & pancreatic diseases international.2007 Aug;6(4):402-6

Guerrier L, Claverol S, Finzi L et al Contribution of solid-phase hexapeptide ligand libraries to the repertoire of human bile proteins. Journal of Chromatography A.2007;1176(1-2):192-205

Kristiansen TZ, Bunkenborg J, Gronborg M et al A Proteomic Analysis of Human Bile Molecular and Cellular Proteomics.2004;3:715-728

Biological Matrices

Graeme T Clark, Paul J Russell, and Steven Westwood. Modification without impact: a case study in clinical assay failure due to lipemia . Bioanalysis; 2012: 4,(12):1421-1428

Egg Yolk

Ben Wade, Michelle Cummins, Anthony Keyburn and Tamsyn M. Crowley. Isolation and detection of microRNA from the egg of chickens . BMC Research Notes 2016 9:283.

Organ Homogenates

Myerson, J., He, L., Lanza, G., Tollefsen, D. and Wickline, S. Thrombin-inhibiting perfluorocarbon nanoparticles provide a novel strategy for the treatment and magnetic resonance imaging of acute thrombosis . Journal of Thrombosis and Haemostasis.2011;9:1292-1300

Thakuria D, Schmidt O, Liliensiek AK. Field preservation and DNA extraction methods for intestinal microbial diversity analysis in earthworms . Journal of Microbiological Methods.2009;76(3):226-33

Cheng AM, Moore EE, Masuno T et al Normal Mesenteric Lymph Blunts the Pulmonary Inflammatory Response to Endotoxin. Journal of Surgical Research.2006;136(S2):166-171

McNally T, Mackie IJ, Machin SJ et al. Increased levels of beta 2 glycoprotein I antigen and beta 2 glycoprotein I binding antibodies are associated with a history of thromboembolic complications in patients with SLE and primary antiphospholipid syndrome British journal of rheumatology.1995 Nov;34(11):1031-6

Red Blood Cells

Antunes RF; Brandao C; Maia M; Arosa FA. Red blood cells release factors with growth and survival bioactivities for normal and leukemic T cells . Immunology and Cell Biology.2011;89(1):111-21

Tracheal Swab Samples

Li D, Wang J, Wang R, Li Y. A nanobeads amplified QCM immunosensor for the detection of avian influenza virus H5N1 , Biosensors and Bioelectronics.2011;26(S10):4146-4154

Fu LM, Shinnick TM. Genome-wide exploration of the drug action of capreomycin on Mycobacterium tuberculosis using Affymetrix oligonucleotide GeneChips Journal of Infection.2007;54(S3):277-284

Fu LM, Shinnick TM. Genome-wide analysis of intergenic regions of mycobacterium tuberculosis H37Rv using affymetrix genechips . EURASIP journal on bioinformatics & systems biology.2007:23054

Tissue and Cell Culture

United States Patent Application 20170348398 entitled: " COMPOSITIONS AND METHODS FOR DECREASING BLOOD GLUCAGON LEVELS ”

Ahmed, Syed Mukhtar, and Ian G. Macara The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. . Nature Communications.8 (2017): 14867. doi:10.1038/ncomms14867

Alhamdani MS, Schroder C, Hoheisel JD. Analysis conditions for proteomic profiling of mammalian tissue and cell extracts with antibody microarrays . Proteomics.2010;10(17):3203-7

Czambel RK, Kharlamov A, Jones SC. Variations of brain endothelial nitric oxide synthase concentration in rat and mouse cortex .Nitric Oxide.2010;22(S1): 51-57

Plasma/Serum

McIntyre, John A., et al. " Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer's disease ." Autoimmunity0 (2015): 1-8.

Knight, Jason S., Wei Luo, Alexander A. O'Dell, Srilakshmi Yalavarthi, Wenpu Zhao, Venkataraman Subramanian, Chiao Guo et al. " Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis ." Circulation research (2014): CIRCRESAHA-113.

Palekar, Rohun U., et al. " Thrombin-Targeted Liposomes Establish A Sustained Localized Anticlotting Barrier Against Acute Thrombosis. " Molecular pharmaceutics (2013).

Lijowski M, Caruthers S, Hu G. High-Resolution SPECT-CT/MR Molecular Imaging of Angiogenesis in the Vx2 Model . Investigative Radiology.2009;44(1): 15–22

Turner JD, Langley RS, Johnston KL. Wolbachia Lipoprotein Stimulates Innate and Adaptive Immunity through Toll-like Receptors 2 and 6 to Induce Disease Manifestations of Filariasis The Journal of Biological Chemistry.2009;284:22364-22378

Torrelles JB, DesJardin LE, MacNeil J. et al Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death Glycobiology.2009;19(7):743-755

Cho N, Chueh PJ, Kim C et al Monoclonal antibody to a cancer-specific and drug-responsive hydroquinone (NADH) oxidase from the sera of cancer patients. Cancer Immunology, Immunotherapy. 2002;51(3):121-9

Shapiro S, Beenhouwer DO, Feldmesser M et al. Immunoglobulin G Monoclonal Antibodies to Cryptococcus neoformans Protect Mice Deficient in Complement Component C3 Infect. Infection and immunity.2002;70(5):2598-604

Castro AR, Morrill We, Pope V. Lipid Removal from Human Serum Samples Clinical and diagnostic laboratory immunology.2000;7(2):197-199

Nussbaum G, Cleare W, Casadevall A et al Epitope Location in the Cryptococcus neoformans Capsule Is a Determinant of Antibody Efficacy The Journal of experimental medicine.1997;185:685-694

Nanoparticles

Human & Plasma Cell Lines
Pan, Dipanjan, et al. "A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy ." Nanomedicine 10.2 (2015): 241-251.

Plasma-Enzyme-Nanoparticle Mixture
Pan, Dipanjan, et al. " Anti-Angiogenesis Therapy in the Vx2 Rabbit Cancer Model with a Lipase-cleavable Sn 2 Taxane Phospholipid Prodrug using αvβ3-Targeted Theranostic Nanoparticles ." Theranostics 2014; 4(6):565-578

Microarray

Srinivasan, Harish." Antibody microarray as a proteomic tool for effective diagnosis and prediction of prognosis in cancer. "(2014).

Saliva

Lucy E. DesJardin Isolation of M. tuberculosis RNA from Sputum Methods in Molecular Medicine.2001;48:133-139

Beenhouwer DO, Shapiro S, Feldmesser M et al. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans Infection and immunity.2001;69: 6445-6455

Desjardin LE, Perkins MD, Wolski K et al. Measurement of Sputum Mycobacterium tuberculosis Messenger RNA as a Surrogate for Response to Chemotherapy American journal of respiratory and critical care medicine.1999;160(1):203-10

Template Preparation Production Sequencing Protocols. Stanford Genome Technology Center

Patents

Iwakura Yoichiro, Kakuta Shigeru, Suzuki, Shunsuke - United States Patent Application 20130011413. Method and Pharmaceutical Composition for Treatment of Intestinal Disease

Mcintyre, John A. United States Patent: 20120107841. Serum Diagnostic Method, Biomarker and Kit for Early Detection and Staging of Alzheimer's Disease

Morre, James D et al. United States Patent: 20030170757. Monoclonal antibodies specific for neoplasia-specific NADH: disulfide reductase

DJ Morre, NM McCarty, D Morre et al United States Patent: 7053188. Monoclonal antibodies specific for neoplasia-specific NADH: disulfide reductase

David C. Jones. United States Patent: 7999084. Devices and methods for reducing matrix effects

J Krupey - United States Patent: 5885921 Hydrophobic silica adsorbents for lipids

Vaccine Research (Cholesterol Removal From Human Serum)

Kamtchoua, Thierry, Monica Bologa, Robert Hopfer, David Neveu, Branda Hu, Xiaohua Sheng, Nicolas Corde, Catherine Pouzet, Gloria Zimmerman, and Sanjay Gurunathan. Safety and immunogenicity of the pneumococcal pneumolysin derivative PlyD1 in a single-antigen protein vaccine candidate in adults. Vaccine (2012).

Yeast assays

Lifang, et al. Balanced globin protein expression and heme biosynthesis improve production of human hemoglobin in Saccharomyces cerevisiae . Metabolic Engineering (2013).