Technical Resources References Peer-reviewed publications, application reports, and patents citing Biotech Support Group products, organized by application category. Jump to a category, then scan by product and sample type.
14 categories
Albumin Depletion Hemoglobin Depletion Delipidation Protein Removal Protein Enrichment Sample Prep Mass Spectrometry Virus Enrichment Detergent Removal Functional & Chemical Proteomics Genomics Featured Applications Application Reports Liquid Biopsy Patents (Third Party) AlbuSorb™ Albumin Depletion Kit Serum/Plasma Ching, J.J., Shuib, A.S., Majid, N.A., Taufek, N.M., Ismail, M.N. & Abdullah, N. 2025. Pleurotus pulmonarius stalk waste extract supplementation modulates serum proteins level in red hybrid tilapia Oreochromis sp. upon pamps challenge. Malaysian Applied Biology, 54(3): 76-88. Intestinal Organoid Supernatants Jordan, Christine KI, et al. "Symbiotic Firmicutes establish mutualism with the host via innate tolerance and resistance to control systemic immunity. " Cell Host & Microbe (2023). Intestinal Organoid Supernatants Matsuzawa-Ishimoto, Yu, et al. "The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death. " Nature (2022): 1-8. Human serum High-throughput, Automated INTip™ SPE Combined with AlbuSorb™ Products for Efficient Albumin and Albumin/IgG Depletion . Matthew Fitts; William E. Kemnitzer; Paul Meeh (DPX Technologies, Columbia, SC); Matt Kuruc; Swapan Roy; Sowmya Avadhani (Biotech Support Group LLC, Monmouth Junction, NJ).Clarified serum A Preliminary Investigation Using Targeted LC-MS Proteomic Methods Demonstrates Unique Serum Profiles of Hospitalized SARS-CoV-2 Patients . Douglas D Fraser; Haiyan Zheng; Swapan Roy; Matt Kuruc; Amenah Soherwardy; Devjit Roy; Sowmya Avadhani.Whole blood, serum and plasma samples DPX Technologies and Biotech Support Group Announce In-Market Partnership for High Throughput Proteomic Sample Prep .Serum Exosomes Valladolid-Acebes, Ismael, et al. "Lowering apolipoprotein CIII protects against high-fat diet–induced metabolic derangements. " Science Advances 7.11 (2021): eabc2931. Serum Exosomes Chettimada, Sukrutha, et al. "Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy. " Scientific Reports 8.1 (2018): 7227. Cerebrospinal Fluid Gwenael Pottiez, Pawel Ciborowski. Proteomic Profiling of Cerebrospinal Fluid Expression Profiling In Neuroscience. Neuromethods. 2012;64:245-270. Synovial fluid Happonen KE, Fürst CM, Saxne T et al. PRELP protein inhibits the formation of the complement membrane attack complex. Journal of Biological Chemistry. 2012;287(11):8092-100. Serum Vialaret, Jerome et al. (2018). "Albumin depletion of human serum to improve quantitative clinical proteomics. " Current Topics in Peptide & Protein Research 19. 53-62. Roy, Swapan, and Matthew Kuruc. "Methods to Monitor the Functional Subproteomes of SERPIN Protease Inhibitors. " Functional Proteomics. Humana Press, New York, NY, 2019. 41-54. Berggren, Per-olof, and Lisa Juntti-berggren. "Methods for treating and/or limiting development of diabetes. " U.S. Patent No. 20,170,037,118. 9 Feb. 2017. Swapan Roy, Matthew Kuruc. The Functional Subproteomes of Serpin Protease Inhibitors are Now Open for LC-MS Biomarker Discovery. MOJ Proteomics Bioinform 2016, 3(6): 00106. Holmberg R, Refai E, Höög A. Lowering apolipoprotein CIII delays onset of type 1 diabetes. Proceedings of the National Academy of Sciences. 2011;108(26):10685-9. Tang MX, Ogawa K, Asamoto M. Effects of Nobiletin on PhIP-Induced Prostate and Colon Carcinogenesis in F344 Rats. Nutrition and Cancer. 2011;63(2):227-33. Holmberg, Rebecka. Apolipoprotein CIII and Ljungan virus in diabetes. 2010. Doctoral Thesis. Lu Q, Zheng X, McIntosh T. Development of different analysis platforms with LC-MS for pharmacokinetic studies of protein drugs. Analytical Chemistry. 2009;81(21):8715-23. Urine Zubiri, Irene, et al. "Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis. " Journal of proteomics 96 (2014): 92-102. Patent Berggren, Per Olaf, Yang, Shao-Nian. 2012. Methods For Treating And/Or Limiting Development Of Diabetes. U.S. Patent 20120328630, filed June 25, 2012, issued December 27, 2012. AlbuTrial™ Kit – AlbuVoid™ and AlbuSorb™ Cerebrospinal Fluid Gwenael Pottiez, Pawel Ciborowski. Proteomic Profiling of Cerebrospinal Fluid Expression Profiling In Neuroscience. Neuromethods. 2012;64:245-270. Synovial fluid Happonen KE, Fürst CM, Saxne T et al. PRELP protein inhibits the formation of the complement membrane attack complex. Journal of Biological Chemistry. 2012;287(11):8092-100. Serum Holmberg R, Refai E, Höög A. Lowering apolipoprotein CIII delays onset of type 1 diabetes. Proceedings of the National Academy of Sciences. 2011;108(26):10685-9. Tang MX, Ogawa K, Asamoto M. Effects of Nobiletin on PhIP-Induced Prostate and Colon Carcinogenesis in F344 Rats. Nutrition and Cancer. 2011;63(2):227-33. Holmberg, Rebecka. Apolipoprotein CIII and Ljungan virus in diabetes. 2010. Doctoral Thesis. Lu Q, Zheng X, McIntosh T. Development of different analysis platforms with LC-MS for pharmacokinetic studies of protein drugs. Analytical Chemistry. 2009;81(21):8715-23. AlbuVoid™ References Serum/Plasma Paulsen et al., "Development of human induced pluripotent stem cell-derived ovarian support cells as a clinical-grade product for in vitro fertilization, " Cell Stem Cell (2025). Serum/Plasma Golden, Lesley R., et al. "APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition. " Nature Neuroscience (2025): 1-15. Conditioned media Paulsen, Bruna, et al. "Reproducible differentiation of pure ovarian support cells from clinical-grade hiPSCs as a novel infertility treatment. " bioRxiv (2024): 2024-04. Tumor-stroma ratio Polack, M., et al. "Results from the UNITED study: a multicenter study validating the prognostic effect of the tumor–stroma ratio in colon cancer. " ESMO open 9.4 (2024): 102988. Plasma Sae-Lee, Wisath, et al. "The protein organization of a red blood cell. " Cell Reports 40.3 (2022): 111103. Culture Supernatants / Cell Secretome Proteome Analysis Jenull, Sabrina, et al. "The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence. " Cell Reports 36.3 (2021): 109406. Osteogenic and Fibrogenic Blood Composites Jing, Lun, et al. "Proteomic analysis identified LBP and CD14 as key proteins in blood/biphasic calcium phosphate microparticle interactions. " Acta Biomaterialia (2021). Blood Targeted LC-MS Proteomic Methods to Monitor and Quantify Stromal Conditioning in Cancer from Blood. Matt Kuruc; Swapan Roy; Wilma Mesker; Rob Tollenaar.Blood Kuruc M, Zheng H, Sowerhardy A, Avadhani S, Roy D, et al. (2020) "New Strategies to Categorize Blood for Proteomic Biomarker Discovery. " Proteomics Bioinformatics , 2(2): 90-107. Biotech Support Group to exhibit at the 67th ASMS Conference on Mass Spectrometry & Allied Topics. Application Report Stroma Liquid Biopsy – Pan-Cancer Dysregulation of the Serum Proteome. Haiyan Zheng; Swapan Roy; Devjit Roy; Amenah Soherwardy; Seema Rathman; Matthew Kuruc.Serum Roy, Swapan, and Matthew Kuruc. "Methods to Monitor the Functional Subproteomes of SERPIN Protease Inhibitors. " Functional Proteomics. Humana Press, 2019. 41-54. Poillet-Perez, Laura, et al. "Autophagy maintains tumour growth through circulating arginine. " Nature (2018): 1. David L. Wang, Chuanguang Xiao, Guofeng Fu, Xing Wang and Liang Li. "Identification of potential serum biomarkers for breast cancer using a functional proteomics technology. " Biomarker Research (2017) 5:11. Sun, Zhenyu, et al. "Identification of functional metabolic biomarkers from lung cancer patient serum using PEP technology. " Biomarker Research 4, no. 1 (2016): 1. Xing Wang, Michael Davies, Swapan Roy and Matthew Kuruc. Bead Based Proteome Enrichment Enhances Features of the Protein Elution Plate (PEP) for Functional Proteomic Profiling. Proteomes 2015, 3(4), 454-466. Grubbs, J. K., et al. "Investigation of the efficacy of albumin removal procedures on porcine serum proteome profile. " (2015). Kuruc Matt. Application Report – AlbuVoid™ & On-Bead Digestion – Tackling the challenges of serum proteomics (LC-MS). Patents Narain, Niven Rajin, et al. "Interrogatory cell-based assays for identifying drug-induced toxicity markers. " U.S. Patent Application No. 16/180,446. Plasma Espes, Daniel, Joey Lau, and Per-Ola Carlsson. "Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes. " Diabetologia (2013): 1-4. AlbuSorb™ PLUS Serum/Plasma Sovakova, Magdalena, et al. "Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood. " European Journal of Pharmacology (2026): 178725. Serum Fraser DD, Roy S, Kuruc M, et al. (2025) "Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity. " Exp. Biol. Med. 250:10308. Plasma samples Grantz, Jillian M., et al. "The platelet and plasma proteome and targeted lipidome in postpartum dairy cows with elevated systemic inflammation. " Scientific Reports 14.1 (2024): 31240. Whole blood, serum and plasma samples DPX Technologies and Biotech Support Group Announce In-Market Partnership for High Throughput Proteomic Sample Prep. Serum/Plasma Samples Biotech Support Group & Lawson Health Research Institute Enter Collaborative Research Agreement to Monitor Protease Inhibitor Function During Covid-19 Infections. Serum Thangavelu, Bharani, et al. "Dataset of Rat and Human Serum Proteomes Derived from Differential Depletion Strategies prior to Mass Spectrometry. " Data in Brief (2020): 105657. Application Report AlbuVoid™ PLUS & AlbuSorb™ PLUS – Evaluating Different Windows of Observation Solves The Many Challenges of Serum Proteomics. AlbuVoid™ PLUS – Albumin and IgG Depletion From Serum/Plasma for Proteomics References AlbuVoid™ PLUS & AlbuSorb™ PLUS – Evaluating Different Windows of Observation Solves The Many Challenges of Serum Proteomics. Zheng H, Soherwardy A, Roy S, Kuruc M, Avadhani S. AlbuVoid™ Enrichment & Antibody Depletion – Tackling the Challenges of Serum Proteomics Part II. Poster, 26th International Molecular Med TRI-CON, March 10-15, 2019, San Francisco, CA. Mihara, Keisuke, et al. "Identification of Specific Protein Markers of Rheumatoid Arthritis in Synovial Fluid and Serum. " Journal of Hard Tissue Biology 27.1 (2018): 55-58. Zheng, H., et al. "AlbuVoid™ coupled to on-bead digestion – tackling the challenges of serum proteomics. " J Proteom Bioinformatics 8.9 (2015): 225. 02 Hemoglobin Depletion Top ↑ NuGel-HemogloBind™ – Hemoglobin Capture Reagent From Blood and Hemolyzed Serum Tissue Lysates Zakari, Abubakar, et al. "Extreme Temperature Exposure Induces Lung-Gut Dysbiosis in Healthy Mice. " Current Research in Microbial Sciences (2026): 100564. Red Cell Lysates Wang, Y., Wu, X., Li, X., et al. "Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes. " iScience (2026). Tumor Interstitial Fluid Zhang, X., Li, S., Malik, I. et al. "Reprogramming tumour-associated macrophages to outcompete cancer cells. " Nature (2023). Whole blood, serum and plasma samples DPX Technologies and Biotech Support Group Announce In-Market Partnership for High Throughput Proteomic Sample Prep. Whole blood Leitner, Dominique F., et al. "Metabolomic, Proteomic, and Transcriptomic Changes in Adults with Epilepsy on Modified Atkins Diet. " Epilepsia (2023). HemogloBind™ – Hemoglobin Depletion From Hemolyzed Serum/Plasma Tissue Lysates Zakari, Abubakar, et al. "Extreme Temperature Exposure Induces Lung-Gut Dysbiosis in Healthy Mice. " Current Research in Microbial Sciences (2026): 100564. Red Cell Lysates Go, Ka Diam, et al. "Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome. " Structure (2025). Species-Agnostic / Tissue Lysates, LC-MS Proteomics Liu, Yi-Hsuan, et al. "ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota. " Molecular Medicine 31 (2025): 204. Red Blood Cells Chen, Yaozhen, et al. "Red blood cells undergo lytic programmed cell death involving NLRP3. " Cell (2025). Fresh frozen human EDTA-whole Blood de Boni, Laura, et al. "Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients. " EMBO Molecular Medicine (2024): 1-18. Pooled Blood Samples Igoh, Akihisa, Masanobu Miura, and Satoru Miyaishi. "Animal Species and Blood Identification with Peptide Mass Fingerprinting. " Analytical Chemistry (2024). Abdominal Aneurysm Samples Jara, Zaira Palomino, et al. "Distinct Mechanisms of β-Arrestin–Biased Agonist and Blocker of AT1R in Preventing Aortic Aneurysm and Associated Mortality. " Hypertension 80.2 (2023): 385-402. Hemolysate Dasauni, Pushpanjali, et al. "Optimization and Identification of Single Mutation in Hemoglobin Variants… " Molecules 27.19 (2022): 6357. Application Reports "Hemoglobin Removal – The Gold Standard Products ", April 28, 2020. "Categorization of Blood Based Biomarkers – Unleashing the Power of Proteomics… ", April 17, 2020. HemoVoid™ References Red Blood Cells (RBCs) / Other Applications Mitra, Nibedita, et al. "Multi-omics analysis of red blood cells reveals thalassemia severity beyond globin gene mutations. " Blood Advances (2026). Dried Blood Card/Spot Proteomics Hannah Ging, Elin Davies, Claire E. Eyers, Louise Oni, Andrew Chetwynd. "Haemoglobin Interference in Dried Blood Spot Proteomics for Chronic Kidney Disease ", Poster 2025 World Proteome Congress, Toronto. Red Blood Cells (RBCs) / Parkinson’s Disease / α-Synuclein Parra M.A., Snyder M.P. "Parkinson’s Disease biomarker discovery via LC-MS/MS characterization and quantification of alpha synuclein PTMs in erythrocytes ", Poster 2025 ASMS Conference, Baltimore MD. Red Blood Cells (RBCs) / COPD Xi-Long Wang, et al. (2025) "Proteome Profiling of Red Blood Cells from Patients with COPD… " International Journal of Chronic Obstructive Pulmonary Disease, 3279-3294. Red Blood Cell (RBC) lysates Lan, Qin, and Zhao-bing Gu. "Data-independent acquisition-based proteome profiling of red blood cells from dairy buffaloes… " Veterinary and Animal Science (2025): 100437. Blood Pawliński, Łukasz, et al. "Proteomic biomarkers in Gaucher disease. " Journal of clinical pathology 74.1 (2021): 25-29. Cleanascite™ References Cell Response Suarez-Carmona, Meggy, et al. "Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer. " Signal Transduction and Targeted Therapy 11.1 (2026): 78. Cell Response Toraason, Erik, et al. "Caenorhabditis elegans avoids Todstoff, a novel nociceptive necrotaxis cue. " bioRxiv (2026): 2026-02. Plasma/Serum Post-Stroke Immune Suppression is Mediated by Bioactive Lipids. An abstract describing the use of Cleanascite™ to compare stroke plasma in ex vivo models of immune suppression.Tissue Proteomics Guldner, Ian H., et al. "Ageing promotes microglial accumulation of slow-degrading synaptic proteins. " Nature (2026): 1-12. Tumor microenvironment (TME) Dyer A., Dudley R., Ahuja S. et al. "Characterisation of human in vitro tumour-associated macrophage models to define translational relevance. " Sci Rep (2025). Plasma/Serum Zhao, Yuan, et al. "A Label-Free Nanopore Biosensor for Rapid and Highly Sensitive Detection of Actinomycin in Human Serum. " ACS Measurement Science Au (2025). Tumor microenvironment (TME) Chu, Tianhao, et al. "Metabolism archetype cancer cells induce protumor TREM2+ macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma. " Nature Communications 16.1 (2025): 6770. Conditioned media Flury, Anna, et al. "A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion. " Neuron (2024). Serum Samples Huneault HE, Lo JS, Bai S, et al. "Fasting intact insulin by mass spectrometry is associated with metabolic dysfunction-associated steatotic liver disease in youth. " Hepatol Commun. 2024;8: e0582. Bile Qin WH, Liu JT, Wang SP, et al. "Antibody array-based proteomic screening of novel biomarkers in malignant biliary stricture. " Cancer Biomark. 2022;33(3):359-368. For Cleanascite™ (Application detail) Megger, Dominik A., et al. "One Sample, One Shot – Evaluation of sample preparation protocols for the mass spectrometric proteome analysis of human bile fluid without extensive fractionation. " Journal of Proteomics (2016). NuGel™ BindPro™ – Protein Removal Lipoproteins Turner, Joseph D., et al. "Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis. " Journal of Biological Chemistry 284, no. 33 (2009): 22364-22378. Patent Bhogal, John, et al. "Methods of Collecting and Analyzing Samples. " U.S. Patent 20,120,296,189, issued November 22, 2012. Review ProCipitate™, Superior Substitute to Phenol/Chloroform for DNA Isolation & Protein Extraction. by Matt Kuruc, February 23, 2015.Patents U.S. Patent Numbers 5,294,681, 5,453,493 and other patents pending. U.S. Patent Number 5,538,870, Method for Preparing Nucleic Acids For Analysis And Kits Useful Therefore. Enteric Viruses Richards, Gary P., and Gail E. Greening. "Detection of enteric viruses in shellfish. " Molluscan Shellfish Safety . Springer Netherlands, 2014. 177-183. 05 Protein Enrichment Top ↑ NRicher™ bead-chemistry enrichment references. Preserve existing citation list here.
06 Sample Prep Mass Spectrometry Top ↑ Additional Sample Prep Mass Spectrometry entries (For Cleanascite™ and related application narratives) continue below the fetch limit – preserve existing entries here.
Virus enrichment / Nanotrap® and related capture references. Preserve existing citation list here.
Detergent removal references. Preserve existing citation list here.
09 Functional & Chemical Proteomics Top ↑ Functional & chemical proteomics references. Preserve existing citation list here.
Genomics / nucleic-acid application references. Preserve existing citation list here.
11 Featured Applications Top ↑ Featured application spotlights. Preserve existing content here.
12 Application Reports Top ↑ Downloadable application reports and posters. Preserve existing list here.
Stroma Liquid Biopsy and related references. Preserve existing list here.
14 Patents (Third Party) Top ↑ Third-party patents citing BSG products. Preserve existing list here.
