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Lipid Removal & Clarification
for the Most Challenging Applications

When protein recovery and cell response matter most, Cleanascite™ is the go-to product for lipid removal and clarification.

That's why it has been cited in over 70 references, more than any other product in these most demanding applications.

Unlike other solid-phases, Cleanascite™ does not have significant protein binding making its selectivity profile for lipids unique in the bio-research products industry. As a result, it is ideal to clear lipid associated matrix effects from human sera, bile, ascites, and other high lipid content sample types.

Benefits of Cleanascite™

Cost Effective & Efficient

Effectively replaced chlorinated/fluorinated hydrocarbons (eg. freon)


Proven workflows for antibodies, proteins, nucleic acids, proteoglycans, serum analytes, and cell response

Species Agnostic

Not derived from immuno-affinity
A high binding capacity for lipids with minimal cross-reactivity with proteins and nucleic acids

Serves Diverse Applications

References for clarifying ascites, serum, cell & tissue culture, bile and organ homogenates

Egg Yolk Clarification
Before and After Cleanascite
Suitable alternative to StatSpin LipoClear

A Look into Lipid Removal Suspension Reagent, Cleanascite™


Lipid Removal Reagent and Clarification


Our Product for Lipemic Serum/Plasma Clarification, Cleanascite™ LX

Cleanascite™ LX

Lipemic Serum / Plasma Clarification

Cleanascite LX

Key References:

Plasma/Serum Protein Biomarkers

The authors aimed at simultaneously measuring intact endogenous-insulin and derived C-peptide, to help predict development of diabetes mellitus, as well as in differential diagnosis in cases of hypoglycemia. Cleanascite™ is shown both to improve LC-MS measurements, and validated in accordance with CLIA '88 guidelines. { doi: 10.1016/j.cca.2016.01.019 }

Vaccine Development

To evaluate immunogenic response to a vaccine candidate, it is necessary to measure the antibodies from sera; a sample with a diverse lipid profile. In this citation, Cleanascite™ was used in a toxin neutralizing assay to evaluate the influence of cholesterol dependency, on a candidate protein pneumococcal vaccine. { doi: 10.1016/j.vaccine.2012.11.005 }

Bile Proteomics

The authors report methods to overcome the biological variability of analyzing a high number of bile samples. They concluded that delipidation yielded a considerable number of complementary protein identifications and that Cleanascite™ treatment was indispensable for in-solution digestion methods. { http://dx.doi.org/10.1016/j.jprot.2016.11.021 }

Ascites Monoclonal Antibodies

The researchers determined the role of complement on MAb-mediated protection for four mice Ig subclasses. After centrifugation of ascites fluid, Cleanascite™ protocol was implemented to remove lipids. { doi: 10.1128/IAI.70.5.2598-2604.2002 }

Cellular Response Applications

The applications and references for the many diverse investigations using Cleanascite™ upstream of cell response measurements are described in a downloadable whitepaper. { Cleanascite Cell Response Reference Applications }

Lipid Factors and Cancer Cell Aggressiveness

Cleanascite™️ helped this study show that the metabolite methylmalonic acid (MMA) complexed with lipidic structures, is a circulatory serum factor that contributes to pro-aggressive effects from an older population in cancer, The authors conclude that lipid-complexed MMA drives a more aggressive phenotype in cancer cells and as such, is a promising therapeutic target for advanced carcinomas.

Our Latest White Paper :

Cleanascite™ Lipid Removal & Cell Response Applications


We understand all sample prep challenges. Our knowledgebase is accessible to
assist our customers develop the next generation of proteomic innovation.

To learn more about it, contact sales@biotechsupportgroup.com