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HemoVoid™ Enables In-Depth Investigation of the Red Cell Proteome in Chronic obstructive pulmonary disease (COPD) A study published in the International Journal of Chronic Obstructive Pulmonary Disease entitled “Proteome Profiling of Red Blood Cells from Patients with COPD Links Proteasome Activation with Abnormal Cell Morphology and Function” Press Release
HemoVoid™ Enables In-Depth Investigation of the Red Cell Proteome in Chronic obstructive pulmonary disease (COPD)
MONMOUTH JUNCTION, NJ, September 25, 2025– A study published in the International Journal of Chronic Obstructive Pulmonary Disease entitled “Proteome Profiling of Red Blood Cells from Patients with COPD Links Proteasome Activation with Abnormal Cell Morphology and Function” provides an in-depth Red Blood Cell (RBC) proteome profile of chronic obstructive pulmonary disease (COPD). To achieve this, the investigators utilized HemoVoid™, BSG’s hemoglobin removal product, to perform a comparative proteomic analysis on RBC lysates.
“It is very rewarding to see that HemoVoid™ was essential in this analysis, as it removed the vast amount of Hemoglobin present in red cells, along with enriching the underlying low abundance proteins. It is very impressive that the study revealed 160 differentially abundant proteins between the two sample sets.” stated Dr. Swapan Roy, President and Founder of Biotech Support Group. “This highlights that our products can not only help in improving proteome coverage, but also quantification.”
For more information on HemoVoid™, visit: http://www.biotechsupportgroup.com/HemoVoid-Hemoglobin-Depletion-From-Erythrocytes-p/hvk.htm For more information of all of our Hemoglobin removal products, visit: https://www.biotechsupportgroup.com/Hemoglobin-Removal-s/312.htm
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Business Development Inquiries: Keywords: HemoVoid™, Hemoglobin depletion, Hemoglobin removal, Chronic obstructive pulmonary disease, COPD, red blood cell proteomics, proteasome, erythrocyte proteomics |
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After HemoVoid™ sample prep, total
RBC proteins were analyzed using tandem mass tag (TMT) labeling
followed by LC-MS/MS. The study identified 160 differentially
abundant proteins (DAPs) of which 70 were up-regulated, and 90
down-regulated in the RBCs of COPD patients. Notably, a
protein-protein interaction (PPI) network analysis revealed a core
complex of 10 up-regulated proteins that are all components of the
proteasome regulatory particle. These upregulated proteasomal
proteins represent a novel class of potential blood-based biomarkers.
Quantifying these proteins could offer a non-invasive means to
monitor the systemic impact and oxidative stress burden in COPD. In
conclusion, these findings reveal that the systemic pathology of COPD
is linked to RBC dysfunction and offer potential new biomarkers and
therapeutic targets.