NewsRelease
MetabolomicAnalysis Method Adopts NuGel™-HemogloBind™ in Study of Adultswith Epilepsy
MONMOUTHJUNCTION, NJ, February16, 2023 -- Biotech Support Group reports on a journal articledescribing the simplicity and efficiency of NuGel™ HemogloBind™,to remove Hemoglobin interference, in a LC-MS metabolomic analysis ofplasma in a dietary study of adults with epilepsy.
Thecitation is:
Leitner,Dominique F., et al. "Metabolomic,Proteomic, and Transcriptomic Changes in Adults with Epilepsy onModified Atkins Diet." Epilepsia (2023).
Highfat and low carbohydrate diets can reduce seizure frequency in sometreatment-resistant epilepsy patients, including the more flexibleModified Atkins Diet (MAD). Low carbohydrate diets may shift brainenergy production, particularly impacting neuron and astrocyte linkedmetabolism. The study evaluated the effect of short-term MAD onmolecular mechanisms in adult epilepsy patients from surgical braintissue and plasma compared to Control participants consuming anon-modified higher carbohydrate diet. For Plasma Metabolomics, thearticle states “Whole blood was thawed on ice and processed toremove hemoglobin by NuGel-HemogloBind according to manufacturerprotocol…samples were analyzed with the hybrid LCMS assay afterscaling metabolite extraction to 100ul/sample.”. The articleconcludes that Short-term MAD was associated with metabolicdifferences in plasma and resected epilepsy brain tissue whencompared to Control participants; there were 13 increased metabolitesin plasma that included 4.10-fold increased ketone body3-hydroxybutyric acid, decreased palmitic acid in cortex, and 11decreased metabolites in hippocampus, that had top associations withmitochondrial functions.
“Hereis another example of the versatility of NuGel™ HemogloBind™, asit is used here to clear interference in LC-MS metabolomic analysis.While NuGel™ HemogloBind™ is intended specifically for Hemoglobinremoval, a related product - NuGel™BindPro™, also can fulfill the function of a generalaqueousprotein crash reagent for metabolomic analysis.” statesSwapan Roy, Ph.D., President and Founder of Biotech Support Group.
Clickhere for more information on NuGel™ HemogloBind™
Clickhere for more information on all of our Hemoglobin Removal products
Clickhere for more information on NuGel™ BindPro™
Keywords:Epilepsy,ModifiedAtkins Diet,metabolomics, NuGel™ HemogloBind™,NuGel™ BindPro™, aqueousprotein crash
AboutBiotech Support Group LLC
Convergingwith technological disruptions forthcoming in healthcare, BiotechSupport Group continues its growth in the consumable researchproducts area supporting the rapidly expanding installation of LC-MSinstrument and computational infrastructure. For this market, keyproducts include: AlbuVoid™ and AlbuSorb™ for albumin depletion,Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™for hemoglobin removal, For more information, gotohttp://www.biotechsupportgroup.com.
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