News Release
Journal Article Cites HemoVoid™in Proteomic Study of Gaucher Disease
MONMOUTHJUNCTION, NJ, September30,2021 -- Biotech Support Group reports on a research articledescribing the simplicity and efficiency of their hemoglobindepletion technology for enriching blood proteins, in order toprofile the proteome of Gaucher disease relative to normal controls.
Thecitation is:
Pawliński,ŝukasz, et al. "Proteomicbiomarkers in Gaucher disease." Journalof clinical pathology 74.1(2021): 25-29.
Theresearch work was conducted to find new biomarkers and potential drugtargets in Gaucher disease type 1 (GDt1) by analyzing serum proteins.For proteomics,quantitativeanalysis was performed by the isobaric tag for a relative andabsolute quantitation (iTRAQ) method (Sciex, Framingham,Massachusetts). The article states “Cells were lysed in lysisbuffer (7 mol/L urea, 2 mol/L thiourea, 4% CHAPS, 1% DTT …,vortexed, incubated at 25°C for 30 min and then centrifuged at 12000×g for 15 min…the samples were purified using HemoVoid resin(Biotech Support Group) to remove haemoglobin contamination. Thestudy found 31 proteins that significantly differed in concentrationbetween GDt1 patients and a control group. These were mostly proteinsinvolved in the regulation of inflammatory processes and haemostasis.
“Throughmore efficient methods to measure the blood proteome – red cells,white cells, platelets and plasma, our products now contribute tounderstanding how these compartments cross-communicate. Thoseconnections all play a role in normal homeostasis and in disease.This article illustrates how the blood proteome can be analyzed byLC-MS, in order to discover potential new biomarkers and a betterunderstanding of Gaucher disease.”, states Swapan Roy, Ph.D.,President and Founder of Biotech Support Group.
Formore information on HemoVoid™, visit:
http://www.biotechsupportgroup.com/HemoVoid-Hemoglobin-Depletion-From-Erythrocytes-p/hvk.htm
Formore information of all of our Hemoglobin removal products, visit:
https://www.biotechsupportgroup.com/Hemoglobin-Removal-s/312.htm
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal.From these innovations, the company has acquired knowledgebase andbiomarker intellectual property assets that support discoveries ofprotein markers from blood, with special emphasis on early detectionand personalized medical decisions for Covid-19 and cancer patients.For more information, go tohttp://www.biotechsupportgroup.com
ForBusiness Development, Contact:
MatthewKuruc 732-274-2866, [email protected]