NewsRelease
HemogloBind™Cited in Forensics MultiplexProteomic Assay
MONMOUTHJUNCTION, NJ, July22, 2021 -- Biotech Support Group reports on a journal articledescribing the simplicity and efficiency of their HemogloBind™sample preparation technology for quantitative LC-MS multiplereaction monitoring (MRM) analysis. The study provides methods forthe accurate, reliable, and confirmatory identification of bodilyfluids commonly encountered in a forensic context. The citation is:
HeatherE. McKiernan, Phillip B. Danielson, Catherine O. Brown, MashaSignaevsky, Christian G. Westring and Kevin M. Legg, DevelopmentalValidation of a Multiplex Proteomic Assay for the Identification ofForensically Relevant Biological Fluids, Forensic ScienceInternational, (2021)
https://www.sciencedirect.com/science/article/pii/S0379073821002280?via%3Dihub
Theaim of this study was to validate a multiplex proteomic assay for theidentification of target peptide fragments by multiple reactionmonitoring on a triple quadrupole mass spectrometer originating fromtissue-specific proteins. Samples came from peripheral blood, semen,saliva, urine, and vaginal/menstrual fluid. Toremove the highly abundant amount of Hemoglobin in some samples, thearticle states “If samplescontained excessive quantities of hemolyzed red blood cells, fourvolumes of HemogloBind™ were added.”The authors conclude that themass spectrometry-based workflow offers significant advantagescompared to existing serological methods.
“Thelarge amount of hemoglobin in many forensic samples presents aspecial challenge for quantitative analysis. This is another exampledemonstrating again that HemogloBind™ can reduce the interferenceassociated with large concentrations of hemoglobin, withoutcompromising the recovery and analysis of the targetpeptide(s)/protein(s) of interest.” states Swapan Roy, Ph.D.,President and Founder of Biotech Support Group.
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AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, gotohttp://www.biotechsupportgroup.com.
ForBusiness Development,contact:MatthewKuruc 732-274-2866, [email protected]