Press Release

Cleanascite™ Cited in Proteomic Study of Neurodegeneration Associated with Aging

MONMOUTH JUNCTION, NJ, September 3, 2025 — Biotech Support Group (BSG) reports on its proprietary lipid removal reagent, Cleanascite™, in a mouse model study of the neuronal proteome and its turnover with aging, its propensity to aggregate, and its interaction with microglia. 

In the pre-print article led by Tony Wyss-Coray from Stanford University., entitled “Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia”, researchers leveraged mouse models to study key features of neuronal proteostasis dynamics with aging, including protein degradation, protein aggregation, and neuronal-to-microglia protein transfer, culminating in unparalleled insight into the decline of neuronal proteostasis with age and the identification of a microglia mediated mechanism of maintaining neuronal proteostasis. To characterize homogenized mouse brain tissues to evaluate proteome turnover with aging, the article states “Lipids were removed by the addition of 10 µL Cleanascite…per 40 µL homogenate…”. Upon further processing, samples were analyzed by liquid-Chromatrography – Mass Spectrometry (LC-MS) for proteomic comparisons.

The investigators discovered neuronal proteins degraded on average twice as slowly between 4- and 24-month-old mice with individual protein stability differing between brain regions. Further, they describe the aged neuronal 'aggregome' encompassing 574 proteins, nearly 30% of which showed reduced degradation. Unexpectedly, they found 274 neuronal proteins accumulated in microglia with 65% also displaying reduced degradation and/or aggregation with age. These findings reveal the dramatic loss of neuronal proteome maintenance with aging which could be causal for age-related synapse loss and cognitive decline.

“Here is an excellent example of how Cleanascite™ can be used to clear lipids from a lipid rich tissue such as brain, and that its excellent selectivity makes it ideally suited for proteomic analysis. Such an in-depth proteomic analysis required a reagent that did not interact with proteins, making a study like this possible.” stated Dr. Swapan Roy, President and Founder of Biotech Support Group.

For additional product details, visit:
Cleanascite™ Lipid Removal Reagent

About Biotech Support Group LLC
Biotech Support Group develops innovative sample preparation technologies that address the emerging needs of proteomics, biomarker discovery, and personalized medicine. Flagship products include Cleanascite™ for lipid removal, AlbuVoid™ and AlbuSorb™ PLUS for serum protein depletion, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NRicher™ for low abundance, family specific, and targeted proteome enrichment. These products support translational research by simplifying workflows and improving sample quality for downstream analysis.

For Business Development Inquiries:
Matthew Kuruc
Phone: 732-274-2866
Email: mkuruc@biotechsupportgroup.com

Keywords: Cleanascite™, lipid depletion, neuronal proteostasis, Neurodegenerative disease, brain tissue lysates, tissue proteomics