NewsRelease

Cleanascite™Cited In Study of Obesity-driven Oleoylcarnitine Accumulation inTumor Microenvironment

MONMOUTHJUNCTION, NJ, March6, 2025 -- Biotech Support Group reports on an article, describingthe simplicity and efficiency of their lipid clearance product tostudy lipid accumulation models of disease in mice.

Thecitation is:

Chen,Chao, et al. "Obesity-drivenoleoylcarnitine accumulation in tumor microenvironment promotesbreast cancer metastasis-like phenotype." ActaPharmaceutica Sinica B (2025).

Obesityis a significant risk factor for cancer and is associated with breastcancer metastasis. Nevertheless, the mechanism by which alterationsin systemic metabolism affect tumor microenvironment (TME) andconsequently influence tumor metastasis remains inadequatelyunderstood. Herein, we found that perturbations in circulatingmetabolites induced by obesity promote metastasis-like phenotypes inbreast cancer. Oleoylcarnitine (OLCarn) concentrations were elevatedin the serum of obese mice and humans. The article states “Forthe delipidation of mouse serum, Cleanascite Lipid Removal Reagent(BSG, USA) was employed following the manufacturer’s protocoldesigned specifically for serum samples. A 1:4 volume ratio ofCleanascite reagent to the sample was utilized.”. Notably,serum-deficient proteins and fats continued to induce EMT,highlighting the significance of small molecules (SupportingInformation image shown here) .The study concludes thatobesity-induced systemic environmental changes lead to the aberrantaccumulation of OLCarn within the TME, making it a potentialtherapeutic target and biomarker for breast cancer.

“Wenow have over thirty references, validating Cleanascite™ use inhelping to identify a lipid-based characteristic feature of invitrocell response. Unlike alternative lipid-depletion methods that usesolvents, Cleanascite™ is an aqueous suspension product and so itis very compatible with cellular models of disease. The essentialrequirement is the maintenance of cellular activity after lipiddepletion, to determine whether lipid factors are associated withphenotypic changes in cultured cells” states Swapan Roy, Ph.D.,President and Founder of Biotech Support Group.

Formore information visit: Cleanascite™Lipid Removal Reagent and Clarification,at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm

Keywords:Obesity,Breast cancer, Epithelial–mesenchymal transition, tumormicroenvironment, Oleoylcarnitine, Cleanascite™,lipid depletion

AboutBiotech Support Group LLC

Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for expanding proteomic analysis.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area. For this market, keyproducts include: AlbuVoid™ and AlbuSorb™ PLUS foralbumin & IgG depletion, Cleanascite™for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobinremoval, and NRicher™ for low abundance, family specific, andtargeted proteome enrichment. For more information, go tohttp://www.biotechsupportgroup.com

ForBusiness Development,contact:MatthewKuruc 732-274-2866, [email protected]