News Release

Journal Article Cites AlbuSorb™ PLUS in Plasma Proteomic Study Postpartum Dairy Cows

MONMOUTH JUNCTION, NJ, January 6, 2025 -- Biotech Support Group reports on a journal article using AlbuSorb™ PLUS in a proteomic study of how systemic inflammation negatively impacts health and production in dairy cows..

The citation is:

Grantz, Jillian M., et al. "The platelet and plasma proteome and targeted lipidome in postpartum dairy cows with elevated systemic inflammation." Scientific Reports 14.1 (2024): 31240.

Unregulated, systemic inflammation negatively impacts health and production in dairy cows. Soluble mediators and platelets have been studied for their expansive role in mediating inflammation. The objectives of this study were to compare the plasma oxylipin and endocannabinoid profiles, and the platelet and plasma proteomic profiles of healthy cows to cows experiencing elevated systemic inflammation as indicated by plasma haptoglobin (Hp) concentrations. The article states “Plasma samples were depleted of albumin using AlbuSorb™ Plus Albumin and IgG depletion Kit (APK285-20, BioTech Support Group, Monmouth Junction, NJ), following the manufacturer’s instructions.” In total, 1,016 proteins were identified in the plasma proteome. Proteomic outputs from plasma revealed 24 proteins to be different between high and low-inflammation groups, including proteins involved in autophagy and immune mediation. Together, the results indicate that cows experiencing an exacerbated systemic inflammatory response in the postpartum may have impaired disease resistance, and platelets could be contributors to their inflammatory state.

“This reference shows that AlbuSorb™ PLUS is very selective for depleting albumin and immunoglobulins in a proteomic study. Also, as our bead technology does not rely on immuno-affinity, it works for all species; cows in this example.”, states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.

For more information visit: AlbuSorb™ PLUS at
https://www.biotechsupportgroup.com/AlbuSorb-PLUS-p/apk285.htm

For more information on our complete line of Albumin & IgG Removal, visit:

https://www.biotechsupportgroup.com/Albumin-Removal-s/307.htm

Keywords

Systemic inflammation, Oxylipin, Endocannabinoid, Albumin Removal, AlbuSorb™, plasma proteomics

About Biotech Support Group LLC

Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com

Contact:
Matthew Kuruc 732-274-2866

mkuruc@biotechsupportgroup.com