Journal Article Cites HemoVoid™ in Proteomic Study of Aging Biotech Support Group reports on a research article describing the simplicity and efficiency of their hemoglobin depletion technology for enriching blood cell proteins in rhesus monkeys, in order to assess proteomic differences associated with aging by LC News Release
Journal Article Cites HemoVoid™ in Proteomic Study of Aging
MONMOUTH
JUNCTION, NJ, September
9, 2022
-- Biotech Support Group reports on a research article describing the
simplicity and efficiency of their hemoglobin depletion technology
for enriching blood cell proteins in rhesus monkeys, in order to
assess proteomic differences associated with aging by LC-MS
analysis. The citation is: Wu, Na, et al. "Proteomic characteristics of plasma and blood cells in natural aging rhesus monkeys." Proteomics: 2200049. The underlying mechanisms of aging remain unclear. This study sought to understand the aging process as it may be affected by proteins in the blood, the most important functional system for material transportation in the body. For this purpose, the investigation analyzed and compared the protein expression spectrums in the blood of old and young rhesus monkeys. To extract blood cell proteins and deplete Hemoglobin, the article states “Blood cell proteins were lysed by incubation with protein extraction solution (Bestbio, China)…for 30 minutes…After centrifugation…the supernatants were further depleted of Hemoglobin using HemoVoid™ (Biotech Support Group) as per the instructions of the manufacturer.” Upon depletion, the study found 1183 proteins expressed differentially in blood cells. The study confirmed that the protein levels of complement C2 in plasma and actin-related protein 2/3 complex subunit 2 (ARPC2) in blood cells decreased, whereas the complement C3 and complement component 4 binding protein beta (C4BPB) significantly increased in plasma of old rhesus monkeys and C57BL/6 mice. The results suggest that C2, C3, C4BPB, and ARPC2 can be used as target proteins for anti-aging research. “I am pleased to see that for Hemoglobin removal, HemoVoid™ was useful to enrich the blood cell proteome for this study. This article also illustrates an important feature for all of our products, as they are not species specific, they work on all species, in this case – rhesus monkeys”, states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.
For more information on HemoVoid™, visit: http://www.biotechsupportgroup.com/HemoVoid-Hemoglobin-Depletion-From-Erythrocytes-p/hvk.htm For more information of all of our Hemoglobin removal products, visit: https://www.biotechsupportgroup.com/Hemoglobin-Removal-s/312.htm
About Biotech Support Group LLC Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for expanding proteomic analysis. Following a tiered business strategy, the company continues its growth in the consumable research products area. For this market, key products include: AlbuVoid™ and AlbuSorb™ PLUS for albumin & IgG depletion, Cleanascite™ for lipid adsorption, and HemogloBind™ and HemoVoid™ for hemoglobin removal. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com
For
business development contact: Matthew Kuruc
Keywords Aging, proteomics, LC-MS, mass spectrometry, plasma, blood cells, rhesus monkeys |
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- BSG Products To Assist in Analyzing Macrophage Polarization
- Ectodomain Shedding and Enrichment of the Soluble Membrane Proteome
- Investigate out of the Venn Diagram box
- Methods to selectively deplete or purify Hemoglobin from Dried Blood Spots (DBS)
- The Utility of HemoVoid™ is Demonstrated in 3 Proteomic Investigations Identifying Potential Disease Specific Biomarkers
- The 4 common features of our sample prep products, known as the BSG Advantage, are highlighted in a selection of journal references.
- AlbuVoid™ Workflows Advance Cell Secretome Proteomics
- Lipid Removal for Phenotypic Cell Response in Cancer Research
- The Influence of Sample Prep Bias on LC-MS Targeted Peptide Quantification in Serum Proteomics
- Re-imagining proteomics for developing precision medicine biomarkers of the innate immune response in SARS-CoV-2
- Patent Application Describes New Proteomic Methods to Monitor Protease Inhibitor Function During Covid-19 Infections
- Efficient Hemoglobin Removal Advances Red Cell Proteomics Offering Many New Insights Into Inflammation and Infectious Disease
- The Potential for New Blood Biomarkers in the Management of COVID-19 Disease
- Establishing the Utility of HemoVoid™ and HemogloBind™ as Enrichment Tools for Proteomic Analysis of Red Cells and Whole Blood in Parkinson’s Disease
- Species Diversity Supported By BSG Products
- Poster Report Describes Loss of Functional Serpin Activity In Cancer Patient Blood
- AlbuVoid™️ PLUS & AlbuSorb™️ PLUS Evaluating Different Windows of Observation Solves The Many Challenges of Serum Proteomics
- Tackling the Challenges of Serum Proteomics
- Lipid Removal Sample Prep for Cell Response Applications
- Sample Prep for Proteomic Analysis of Saliva
- Biotech Support Group Featured in Book, "Functional Proteomics – Methods and Protocols"
- Sample Prep Liquid Biopsy Products Suitable for Proteomic Profiling of a Variety of Body Fluid Sample Types
- Albumin and High Abundance Depletion
- Using HemogloBind™ as a Hemoglobin Binding Reagent
- Diverse technologies available for researchers to selectively bind or enrich exosomes and extracellular vesicles.
- Stroma Liquid Biopsy™ Biomarkers Profile Pan-Cancer Dysregulation of the Serum Proteome
- Diverse Depletion and Enrichment Technologies Enhance Simplicity and Efficiency of Obtaining Quality Proteomic Information
- Use On-Bead Digestion to Improve Time Required for Serum Digestion
- Using AlbuVoid™ as a Serum Protein Enrichment Kit in Functional Proteomics
- Using Cleanascite™ as a Lipid Absorption and Clarification Reagent
- Using HemoVoid to Remove Hemoglobin Before Analysis
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