News Release

Journal Article Cites HemoVoid™ in Proteomic Study of Aging

MONMOUTH JUNCTION, NJ, September 9, 2022 -- Biotech Support Group reports on a research article describing the simplicity and efficiency of their hemoglobin depletion technology for enriching blood cell proteins in rhesus monkeys, in order to assess proteomic differences associated with aging by LC-MS analysis.

The citation is:

Wu, Na, et al. "Proteomic characteristics of plasma and blood cells in natural aging rhesus monkeys." Proteomics: 2200049.

The underlying mechanisms of aging remain unclear. This study sought to understand the aging process as it may be affected by proteins in the blood, the most important functional system for material transportation in the body. For this purpose, the investigation analyzed and compared the protein expression spectrums in the blood of old and young rhesus monkeys. To extract blood cell proteins and deplete Hemoglobin, the article states “Blood cell proteins were lysed by incubation with protein extraction solution (Bestbio, China)…for 30 minutes…After centrifugation…the supernatants were further depleted of Hemoglobin using HemoVoid™ (Biotech Support Group) as per the instructions of the manufacturer.” Upon depletion, the study found 1183 proteins expressed differentially in blood cells. The study confirmed that the protein levels of complement C2 in plasma and actin-related protein 2/3 complex subunit 2 (ARPC2) in blood cells decreased, whereas the complement C3 and complement component 4 binding protein beta (C4BPB) significantly increased in plasma of old rhesus monkeys and C57BL/6 mice. The results suggest that C2, C3, C4BPB, and ARPC2 can be used as target proteins for anti-aging research.

“I am pleased to see that for Hemoglobin removal, HemoVoid™ was useful to enrich the blood cell proteome for this study. This article also illustrates an important feature for all of our products, as they are not species specific, they work on all species, in this case – rhesus monkeys”, states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.

For more information on HemoVoid™, visit:

http://www.biotechsupportgroup.com/HemoVoid-Hemoglobin-Depletion-From-Erythrocytes-p/hvk.htm

For more information of all of our Hemoglobin removal products, visit:

https://www.biotechsupportgroup.com/Hemoglobin-Removal-s/312.htm

About Biotech Support Group LLC

Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for expanding proteomic analysis. Following a tiered business strategy, the company continues its growth in the consumable research products area. For this market, key products include: AlbuVoid™ and AlbuSorb™ PLUS for albumin & IgG depletion, Cleanascite™ for lipid adsorption, and HemogloBind™ and HemoVoid™ for hemoglobin removal. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com

For business development contact: Matthew Kuruc
732-274-2866 mkuruc@biotechsupportgroup.com

Keywords

Aging, proteomics, LC-MS, mass spectrometry, plasma, blood cells, rhesus monkeys