News Release
Cleanascite™Employed to Investigate Lipid influences in Melasma
MONMOUTHJUNCTION, NJ, February8, 2022 -- Biotech Support Group reports on an article, describingthe simplicity and efficiency of their lipid clearance samplepreparation technology for studying theinfluence of lipids in Melasma using co-cultures with skin explants.The citation is:
Flori,E., Mastrofrancesco, A., Mosca, S., Ottaviani, M., Briganti, S.,Cardinali, G., Filoni, A., Cameli, N., Zaccarini, M., Zouboulis,C.C., Picardo, M.,Sebocytescontribute to melasma onset,ISCIENCE (2022), doi:https://doi.org/10.1016/j.isci.2022.103871.
Melasmais a hyper-pigmentary disorder with photoaging features, whosemanifestations appear on specific face areas, rich in sebaceousglands. To verify whether sebocyte-specific lipids could contributeto the observed changes in cell lines, the investigators tested lipiddepleted irradiated SZ95 conditioned medium to treat these cells. Forthis, the BSG product Cleanascite™ was used. The article states:“Cleanascite was added to the collected SZ95 medium in a ratio 1:4and mixed for 10 min at room temperature by gentle shaking. Followingcentrifugation (16000g) for 1 min at 4 °C, the supernatant wascarefully decanted into a clean collection vial and used forexperiments.” The authors indicate sebocytes as one of the actorsin melasma pathogenesis, inducing prolonged skin cells stimulation,contributing to localized dermal aging and hyperpigmentation.
“Wehave over twenty references showing that Cleanascite™ was used tohelp identify a characteristic feature of invitrocell response. Unlike alternative lipid-depletion methods that usesolvents, Cleanascite™ is an aqueous suspension product and so itis very compatible with cellular models of disease. This ultimatelyhelps with investigations such as this, that need to determinewhether or not lipids, or factors associated with lipids, impartphenotypic changes to cells.” states Swapan Roy, Ph.D., Presidentand Founder of Biotech Support Group.
Todownload whitepaper entitled “Cleanascite™- Lipid Removal and Cell Response Applications”,visit:
Formore information visit: Cleanascite™Lipid Removal Reagent and Clarification,at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, go tohttp://www.biotechsupportgroup.com.
ForBusiness Development,contact:MatthewKuruc 732-274-2866, [email protected]