News Release
Cleanascite™Employed to Investigate Lipid-enriched Microenvironment of OvarianCancer Cells
MONMOUTHJUNCTION, NJ, December1, 2021 -- Biotech Support Group reports on an article, describingthe simplicity and efficiency of their lipid clearance samplepreparation technology for studying malignantascites in peritoneal metastases of epithelial ovarian cancer.The citation is:
Yang,X. U. A. N., et al. "SCD1/FADS2fatty acid desaturases equipoise lipid metabolic activity andredox-driven ferroptosis in ascites-derived ovarian cancer cells."(2021).
Malignantascites in peritoneal metastases is a lipid-enriched microenvironmentand is frequently involved in the poor prognosis of epithelialovarian cancer (EOC). However, the detailed mechanisms underlyingovarian cancer (OvCa) cells dictating their lipid metabolicactivities in promoting tumor progression remain elusive.
Forthis, the BSG product Cleanascite™ was used as a lipid-clearedcontrol in the investigation. The article states: “Compared withthe negative controls (OCM pretreated with the lipid removal reagent,Cleanascite), OvCa cells cocultured in the lipid-enriched OCM showedan increase of 18% in membrane fluidity.” The authors describe adisruption of the cellular redox balance and subsequent iron-mediatedlipid peroxidation in ascites-derived OvCa cells. They conclude thatcombinational treatment with SCD1/FADS2 inhibitors and cisplatinsynergistically repressed tumor cell dissemination, providing apromising chemotherapeutic strategy against EOC platinum resistanceand peritoneal metastases.
“Wehave over twenty references showing that Cleanascite™ was used tohelp identify a characteristic feature of invitrocell response. Unlike methods that use solvents, Cleanascite™ is anaqueous suspension product and so it is very compatible with cellularmodels of disease. This ultimately helps with investigations todetermine whether or not lipids, or factors associated with lipids,impart phenotypic changes to cells.” states Swapan Roy, Ph.D.,President and Founder of Biotech Support Group.
Todownload whitepaper entitled “Cleanascite™- Lipid Removal and Cell Response Applications”,visit:
Formore information visit: Cleanascite™Lipid Removal Reagent and Clarification,at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, gotohttp://www.biotechsupportgroup.com.
ForBusiness Development,contact:MatthewKuruc 732-274-2866,[email protected]