NewsRelease
JournalArticle Highlights AlbuVoid™ in Cell Secretome Proteome Analysis
MONMOUTHJUNCTION, NJ,July26, 2021 -- Biotech Support Group reports on a recent journal articlehighlighting the simplicity and efficiency of their Albumin depletionsample preparation technology for BSA containing medium used in cellculture for LC-MS proteomic analysis. The citation is:
Jenull,Sabrina, et al. "The histone chaperone HIR maintains chromatinstates to control nitrogen assimilation and fungal virulence." CellReports 36.3(2021): 109406.https://www.sciencedirect.com/science/article/pii/S2211124721008196#mmc1.
Theauthors report a pivotal role for the HIR histone chaperone complexin modulating virulence of the human fungal pathogen Candidaalbicans. Geneticablation ofHIR function alters chromatin accessibility linked to aberranttranscriptional responses to protein as nitrogen source. Thisaccelerates metabolic adaptation and increases the release ofextracellular proteases,which enables scavenging of alternative nitrogen sources. Thearticle states for “MassSpectrometry analysis of culture supernatants - Cell-freesupernatants from 16 hours YNB-BSA (0.025% BSA) cultures grown at30°C were used for Mass-Spec analysis. Collected supernatants werelyophilized and dissolved in 400 μl of water for AlbuVoid™treatment for albumin depletion…”This work provides mechanistic insights into chromatin-coupledregulatory mechanisms that fine-tune pathogen gene expression andvirulence. Furthermore, the data point toward the requirement ofrefined screening approaches to exploit chromatin modificationsas antifungal strategies.
“Iare very pleased to see that AlbuVoid™ was referenced for theproteomic analysis of cell culture secrotomes. As we do not useimmunoaffinity, separations are efficient across all speciesincluding the depletion of BSA as was the case here” states SwapanRoy, Ph.D., President and Founder of Biotech Support Group.
Formore information on AlbuVoid™,go to:http://www.biotechsupportgroup.com/AlbuVoid-Albumin-Depletion-and-Low-Abundance-p/avk.htm
Formore information on the BSG complete line of Albumin& IgG Removal products,visit:https://www.biotechsupportgroup.com/Albumin-Removal-s/307.htm
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, gotohttp://www.biotechsupportgroup.com.
Contact:MatthewKuruc 732-274-2866,[email protected]