NewsRelease
JournalArticle Cites HemoVoid™ in Etiology Study of Cancer-relatedAnemia
MONMOUTHJUNCTION, NJ, February6,2020 -- Biotech Support Group reports on a recent research articledescribing the simplicity and efficiency of their hemoglobindepletion technology for enriching the red cell proteome, in order tomeasure autoantibodies to band 3 protein in cancer patienterythrocytes.
Thecitation is:
Kitao,Akihito, et al. "Band3 ectopic expression in colorectal cancer induces an increase inerythrocyte membrane-bound IgG and may cause immune-relatedanemia." InternationalJournal of Hematology (2020):1-10.
Autoimmunehemolytic anemia (AIHA) is a rare comorbidity in colorectal cancer(CRC) and has an unknown etiology. To better understandcancer-related anemia, the authors’ investigated ectopic band 3expression and erythrocyte membrane-bound IgG in a CRC cohort. Toreduce the interference from Hemoglobin, the article states“Erythrocytes were lysed … and hemoglobin was depleted usingHemoVoid (Biotech Support Group, NJ, USA, Cat. No. HVK-10)”. Theinvestigation concluded that anti-band 3 antibody was higher in theIgG fraction of CRC patients’ compared to that of healthy controls,and that red cell membrane-bound IgG in patients with CRC, may beclinically associated to cancer-related anemia.
WholeBlood Compartments
“Throughmore efficient methods to measure the various blood components–red cells, white cells, platelets and plasma, we hope our productswill contribute to understanding how these compartmentscross-communicate. Those connections all play a role in normalhomeostasis and in disease. This article illustrates how red cellsreact to IgG, and how this interaction plays a role incancer-related anemia. For this purpose, I am pleased to see thatour product HemoVoid™ was a necessary and efficient step to removeinterferences from Hemoglobin in the Western blot analysis”,states Swapan Roy, Ph.D., President and Founder of Biotech SupportGroup.
Formore information on HemoVoid™, visit:
http://www.biotechsupportgroup.com/HemoVoid-Hemoglobin-Depletion-From-Erythrocytes-p/hvk.htm
Formore information of all of our Hemoglobin removal products, visit:
https://www.biotechsupportgroup.com/Articles.asp?ID=452
About Biotech Support Group LLC
Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com
Contact:
Matthew Kuruc 732-274-2866, [email protected]