Patent Application Highlights AlbuVoid™ in Cell-based Drug Toxicity Assays Biotech Support Group reports on a new patent application which highlights the simplicity of their albumin depletion sample preparation technology as an enrichment step for serum containing medium used in cell culture for LC-MS proteomic analysis News Release Patent
Application Highlights AlbuVoid™ in Cell-based Drug Toxicity Assays MONMOUTH
JUNCTION, NJ, October
15, 2019 -- Biotech Support Group reports on a new patent application
which highlights the simplicity and efficiency of their Albumin
depletion sample preparation technology as an enrichment step for
serum containing medium used in cell culture for LC-MS proteomic
analysis. The citation is: Narain, Niven Rajin, Rangaprasad Sarangarajan, and Vivek K. Vishnudas. "Interrogatory cell-based assays for identifying drug-induced toxicity markers." U.S. Patent Application No. 16/180,446. The
lack of reliable tools that can help with predicting toxicity early
in drug development is partly to blame for a 90% attrition of
potential compounds entering clinical development, 30% of which is
owing to poor clinical safety. Cardiotoxicity particularly is a
leading cause of drug withdrawal. The invention described is useful
for identifying markers associated with drug-induced toxicity. The
patent application states “In
one embodiment, the cells can be cultured in serum containing medium:
The volume of the medium can be reduced using 3 k MWCO Vivaspin
columns (GE Healthcare Life Sciences), then can be reconstituted with
1×PBS (Invitrogen). Serum albumin can be depleted from all samples
using AlbuVoid column (Biotech Support Group, LLC) following the
manufacturer's instructions with the modifications of buffer-exchange
to optimize for condition medium application.” The patent
description includes a novel, collaborative utilization of network
biology, genomic, proteomic, metabolomic, transcriptomic, and
bioinformatics tools and methodologies, which, when combined, may be
used to study any biological system of interest, such as obtaining
insight into the molecular mechanisms associated with or causal for
drug-induced toxicity. “I are very pleased to see that AlbuVoid™ was referenced for the proteomic analysis of cell culture. As we do not use immunoaffinity, separations are efficient across all species” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group. For more information on AlbuVoid™, go to: http://www.biotechsupportgroup.com/AlbuVoid-Albumin-Depletion-and-Low-Abundance-p/avk.htm For more information on the BSG complete line of Albumin & IgG Removal products, visit: https://www.biotechsupportgroup.com/Articles.asp?ID=451 About Biotech Support Group LLC Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com. Contact:
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- Ectodomain Shedding and Enrichment of the Soluble Membrane Proteome
- Methods to selectively deplete or purify Hemoglobin from Dried Blood Spots (DBS)
- The Utility of HemoVoid™ is Demonstrated in 3 Proteomic Investigations Identifying Potential Disease Specific Biomarkers
- The 4 common features of our sample prep products, known as the BSG Advantage, are highlighted in a selection of journal references.
- AlbuVoid™ Workflows Advance Cell Secretome Proteomics
- Lipid Removal for Phenotypic Cell Response in Cancer Research
- The Influence of Sample Prep Bias on LC-MS Targeted Peptide Quantification in Serum Proteomics
- Re-imagining proteomics for developing precision medicine biomarkers of the innate immune response in SARS-CoV-2
- Patent Application Describes New Proteomic Methods to Monitor Protease Inhibitor Function During Covid-19 Infections
- Efficient Hemoglobin Removal Advances Red Cell Proteomics Offering Many New Insights Into Inflammation and Infectious Disease
- The Potential for New Blood Biomarkers in the Management of COVID-19 Disease
- Establishing the Utility of HemoVoid™ and HemogloBind™ as Enrichment Tools for Proteomic Analysis of Red Cells and Whole Blood in Parkinson’s Disease
- Species Diversity Supported By BSG Products
- Poster Report Describes Loss of Functional Serpin Activity In Cancer Patient Blood
- AlbuVoid™️ PLUS & AlbuSorb™️ PLUS Evaluating Different Windows of Observation Solves The Many Challenges of Serum Proteomics
- Tackling the Challenges of Serum Proteomics
- Lipid Removal Sample Prep for Cell Response Applications
- Sample Prep for Proteomic Analysis of Saliva
- Biotech Support Group Featured in Book, "Functional Proteomics – Methods and Protocols"
- Sample Prep Liquid Biopsy Products Suitable for Proteomic Profiling of a Variety of Body Fluid Sample Types
- Albumin and High Abundance Depletion
- Using HemogloBind™ as a Hemoglobin Binding Reagent
- Diverse technologies available for researchers to selectively bind or enrich exosomes and extracellular vesicles.
- Stroma Liquid Biopsy™ Biomarkers Profile Pan-Cancer Dysregulation of the Serum Proteome
- Diverse Depletion and Enrichment Technologies Enhance Simplicity and Efficiency of Obtaining Quality Proteomic Information
- Use On-Bead Digestion to Improve Time Required for Serum Digestion
- Using AlbuVoid™ as a Serum Protein Enrichment Kit in Functional Proteomics
- Using Cleanascite™ as a Lipid Absorption and Clarification Reagent
- Using HemoVoid to Remove Hemoglobin Before Analysis
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