NewsRelease
NatureArticle Highlights AlbuVoid™ in Autophagy and Cancer Study
MONMOUTHJUNCTION, NJ,December13, 2018 -- BiotechSupport Group reports on a new research report which highlights thesimplicity and efficiency of their albumin depletion samplepreparation technology as an enrichment step for mouse serum LC-MSproteomic analysis. The citation is:
Poillet-Perez,Laura, et al. "Autophagymaintains tumour growth through circulating arginine."Nature(2018): 1.
Autophagyis a cellular mechanism which captures intracellular components anddelivers them to lysosomes, where they are degraded and recycled,helping cells survive during times of starvation. One in vivomodel to study autophagy is whole-body deletion of the essentialautophagy gene Atg7 in adult mice which causes a systemicmetabolic defect that manifests as starvation intolerance. In orderto measure the systemic proteomic response of such deletion in thisstudy, AlbuVoid™ was chosen as one method to remove albumin andenrich the low abundance proteomes from serum. The article states“…AlbuVoid (Biotech Support Group) was used to deplete albumin…”.This was done for the purpose of estimating differentialprotein abundances by LC-MS derived spectral counts. The serumproteomic investigation identified arginine-degrading enzyme arginaseI (ARG1) in the circulation of Atg7-deficient hosts as one ofseveral differentially identified proteins. Such evidence helped theauthors’ conclude that defective autophagy in the host leads to therelease of ARG1 from the liver and the degradation of circulatingarginine, which is essential for tumour growth; thus identifying ametabolic vulnerability of cancer.
“Iare very pleased to see that AlbuVoid™ was used for the mouse serumLC-MS analysis. Although only one piece of this very interestingautophagy puzzle, it nevertheless helped provide evidence for ametabolic vulnerability in tumors” states Swapan Roy, Ph.D.,President and Founder of Biotech Support Group.
Formore information on AlbuVoid™,go to:http://www.biotechsupportgroup.com/AlbuVoid-Albumin-Depletion-and-Low-Abundance-p/avk.htm
Formore information on the BSG complete line of Albumin& IgG Removal products,visit:https://www.biotechsupportgroup.com/Articles.asp?ID=451
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, gotohttp://www.biotechsupportgroup.com.
Contact:MatthewKuruc 732-274-2866, [email protected]