NewsRelease
ResearchArticle Cites Cleanascite™ To Study Neurodegenerative Diseases
MONMOUTHJUNCTION, NJ,December12, 2018 -- Biotech Support Group reports on a recent researcharticle describing the simplicity and efficiency of their lipidclearance sample preparation technology for studying cell responsefactors associated with cellsof the central nervous system.The citation is:
Sprenkle,Neil T., et al. "Endoplasmicreticulum stress is transmissible in vitro between cells of thecentral nervous system."Journalof Neurochemistry.
Improperprotein folding and trafficking are common pathological events inneurodegenerative diseases that result in the toxic accumulation ofmisfolded proteins within the lumen of the endoplasmic reticulum(ER). Yet the cell”extrinsicrole of sustained unfolded protein response activation underphysiological and pathological states in the central nervous system(CNS) remains to be elucidated. Theauthors studied the characteristics of a mediator secreted by ERstressed astrocytes and neurons.To determine if the mediator had lipid characteristics, thearticle states “…100μl of Cleanascite slurry was added to 1 ml of conditioned medium andincubated at RT with end-over-end mixing for 1 h followed bycentrifugation.” Theauthors provided evidence that depletionof lipids from astrocyte conditioned media using Cleanasciteabrogated transmission of ER stress. Such evidence helped the authorsconclude that ER stressed astrocytes and neurons secrete amolecule(s) with lipid characteristics which regulates bothinflammatory and ER stress responses in other astrocytes, neurons,and microglia invitro. These findingsprovide insight into the cell-nonautonomous influence of ER stress oncells of the central nervous system.
“Iam pleased that using Cleanascite™ helped to identify thecharacteristic feature of an unknown mediator of cell response. Thisdemonstrates the advantage of using an aqueous suspension productwith no harmful solvents, so one can challenge cells forresponsiveness. This ultimately helps researchers decide whether anyfactor is or is not consistent with a biomolecule having lipidcharacteristics. We highlight many references in this area on ourrecently published whitepaper.” states Swapan Roy, Ph.D., Presidentand Founder of Biotech Support Group.
Todownload whitepaper entitled “Cleanascite™- Lipid Removal and Cell Response Applications”,visit:
Formore information visit: Cleanascite™Lipid Removal Reagent and Clarification,at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, gotohttp://www.biotechsupportgroup.com.
Contact:MatthewKuruc 732-274-2866, [email protected]