NewsRelease
FunctionalProteomics Book Highlights Biotech Support Group’s Contributions tothe Field
MONMOUTHJUNCTION, NJ,October15, 2018 -- Biotech Support Group reports on a book published bySpringer, aglobal publisher that serves and supports the research community.This book seeks to fill in the current technology gap with a specificcollection of technologies developed for the study of proteinfunction at a proteome scale. Written in the Methodsin Molecular Biologyseries format, chapters include introductions, lists of materials andreagents, step-by-step protocols, and tips on troubleshooting and howto interpret results.
Thebook citation is:
Wang,X. and Kuruc, M., Functional Proteomics – Methods and Protocols,publisher Springer 2018. Thelink to purchase the book ishttps://www.springer.com/gp/book/9781493988136
Inaddition to a co-editor role, the efforts of BSG in this book arehighlighted in several chapters. First, BSG authors contributed thechapter entitled “Methods to Monitor the Functional Subproteomes ofSERPIN Protease Inhibitors”. Although SERPINs are found in avariety of functional on/off sub-forms, customarily they are observedand reported in aggregate. As a result, their influence on disease ismissed. This chapterdescribes Albumin depletion products AlbuVoid™ and AlbuSorb™and demonstrates their utility to satisfy investigations of serumSERPINs at a functional level.Linkto download chapter.
Inanother chapter entitled “Making the Case for FunctionalProteomics”, Perkins describes the research work of BSG stating,“The outcome of their work, differentiation of cancer patientsrelative to controls, is of general interest for FunctionalProteomics with a System Biology context…The analysis of theirfindings…deemed Stroma Liquid Biopsy, however, goes far beyondcreating a simple list of differentiating proteins. Proteins fromthree interconnected pathways of networks emerged. Further,differentiation is heavily dependent on posttranslationalmodifications and control mechanisms of those modifications”.
Finally,in the chapter entitled “Proteases: Pivot Points in FunctionalProteomics, authors Verhamme, Leonard, and Perkins describe BSG’spioneering biomarker efforts in uncovering biological networks,rather than single entities. They write “…for cancer, ‘StromaLiquid Biopsy™’ demonstrates a network (or pattern) - basedanalysis of LC/MS data, connecting multiple networks or pathways thatrely profoundly on proteolytic activity (coagulation, complement, andinflammation)…Further, the identified subproteome(s) become arelevant test bed for screening new therapeutics”.
“Thisbook represents a large body of our work, and underlies ourcommitment to all the endeavors of functional proteomics, startingwith sample preparation all the way to functional networks. The booksupports our belief that proteomicenrichment products are foundational for the functional andstructural proteomic analyses necessary to characterize andultimately to generate useful biomarkers for disease.”states Swapan Roy, Ph.D., President and Founder of Biotech SupportGroup.
Formore information on Albumin Removal products, visit:
https://www.biotechsupportgroup.com/Articles.asp?ID=451
Formore information on Stroma Liquid Biopsy™, visit:
https://www.biotechsupportgroup.com/Articles.asp?ID=543
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, gotohttp://www.biotechsupportgroup.com
Contact:
MatthewKuruc 732-274-2866, [email protected]