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NuGel™ Poly-Hydroxy

NuGel™  Poly-Hydroxy


Base Price: $510.00

Product Code: NPHX-20


NuGel™ Poly-Hydroxy For Immobilization

  • Non-specific sites are virtually eliminated by a polymer coating
  • Stable across a wide pH range 2 – 10
  • 1000Å, 50µm Silica suitable for LC and batch processes
  • Applications include: Enzyme immobilization, separation and purification of biopolymers, immobilization of proteins & ligands – monoclonal antibodies, hormones, peptides, haptens, drugs, etc

Silica has been an industry standard as an advantageous matrix suitable for high performance liquid chromatography. With NuGel™, non-specific sites have been virtually eliminated making it an ideal support for affinity purification. Through a proprietary polymer coating, Silica is crosslinked forming a reactive Poly-Epoxy functionality stable across a wide pH range (pH 2 to 10). From this foundational chemistry, all of the NuGel™ affinity products are derived.

NuGel™ Poly-Hydroxy Technical Data

NuGel™ Polyhydroxy support has a terminal glycol group(cis-diol). This alpha glycol group can be activated either by sodium-m-periodate to form active aldehyde groups at the end or by a variety of leaving groups such as carbonyldiimidazole, chloroformates, sulfonates, etc. These leaving groups are easily replaced by nucleophilic ligands containing amino and thiol groups.

Technical Data
Spacer ArmPolymerized hydrophilic carbon chain
Average Particle Size50um
Substitution Level100-200 uEq/gm of Hydroxy groups

Special Features:

  • Couples ligands containing free terminal glycol groups in the presence of a Carbonyl diimidazole.
  • Couples non-polar ligands in organic solvents.
  • pH stable from 2 to 9.

Click Here To View NuGel™ Poly-Hydroxy Product Sheet