NuGel™ Poly-Aldehyde

NuGel™ Poly-Aldehyde For Immobilization

• Couples with ligand containing amino groups.
• Non-specific sites are virtually eliminated by a polymer coating
• Stable across a wide pH range 2 – 10
• 1000Å, 50µm Silica suitable for LC and batch processes
• Application include:
  • Immobilization of proteins,enzymes, monoclonal antibodies etc.
  • Immobilization of small ligands for example: hormones, peptides, haptens etc.

Silica has been an industry standard as an advantageous matrix suitable for high performance liquid chromatography. With NuGel™, non-specific sites have been virtually eliminated making it an ideal support for affinity purification. Through a proprietary polymer coating, Silica is crosslinked forming a reactive Poly-Epoxy functionality stable across a wide pH range (pH 2 to 10). From this foundational chemistry, all of the NuGel™ affinity products are derived.

Technical Data

NuGel™ Poly-Aldehyde is a derivative of NuGel™ polyhydroxy affinity support. This affinity support contains aldehyde groups at the end of hydrophilic spacer arms and is used to couple ligands containing amino groups.

Special Features:

• Immobilization of protein, independent of pl.
• Immobilization of amino ligands.
• Immobilization can be achieved at any pH between 4 and 9.
• Protein binding capacity:
  • Murine IgG: 5-10mg per gram of support
  • Sheep serum: 5-10mg per gram of support