BindPro™ For Drug Binding/Screening, Metabolomics and Protein Recovery

Lipoproteins
Wolbachia Lipoprotein Stimulates Innate and Adaptive Immunity through Toll-like Receptors 2 and 6 to Induce Disease Manifestations of Filariasis Joseph D. Turner J. Biol. Chem. 2009 284: 22364-22378.
BindPro™ can eliminate the artifacts of protein contamination and improve study of amino acids, sugars, lipids, nucleotides, and other biomolecules from biological tissues and fluids. In this article, researchers used Cleanascite™ first to determine if TLR2/6 ligands of Wolbachia are lipoproteins for removing lipids and lipoproteins. Next BindPro™, a polymeric protein removal suspension reagent (Biotech Support Group)was used to ablate levels of HEK-TLR2 cell IL-8 reporter gene activity to BMFE thereby showing that the TLR2/6 activity depends on both lipid and protein moieties.
BindPro™-Protein Removal for Drug Screening & Metabolomics from Biotech Support Group

Patent
Bhogal, John, Shridhara Alva Karinka, Timothy P. Henning, David Cunningham, Udo Hoss, Andrew H. Naegeli, and John Latour. "Methods of Collecting and Analyzing Samples." U.S. Patent 20,120,296,189, issued November 22, 2012.
Inventors John Bhogal, Alva Karinka, Timothy Henning, David Cunningham, Udo Hoss, Andrew Naegeli, John Latour and assignee Abbott Diabetes Care Inc published United States Patent Application 20120296189 titled, Methods of Collecting and Analyzing Samples. The patent cites BindPro™ from Biotech Support Group and details a method for measuring interstitial fluid glucose concentration via ion chromatography. The patent describes methods for measuring analyte concentrations in interstitial fluid samples and methods of extracting interstitial fluid.
For detailed protocols of the published article click
http://www.freepatentsonline.com/y2012/0296189.html