NewsRelease
Cleanascite™Employed to Investigate Lipid Influence in MacrophageMaturation in Cancer
MONMOUTHJUNCTION, NJ, March9, 2022 -- Biotech Support Group reports on an article, describingthe simplicity and efficiency of their lipid clearance technology fordepletionof lipids in monocyte cultures prepared with supernatants from cancercell lines. Thecitation is:
Albakri,Marwah M., et al. "Fattyacids secreted from head and neck cancer induce M2”likeMacrophages." Journalof Leukocyte Biology (2022).
Tumor-infiltratingmonocytes can mature into Macrophages that support tumor survival orthat display antitumor properties. To explore mechanisms steeringMacrophage maturation, the authors assessed the effects ofsupernatants from squamous cell carcinoma cell lines (FaDu and SCC)on monocyte-derived Macrophage maturation. To assess depletion offatty acids from tumor supernatants, tumor-conditioned medium wastreated with Cleanascite according to the manufacturer’sinstructions and prior to incubation with monocytes. The articlestates “Depletion of Fatty acids with Cleanascite from FaDu or SCCsupernatants largely reversed the phenotypic changes in Macrophagesotherwise observed by incubating monocytes in these supernatants”.Macrophages incubated with either palmitic acid or oleic aciddeveloped similar phenotypes as cells incubated in tumorsupernatants. The authors conclude that fatty acids are sufficient tomediate monocyte skewing towards M2-like cells.
“Wenow have over twenty references, many investigating cancer, showingthat Cleanascite™ was used to help identify a characteristicfeature of invitrocell response. Unlike alternative lipid-depletion methods that usesolvents, Cleanascite™ is an aqueous suspension product and so itis very compatible with cellular models of disease. This ultimatelyhelps with investigations such as this, that need to determinewhether or not lipids, or factors associated with lipids, impartphenotypic changes to cells.” states Swapan Roy, Ph.D., Presidentand Founder of Biotech Support Group.
Todownload whitepaper entitled “Cleanascite™- Lipid Removal and Cell Response Applications”,visit:
Formore information visit: Cleanascite™Lipid Removal Reagent and Clarification,at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal.From these innovations, the company has acquired knowledgebase andbiomarker intellectual property assets that support discoveries ofprotein markers from blood, with special emphasis on early detectionand personalized medical decisions for cancer patients. For moreinformation, go tohttp://www.biotechsupportgroup.com.
ForBusiness Development, contact:MatthewKuruc 732-274-2866, [email protected]