News Release

Journal Article Cites Cleanascite™ in Study of a Traditional Chinese Medicine As Anticancer Agent

MONMOUTH JUNCTION, NJ , September 3, 2020 -- Biotech Support Group reports on an article describing the simplicity and efficiency of their lipid clearance sample preparation technology to investigate a bioactive protein- MAP30, isolated from bitter melon seeds, as a potent anticancer and anti-chemoresistant agent in ovarian cancer cells . The citation is:

Chan DW, Yung MM, Chan Y-Sang, Xuan Y, Yang H, Xu D, Zhan J-Biao, Chan KK, Ng T-Bun, Ngan HY, MAP30 protein from Momordica charantia is therapeutic and has synergic activity with cisplatin against ovarian cancer in vivo by altering metabolism and inducing ferroptosis, Pharmacological Research (2020), doi: https://doi.org/10.1016/j.phrs.2020.105157

Increasing evidence shows that Traditional Chinese Medicine has an obvious appeal for cancer treatment, but there is still a lack of scientific investigation of its underlying molecular mechanisms. Bitter melon or bitter gourd (Momordica charantia) is an edible fruit that is commonly consumed, and it is used to cure different diseases in various ancient folk medical practices. The investigators report that a bioactive protein, MAP30, isolated from bitter melon seeds exhibited potent anticancer and anti-chemoresistant effects on ovarian cancer cells. To support the analysis of MAP30 altering glycolysis and lipid metabolism in ovarian cancer cells, the authors state “Nile Red fluorescence of lipid-loaded ES2 (human epithelial ovarian cancer cells) in OCM culture for 48 h. …OCM (Omental conditioned medium) with Cleanascite™ treatment were used as negative controls.”. The authors conclude that natural MAP30 is a non-toxic supplement that may enhance chemotherapeutic outcomes and benefit ovarian cancer patients with peritoneal metastases.

“Cleanascite™ has become the go-to product for lipid removal in the most challenging applications. Whenever an investigation needs to consider whether lipids influence cell culture response, Cleanascite™ can be used, as it is an aqueous suspension product without harmful solvents, and does remove other non-lipid factors which may influence cell response. This ultimately helps researchers decide whether or not lipids, or factors interacting with lipids, impart characteristic changes in cells. In this citation, the investigators used Cleanascite™ as a negative control, to better understand how their natural product influenced cancer cell lines.” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group .

To download whitepaper entitled “ Cleanascite™ - Lipid Removal and Cell Response Applications ”, visit:

https://www.biotechsupportgroup.com/v/vspfiles/templates/257/pdf/Cleanascite-Cell-Response-Reference-Applications-090320.pdf

For more information visit: Cleanascite™ Lipid Removal Reagent and Clarification, at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm

About Biotech Support Group LLC

Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com.

For Business Development , contact: Matthew Kuruc 732-274-2866 , mkuruc@biotechsupportgroup.com