NewsRelease
JournalArticle Cites Cleanascite™ in Study of a Traditional ChineseMedicine As Anticancer Agent
MONMOUTHJUNCTION, NJ,September3, 2020 -- Biotech Support Group reports on an article describing thesimplicity and efficiency of their lipid clearance sample preparationtechnology to investigate a bioactive protein- MAP30, isolated frombitter melon seeds, as a potent anticancer and anti-chemoresistantagent in ovarian cancer cells.The citation is:
ChanDW, Yung MM, Chan Y-Sang, Xuan Y, Yang H, Xu D, Zhan J-Biao, Chan KK,Ng T-Bun, Ngan HY, MAP30 protein from Momordica charantia istherapeutic and has synergic activity with cisplatin against ovariancancer in vivo by altering metabolism and inducing ferroptosis,Pharmacological Research (2020), doi:https://doi.org/10.1016/j.phrs.2020.105157
Increasing evidence shows that Traditional Chinese Medicine has an obvious appeal for cancer treatment, but there is still a lack of scientific investigation of its underlying molecularmechanisms. Bitter melon or bitter gourd (Momordica charantia) is anedible fruit that is commonly consumed, and it is used to curedifferent diseases in various ancient folk medical practices. Theinvestigators report that a bioactive protein, MAP30, isolated frombitter melon seeds exhibited potent anticancer andanti-chemoresistant effects on ovarian cancer cells. To support theanalysis of MAP30 altering glycolysis and lipid metabolism in ovariancancer cells, the authors state “Nile Red fluorescence oflipid-loaded ES2 (human epithelial ovarian cancer cells) in OCMculture for 48 h. …OCM (Omental conditioned medium) withCleanascite™ treatment were used as negative controls.”. Theauthors conclude that natural MAP30 is a non-toxic supplement thatmay enhance chemotherapeutic outcomes and benefit ovarian cancerpatients with peritoneal metastases.
“Cleanascite™has become the go-to product for lipid removal in the mostchallenging applications. Whenever an investigation needs to considerwhether lipids influence cell culture response, Cleanascite™ can beused, as it is an aqueous suspension product without harmfulsolvents, and does remove other non-lipid factors which may influencecell response. This ultimately helps researchers decide whether ornot lipids, or factors interacting with lipids, impart characteristicchanges in cells. In this citation, the investigators usedCleanascite™ as a negative control, to better understand how theirnatural product influenced cancer cell lines.” states Swapan Roy,Ph.D., President and Founder of Biotech Support Group.
Todownload whitepaper entitled “Cleanascite™- Lipid Removal and Cell Response Applications”,visit:
Formore information visit: Cleanascite™Lipid Removal Reagent and Clarification,at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, go tohttp://www.biotechsupportgroup.com.
ForBusiness Development,contact:MatthewKuruc 732-274-2866, [email protected]