NewsRelease
JournalArticle Cites Cleanascite™ To Deplete Extracellular Vesicles
MONMOUTHJUNCTION, NJ,June14, 2018 -- Biotech Support Group reports on a recent journal articledescribing the simplicity and efficiency of their lipid bindingsample preparation technology for depleting the influence ofextracellular vesicles – also known as EVs or exosomes, oncell-cell communication. The citation is:
Nguyen,Doan C., et al. "Extracellularvesicles from bone marrow-derived mesenchymal stromal cells supportex vivo survival of human antibody secreting cells."Journalof extracellular vesicles7.1 (2018): 1463778.
Bonemarrow-derived mesenchymal stromal cells (MSC) have been shown tosupport human antibody secreting cells (ASC) survival exvivo. Extracellularvesicles from bone marrow-derived mesenchymal stromal have novelmechanisms of cell-cell communication over short and long distances,but whether the crosstalk between these cell interactions can occurvia extracellular vesicles is not known. Thus, the study investigatedthe role of extracellular vesicles (EVs) in antibody secreting cellsurvival and IgG secretion. The article states “Tounderstand whether disrupting the lipid plasma membrane that upsetsthe integrity of the EVs would compromise the survival activity ofeither the non-irradiated or irradiated secretomes, …We thencultured ASC with conventional media (vehicle), secretome fromirradiated MSC, or secretome from irradiated MSC that had beenpretreated with the lipid-disrupting agent Cleanascite [28],which is known not to alter protein functionality [29].Cleanascite-treatment of the secretome dramatically reduced ASCfunctional survival, … Similar reductions were also noted with thesecretome of non-irradiated MSC when treated with Cleanascite …These results demonstrate that lipid-membrane bodies, such as EVs,could mediate important ASC survival factors within the MSCsecretome.”
“Thisreference shows that Cleanascite™can simply and efficiently bind the lipid membrane complex necessaryfor studying extracellular vesicle communication between cells. Thisdemonstrates the advantage of using an aqueous suspension productwith no solvents, to deplete lipid associated factors that mayinfluence cell response investigations. The exosome depletion isquite impressive” states Swapan Roy, Ph.D., President and Founderof Biotech Support Group.
Formore information visit: Cleanascite™Lipid Removal Reagent and Clarification,at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, gotohttp://www.biotechsupportgroup.com
Contact:
MatthewKuruc 732-274-2866