MONMOUTHJUNCTION, NJ, April17,2018 -- Biotech Support Group reports on a recent research articledescribing the simplicity and efficiency of their hemoglobindepletion technology for enriching the red cell proteome, from fishnucleated red blood cells.

Thecitation is:

Puente-Marin,Sara, et al. "InSilico Functional Networks Identified in Fish Nucleated Red BloodCells by Means of Transcriptomic and Proteomic Profiling."Genes9.4 (2018): 202.

Nucleatedred blood cells (RBCs) of fish have, in the last decade, beenimplicated in several immune-related functions, such as antiviralresponse, phagocytosis or cytokine-mediated signaling. Label-freeshotgun proteomic analyses were carried out for in silico functionalpathway profiling of rainbow trout RBCs. Thearticle states “Thecytosolic fraction, approximately 300 μL, was depleted of hemoglobinusing HemoVoid^TMkit (Biotech Support Group, Monmouth Junction, NJ, USA), inaccordance with the manufacturer’s instructions”.The authors conclude that by combiningtranscriptome- and proteome- sequencing data in silico, novel andstriking immune functional networks for rainbow trout nucleated RBCs,which are mainly linked to innate and adaptive immunity. Thesepreliminary findings further implicate nucleated RBCs in immunefunction, such as antigen presentation and leukocyte activation. 

“Thisarticle illustrates that our proteomic enrichment products work veryefficiently for all species, even non-mammals, as they do not rely onantibodies. The ability to enrich for the underlying sub-proteomefrom the cytosolic fraction of red cells is a unique feature ofHemoVoid™. That LC-MS/MS proteomeprofiling identified 1.770 proteins, where 724 proteins had more than2 PSMs,demonstrates itsusefulness in proteomic investigations” states Swapan Roy, Ph.D.,President and Founder of Biotech Support Group.  

Formore information on HemoVoid™, visit:

http://www.biotechsupportgroup.com/HemoVoid-Hemoglobin-Depletion-From-Erythrocytes-p/hvk.htm

AboutBiotech Support Group LLC

Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ for lipidadsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NuGel™ for functional proteomics. From these innovations, thecompany has acquired knowledgebase and biomarker intellectualproperty assets that support discoveries of protein markers fromblood, with special emphasis on early detection and personalizedmedical decisions for cancer patients. For more information, gotohttp://www.biotechsupportgroup.com

Contact:
MatthewKuruc 732-274-2866, [email protected]