NewsRelease
ResearchArticle Cites Cleanascite™ for Mass Spectrometric ProteomeAnalysis of Human Bile Fluid
MONMOUTHJUNCTION, NJ,January4, 2017 -- Biotech Support Group reports on a recent research articledescribing the simplicity and efficiency of their proteomic samplepreparation technology for clearing lipids from bile fluid.
Thecitation is:
Megger,Dominik A., et al. "One Sample, One Shot-Evaluation of samplepreparation protocols for the mass spectrometric proteome analysis ofhuman bile fluid without extensive fractionation." Journalof Proteomics(2016). http://dx.doi.org/10.1016/j.jprot.2016.11.021
Inbrief, the article’s authors report methods to overcome thebiological variability of analyzing a high number of bile samples.They advance that easy sample preparation protocols are demandedrepresenting a compromise between proteome coverage and simplicity inthis study. For this, they evaluated the performance of simpleworkflows allowing for "one sample, one shot" experimentsto identify biomarker candidates for various diseases of thehepatobiliary system. In detail, sixteen different protocols withmodifications at the stages of desalting, delipidation,deglycosylation and tryptic digestion were examined. The articlestates “For delipidation, the Cleanascite™ Lipid RemovalReagent and Clarification Kit (BSG, NJ 08852, USA) was used followingmanufacturer's instructions.”. The authors concluded thatdelipidation yielded a considerable number of complementary proteinidentifications and that Cleanascite™ treatment wasindispensable for in-solution digestion methods.
“Iam very pleased we now have many references for Cleanascite™demonstrating its effectiveness to very selectively remove lipidsfrom bile fluid, as this is will become a very important proximalbody fluid for biomarker screenings in disease studies.” statesSwapan Roy, Ph.D., President and Founder of Biotech Support Group.
Formore information visit: Cleanascite™Lipid Removal Reagent and Clarification,at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm
AboutBiotech Support Group LLC
Convergingwith cultural and technological disruptions forthcoming inhealthcare, Biotech Support Group develops methods for cost effectiveand efficient sample prep essential for these expanding markets.Following a tiered business strategy, the company continues itsgrowth in the consumable research products area supporting therapidly expanding installation of LC-MS instrument and computationalinfrastructure. For this market, key products include: AlbuVoid™and AlbuSorb™ for albumin depletion, Cleanascite™ forlipid adsorption, HemogloBind™ and HemoVoid™ forhemoglobin removal, and NuGel™ for functional proteomics. Fromthese innovations, the company has acquired knowledgebase andbiomarker intellectual property assets that support discoveries ofprotein markers from blood, with special emphasis on early detectionand personalized medical decisions for cancer patients. For moreinformation, go tohttp://www.biotechsupportgroup.com
Contact:
Matthew Kuruc 732-274-2866