SeraFILE Separations Platform For Functional Proteomic Profiling of Phosphodiesterases described in International Journal of Proteomics article

SeraFILE Separations Platform For Functional Proteomic Profiling of Phosphodiesterases described in International Journal of Proteomics article

Monmouth Junction, NJ, – ProFACT Proteomics and its partner in research consumables, Biotech Support Group LLC, reports on a new journal article which describes the use of SeraFILE™, a proprietary protein separations platform. The article illustrates how SeraFILE™ is used to efficiently produce unique subproteomes, with resulting enzyme measurements integrated into molecular profiles. The results demonstrate that the proposed methods provide a means to simplify intersample differences, and to localize proteins attributable to sample-specific responses.

The citation is:
Functional Proteomic Profiling of Phosphodiesterases Using SeraFILE Separations Platform, International Journal of Proteomics, vol. 2012, Article ID 515372, 8 pages, 2012. doi:10.1155/2012/515372.

You may directly access this article at

“This research demonstrates that our unique approach to functional proteomics can break down complex proteomes into subproteomes and by doing this, compartmentalize an enriched fraction associated with disease. Deeper LC-MS characterization of these fractions can help identify prospective biomarkers. Furthermore, the same approach can index the effects of drug modulation and we hope to further exploit these SeraFILE™ applications to create a bulls-eye effect for drug repurposing.” states Matthew Kuruc, President of ProFACT Proteomics.

For more information about SeraFILE PROspector™, click:
SeraFILE PROspector™ – Differentiated Subproteomes and Enrich Functional Biomarkers

About Biotech Support Group LLC

Biotech Support Group LLC is a leading provider of genomics and proteomics sample preparation products and enrichment reagent kits as well as integrated biotechnology services for life sciences research, biomarker and drug discovery. Based in New Jersey, it’s principal products include: Albusorb™ for albumin depletion, AlbuVoid™ for albumin depletion plus low abundance serum protein enrichment, Cleanascite™ for lipid adsorption and clarification, NuGel™ for passivated silica-based affinity chromatography, and ProCipitate™ & ProPrep™ for nucleic acid isolation. Biotech Support Group is the leading developer of sample preparation products for separating and purifying hemoglobin from blood samples. HemoVoid™ is a hemoglobin depletion reagent kit from red blood cells and HemogloBind™ is a hemoglobin capture reagent from hemolyzed serum. Currently, Biotech Support Group LLC and ProFACT Proteomics Inc., are collaborating on the development of a proteomics platform used in functional profiling for proteomic analysis and a separations method for generating sub-proteomes used in biomarker and functional proteomic prospecting. For more information, go to:

About ProFACT Proteomics

ProFACT Proteomics, Inc. is a privately held early-stage corporation which applies its enabling proprietary Proteomics technology, for development of therapeutics, biomarkers and personalized medicine. Through partnership and service agreements, ProFACT participates in 4 related platform areas: SeraFILE™, for reduction of protein complexity and sub-proteome creation; Functional Proteome Prospecting™, to enrich and isolate functional activity; Conformerics™, to profile protein drug responsiveness from natural sources; and Rational Genome to Proteome Prospecting™, for prospecting into protein expression based on gene expression data. For more information, please visit

Dr.Swapan Roy
Biotech Support Group
1 Deer Park Drive, Suite M,
Monmouth Junction, NJ 08852, USA

Matthew Kuruc
ProFACT Proteomics

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Posted on Date:
Sat, 12/01/2012