NuGel™ products perform optimally using new on-bead digestion for LC-MS

January 9, 2013, MONMOUTH JUNCTION, NJ- Biotech Support Group reports on a recent development for its line of NuGel™ and related products. With greater interest in the proteomics community for better workflows and performance for LC-MS analyses, affinity separations have often been coupled to direct proteolytic digestion of the bound protein content. This is commonly called “on-bead digestion” in the literature. Biotech Support Group has extended the benefits of on-bead digestion to include its low abundance enrichment products that deplete the high abundance proteins by selective voidance – AlbuVoid™ in the case of albumin from serum/plasma, and HemoVoid™ in the case of hemoglobin from red cell lysates and whole blood. For urine proteins, the UPCK™ Urine Protein Enrichment/Concentration Kit concentrates the proteins sufficiently for on-bead digestion. Furthermore, these same on-bead digestion protocols extend to its affinity sorbents such as KinaSorb™ – for kinases, PDEnRich™ for cyclic nucleotide phosphodiesterases, NuGel™ Glycoprotein Enrichment PBA Kit – With Phenyl Boronic Acid Matrix for glycoproteins, and the NuGel™ covalent chemistries for immobilizing affinity ligands.

“These developments support our efforts to supply ideal enrichment and affinity products for LC-MS proteomics analysis. Our NuGel™ products are different from other protein separations products which are mostly derived from carbohydrate architectures. By contrast, the NuGel™ products are derived from a unique polymer-coated porous silica, which is rigid with a low water content, ideal for concentration and proteolytic digestion. Because of its passivation, the non-specific protein binding is virtually eliminated” states Swapan Roy, Ph.D., President of Biotech Support Group.

For more information, visit:
http://biotechsupportgroup.com/node/374/

About Biotech Support Group LLC

Biotech Support Group LLC is a leading developer of proteomic and genomic sample preparation and enrichment products. Its principal products include: AlbuVoid™ for albumin depletion, Cleanascite™ for lipid adsorption and clarification, HemogloBind™ & HemoVoid™ for hemoglobin removal, NuGel™ for functional & chemical proteomics, and ProCipitate™ & ProPrep™ for nucleic acid isolation. For more information, go to www.biotechsupportgroup.com.

CONTACTS:

Dr. Swapan Roy & Matthew Kuruc
Biotech Support Group LLC
1 Deer Park Drive, Suite M
Monmouth Junction NJ 08852
732-274-2866 Worldwide
800-935-0628 North America
sales@biotechsupportgroup.com
http://www.biotechsupportgroup.com