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Research Article Cites HemogloBind™ in Cholinesterase Analysis for Evaluating Oxime Therapies News Release MONMOUTH JUNCTION, NJ, November 14, 2014 — Biotech Support Group reports on a recent research article which describes the simplicity and efficiency of their proteomic sample preparation technology for hemoglobin depletion. The citation is: Acetylcholine is an essential neurotransmitter, and inhibitors of cholinesterases(ChEs) are potent toxins. The objective of the present study is to identify an oxime antidote, under standardized and comparable conditions, that offers protection against chemical warfare agents or pesticides. Clinical signs of toxicity were observed for 24 h post challenge and blood cholinesterase [AChE and butyrylcholinesterase (BChE)] activity was analyzed utilizing a modified Ellman’s method. In the modified Ellman’s enzymatic assay for evaluating ChE activity, HemogloBind™, Biotech Support Group’s unique solid-phase polymer for hemoglobin depletion, was used for pre-treatment. The article states “Terminal blood samples were collected and processed for all survivors using HemogloBind™”.
“As hemoglobin interference is common in many enzymatic assays, I am pleased to see the successful use of HemogloBind™for both efficient hemoglobin depletion along with retention of functional activity post-treatment.” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.
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Posted on Date:
Tue, 11/18/2014
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