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Two Research Reports Cite HemogloBind™ for Highly Efficient Sample Prep News Release MONMOUTH JUNCTION, NJ, November 17, 2015 — Biotech Support Group reports on two recent research reports which describe the simplicity and efficiency of their proteomic sample preparation technology for hemoglobin depletion. The first citation is: Acetylcholine is an essential neurotransmitter, and inhibitors of cholinesterases(ChEs) are potent toxins. A primary component of anti-organophosphorus therapy is an oxime reactivator to rescue inhibited acetylcholinesterases. For this, clinical signs of toxicity can be measured from blood cholinesterase [Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)] activity utilizing a modified Ellman’s method. Biotech Support Group’s unique solid-phase polymer for hemoglobin depletion, was used for pre-treatment. The article states “Briefly, whole blood samples were treated with HemogloBind™ which interferes with the ChE activity assay due to spectral overlap.” The second citation is: Protein expression in the Bronchoalveolar lavage fluid (BALF) from subjects with Acute Respiratory Distress Syndrome was evaluated. The BALF samples were processed by desalting, concentration and removal of high abundance proteins. The protein fractions were trypsin digested and labeled with the iTRAQ reagent for mass spectrometry (MS). The thesis states “BALF samples containing at least 1.2 mg of proteins were processed for LCMS/MS…concentrated and desalted using Amicon 3-MWCO filters. “These two reports highlight essential features of HemogloBind™. First is that the separations do not pose any functional or structural changes to the proteins being analyzed. Second is the excellent selectivity profile which allowed almost a 2X increase compared to not having used HemogloBind™, to an impressive total of 845 total proteins identified.” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group. About Biotech Support Group LLC Contact: |
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