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Journal Article Cites HemogloBind™ in Research on Human Abdominal Aortic Aneurysms MONMOUTH JUNCTION, NJ, November 30, 2015 — Biotech Support Group reports on a journal article reports which describe the simplicity and efficiency of their proteomic sample preparation technology for hemoglobin depletion. The citation is: Rubio-Navarro et al. Hemoglobin induces monocyte recruitment and CD163-macrophage polarization in abdominal aortic aneurysm. International Journal of Cardiology 201 (2015) 66–78. Hemoglobin (Hb) is a strong oxidant catalyst that could lead to cell damage in the arterial wall. To restrain these harmful effects, Hb is cleared by CD163, a scavenger receptor present on the surface of circulating monocytes and tissue macrophages. A soluble form of CD163 (sCD163) has been also reported in plasma. The role of Hb on monocyte recruitment and differentiation towards CD163 expressing macrophages in human abdominal aortic aneurysms (AAA) was investigated. The authors conclude that the presence of Hb in the adventitial AAA-wall promotes the migration and differentiation of activated circulating monocytes in AAA patients, as such effects were partially suppressed when Hb was removed by the use of HemogloBind™. The article states “Conditioned medium from healthy aortas or AAA samples were treated with HemogloBind™ reagent (Biotech Support Group LLC) according to the manufacturer’s protocol for hemoglobin depletion. HemogloBind™ is a polyelectrolyte mixture designed to selectively bind hemoglobin from biological fluids.”. “This report illustrates the essential features of HemogloBind™, that the selectivity profile is exquisite and that after Hemoglobin removal – bio-activity, as exemplified by cellular response, remains.” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.
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Posted on Date:
Thu, 04/16/2015
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- Ectodomain Shedding and Enrichment of the Soluble Membrane Proteome
- Methods to selectively deplete or purify Hemoglobin from Dried Blood Spots (DBS)
- The Utility of HemoVoid™ is Demonstrated in 3 Proteomic Investigations Identifying Potential Disease Specific Biomarkers
- The 4 common features of our sample prep products, known as the BSG Advantage, are highlighted in a selection of journal references.
- AlbuVoid™ Workflows Advance Cell Secretome Proteomics
- Lipid Removal for Phenotypic Cell Response in Cancer Research
- The Influence of Sample Prep Bias on LC-MS Targeted Peptide Quantification in Serum Proteomics
- Re-imagining proteomics for developing precision medicine biomarkers of the innate immune response in SARS-CoV-2
- Patent Application Describes New Proteomic Methods to Monitor Protease Inhibitor Function During Covid-19 Infections
- Efficient Hemoglobin Removal Advances Red Cell Proteomics Offering Many New Insights Into Inflammation and Infectious Disease
- The Potential for New Blood Biomarkers in the Management of COVID-19 Disease
- Establishing the Utility of HemoVoid™ and HemogloBind™ as Enrichment Tools for Proteomic Analysis of Red Cells and Whole Blood in Parkinson’s Disease
- Species Diversity Supported By BSG Products
- Poster Report Describes Loss of Functional Serpin Activity In Cancer Patient Blood
- AlbuVoid™️ PLUS & AlbuSorb™️ PLUS Evaluating Different Windows of Observation Solves The Many Challenges of Serum Proteomics
- Tackling the Challenges of Serum Proteomics
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- Biotech Support Group Featured in Book, "Functional Proteomics – Methods and Protocols"
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- Using HemogloBind™ as a Hemoglobin Binding Reagent
- Diverse technologies available for researchers to selectively bind or enrich exosomes and extracellular vesicles.
- Stroma Liquid Biopsy™ Biomarkers Profile Pan-Cancer Dysregulation of the Serum Proteome
- Diverse Depletion and Enrichment Technologies Enhance Simplicity and Efficiency of Obtaining Quality Proteomic Information
- Use On-Bead Digestion to Improve Time Required for Serum Digestion
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