Research Article Cites AlbuVoid™ for Functional Proteomics
MONMOUTH JUNCTION, NJ, June 7, 2016 -- Biotech Support Group reports on a recent research article describing the simplicity and efficiency of their AlbuVoid™ proteomic sample preparation technology for depleting albumin and enriching the low abundance serum proteome from lung cancer samples.
The citation is:
Zhenyu Sun, Xiaofeng Chen, Gan. Wang, Liang Li, Guofeng Fu, Matthew Kuruc and Xing Wang. Identification of functional metabolic biomarkers from lung cancer patient serum using PEP technology. Biomarker Research (2016) 4:11. DOI 10.1186/s40364-016-0065-4
In brief, the article’s authors report a on a functional proteomics top-down method to systematically monitor metabolic enzyme activities in resolved serum proteins produced by a modified 2-D gel separation and subsequent Protein Elution Plate, a method collectively called PEP. The article states “Since most of the functional proteins or enzymes exist at relatively low level in the human serum and there is a limited loading capacity on the 2-DE gel, it is important to enrich the low abundance proteins before 2-DE and PEP analysis. AlbuVoid™ (Biotech Support Group, Monmouth Junction NJ) has been shown to effectively enrich low abundance serum proteins while depleting the Albumin…whereby more functional features were observed with AlbuVoid™ than without…”. The study identified several potential functional enzyme biomarkers from lung cancer patient serum and evidence that the methods provide an alternative and complementary approach to sequence annotation for the discovery of biomarkers in human diseases.
“We are pleased that AlbuVoid™ integrates so well with the PEP platform. Maintaining the integrity of the functional features of proteins is a key feature in all of our enrichment products, as the landscape of protein conformations is highly variable; each conformation contributing to its own unique functional activity. Furthermore, the PEP technology supports great resolving power in functional proteomic studies”, states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.
For more information visit: AlbuVoid™ - Albumin Depletion and Low Abundance Protein Enrichment Kit from Serum, at
About Biotech Support Group LLC
Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com
Dr. Swapan Roy & Matthew Kuruc
Biotech Support Group LLC
1 Deer Park Drive, Suite M
Monmouth Junction NJ 08852
800-935-0628 North America