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Application Report Describes iTRAQ Suitability of Lung and Breast Cancer Serum Samples For New AlbuVoid™ LC-MS On-Bead Product The report describes the differential analysis of breast cancer, lung cancer and normal pooled serum samples. iTRAQ peptide labeling was used to track the relative abundances of 201 total proteins, 21 of which were observed to be differentially expressed in one or both cancer samples. The combined method described in the report shows how low abundance enrichment integrated with on-bead digestion offers many workflow advantages:
The report can be downloaded from the company website at: “I am very pleased that now with our new AlbuVoid™ product for efficient on-bead methods, digestions of serum samples have been shown to be suitable for quantitative proteomics. Convincingly, several of the proteins we differentially observed have also been cited previously, but were observed only after much more onerous workflows.” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.
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