Proteome Enrichment Simplified & Diversified
Advancing precision proteomics through engineered bead-based systems since 2010.
Biotech Support Group has achieved key milestones in proteomic research, pioneering innovative technologies in sub-proteome fractionation, functional proteomics, on-bead digestion, and targeted biomarker quantitation. All of these advances are built on our NRicher™ Bead Chemistry Platform, first introduced in 2010.
Our goal has been to develop proteome subfractionation technologies that do not rely on immuno-affinity, enabling the generation of sub-proteomes with reduced complexity while preserving biological functionality.
The platform supports simple consumable workflows that do not require HPLC or specialized capital equipment, making advanced enrichment more accessible in standard laboratory settings.
Synthetic bead chemistry platform that avoids species-specific antibody dependency.
No specialized instruments required. Standard bind, wash, and elute workflows are enough.
Designed to preserve activity for orthogonal analyses including enzymatic and immunoassay workflows.
Available as general, family-specific, and differentiated multi-bead enrichment formats.
Scientific Progression
From early bead-based fractionation innovation to differentiated sub-proteome enrichment, functional proteomics, and targeted biomarker applications.
Explore the full NRicher™ development story, from pioneering non-immunoaffinity sub-proteome fractionation to functional proteomics, on-bead digestion, targeted enrichment, and emerging proteoform-focused applications.
Started
2010
Original bead-based proteomic fractionation platform
Expanded
2012–2024
Functional workflows, on-bead digestion, family-specific kits
Current focus
2025+
Targeted proteome enrichment and functional proteoform differentiation
Click + to expand the full milestone timeline
From complex biological sample to differentiated sub-proteome output
Optional on-bead digestion or elution workflows for streamlined proteomic analysis.
Maintains compatibility with immunoassay-based workflows after enrichment.
Supports studies where preserved activity and functional integrity matter.
Useful for focused biomarker and family-specific enrichment strategies.
Different NRicher™ chemistries let you move from broad low-abundance enrichment to family-specific and multi-bead differentiated workflows.
Broad enrichment workflow for all biofluids and tissue lysates when you want general low-abundance proteome coverage.
Choose Apo, Ig, or C when your study needs targeted enrichment of apolipoproteins, immunoglobulins, or complement-related proteins.
Use differentiated multi-bead formats when you want to compare binding biases and explore broader sub-proteome resolution.
General Enrichment for All Biofluids and Tissue Lysates
Available sizes: 10 prep, 50 prep
Enrichment of Apolipoproteins
Available sizes: 10 prep, 50 prep
Enrichment of all isotypes and subclasses of Immunoglobulins
Available sizes: 10 prep, 50 prep
Enrichment of Complement Cascade Related Proteins
Available sizes: 10 prep, 50 prep
Differentiated multi-bead enrichment workflow
Available sizes: 5 preps, 25 preps
Differentiated multi-bead enrichment workflow
Available sizes: 5 preps, 25 preps
One platform, multiple enrichment directions
Start with Mx when you want general low-abundance enrichment across many sample types.
Move into Apo, Ig, or C when your biology question is more pathway or protein-family specific.
Use 4SP and 6 formats when you need more exploratory sub-proteome mapping.
Explore how differentiated NRicher™ workflows support targeted biomarker discovery, multiplex proteomics, and broader sub-proteome exploration.
Shows how differentiated bead chemistries create distinct enrichment opportunities for targeted LC-MS quantification.
Read MoreA simplified alternative for researchers seeking species-agnostic enrichment with preserved functional potential.
Explore PlatformTechnical specifications, application reports, and published references that support platform selection and downstream application fit.
Browse PublicationsBrowse case studies, publications, and technical material related to the NRicher™ platform and its differentiated enrichment workflows.
Explore News & EventsOur technical team can help identify the best enrichment strategy for your sample type, target biology, and downstream analytical platform.
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