The GOLD Standard Products
Remove hemoglobin noise to unlock clearer biomarker insights.
Hemoglobin accounting for ≥ 95% of the protein mass in erythrocytes, is often an interfering factor for many types of analysis, both proteinaceous and non-proteinaceous (i.e., PCR). With the rising use of dried blood cards as a cost effective and transportable sample type, analytical interferences from Hemoglobin continues to present problems.
Biotech Support Group's bead-based approach is designed to support sample cleanup and proteomic enrichment without forcing researchers into unnecessarily complex workflows.
The result is a cleaner starting point for discovery, comparative profiling, and downstream biomarker analysis in challenging blood-associated samples.
Reduces dominant hemoglobin interference to reveal low-abundance proteins and improve downstream analytical clarity.
Antibody-free chemistry works across human, mouse, rat, and other species — reliably on hemolyzed serum, whole blood, dried blood spots, RBC lysates, and tissue lysates, where high hemoglobin would otherwise compromise analytical accuracy.
Supports research across neurodegenerative disease, oncology, hemoglobinopathies including sickle cell and thalassemia, malaria, chronic kidney and pulmonary disease, and inflammation-driven biomarker discovery.
A cleaner starting sample leads to more reliable downstream proteomic interpretation
Selective hemoglobin depletion from hemolyzed serum and plasma
Supports LC-MS workflows that benefit from lower background interference
Applies to workflows where cleaner samples improve downstream analytical performance
Useful where strong hemoglobin bands can obscure meaningful signal
Supports cleaner comparative profiling in discovery-focused studies
| Product | Sample Type | Typical Volume | Recommended Applications |
|---|---|---|---|
| HemogloBind™ | Hemolyzed Serum/Plasma, RBC Lysate, Whole Blood Lysate, Tissue Lysates | 25–200 µL | LC-MSWestern BlotImmunoassayFunctional Assays |
| NuGel-HemogloBind™ | Hemolyzed Serum/Plasma | 25–50 µL | LC-MSWestern BlotImmunoassay |
| HemogloBind™ Kit | Hemolyzed Serum/Plasma | 25–200 µL | LC-MSWestern BlotImmunoassay |
| HemogloBind™ Blood Card Kit | Dried Blood Cards | ~10 µL whole blood (7mm hole punch) | LC-MSWestern Blot |
| HemoVoid™ | Red Cell Lysate, Whole Blood Lysate | ~300 µL | LC-MSWestern BlotFunctional Assays |
| HemoVoid™ LC-MS On-Bead | Red Cell Lysate | 100–200 µL | LC-MSSecretome Analysis |
| HemoVoid™ Blood Card Kit | Dried Blood Cards | ~10 µL whole blood (7mm hole punch) | LC-MSWestern Blot |
| HemoVoid™ — Hemoglobin Variant | Red Cell Lysate | ~300 µL | LC-MSWestern BlotFunctional Assays |
Evaluate and compare workflows with small-scale trial kits before scaling your experiments.
Includes:
Best for comparing multiple workflows
Learn MoreIncludes:
Best for depletion-focused validation
Learn MoreRemoves hemoglobin from hemolyzed serum and plasma.
Enhanced hemoglobin capture for complex samples.
Complete kit format for hemoglobin depletion from hemolyzed serum and plasma.
Designed for dried blood spot processing.
Reduces hemoglobin while preserving the proteome.
Direct LC-MS workflow with minimal handling.
Hemoglobin removal from dried blood cards.
Enriches hemoglobin variants from blood.
Compare multiple hemoglobin removal workflows.
Evaluate depletion-focused workflows.
Our proprietary bead technology is suitable for multiple formats and diverse sample types
Convenient processing format for efficient cleanup of challenging samples
Scale up for screening-oriented workflows and efficient batch handling
Flexible option for custom laboratory workflows and larger sample sets
Explore how our hemoglobin removal technologies are used in published studies and advanced proteomics workflows.
Methods demonstrating efficient hemoglobin removal from low-volume dried blood samples for improved downstream analysis.
Read MoreThree proteomic investigations showcasing the role of HemoVoid™ in identifying disease-specific biomarkers.
Read MoreUse of HemoVoid™ and HemogloBind™ for enrichment and analysis of red cells and whole blood samples.
Read MoreExplore the future of clinical proteomics with Biotech Support Group.
Explore Case StudiesOur technical team can help you identify the best hemoglobin removal approach for your sample type, analytical platform, and research goals.
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