PressRelease
Cleanascite™ Cited in Squamous Cell CarcinomaStudy
MONMOUTH JUNCTION, NJ, June 25, 2026 — Biotech Support Group(BSG), a leader in sample preparation, highlights a recent study utilizing itsproprietary lipid removal reagent, Cleanascite™, to investigate lipidinfluences on cancer cell invasion mechanisms.
The study, led by researchers at the Universities and CancerResearch Institutes in the United Kingdom and published in nature metabolism,is titled “Tissue-specific fibroblast lipid cues impose the rate ofepithelial cancer invasion.â€� The research explores how lipid- uptakeor breakdown inhibits oral and lung epithelial cancer invasion.
Squamous cell carcinomas (SCCs) originate in epithelialtissues of older individuals who have been exposed to environmentalcarcinogens. Despite overlapping clinical hallmarks, SCCs from differentanatomic sites have different prognoses. The authors show that fibroblastsconfer site-specific cues that determine SCC proliferation and invasion. Oraland lung fibroblasts have distinct lipid metabolism, transferring unique lipidsto SCC cells that promote epithelial-to-mesenchymal transition, and oral andlung SCC invasion.
Advancing Cancer Research using Cleanacite™
Throughoutthe report, the researchers utilized Cleanascite™ to determine whetherstripping lipids influenced cancer cell response. For example, the articlestates “Cancer cells exploit lipid metabolism, so we tested whether lipidssecreted by fibroblasts drive SCC invasion. For this, we stripped lipids fromfibroblast secretomes with Cleanascite, then exposed SCC spheroids tolipid-stripped secretomes. This established that lipid-stripped oral and lungfibroblast secretomes lost the ability to drive SCC invasion. Importantly,stripping lipids from dermal fibroblast secretomes had no impact on visceralSCC invasion.â€�
The investigation concludes that tissue-resident fibroblastlipids interact with epithelial malignant cells in a tissue-specific manner todetermine SCC invasion. This work provides new therapeutic rationales andtargets for epithelial cancer prevention, biomarker development and cancertherapies.
“Over the last few years, numerous publications have citedCleanascite™ to index cell response by stripping lipids from a wide range ofcellular models of tumor microenvironments,â€� stated Dr. Swapan Roy, Presidentand Founder of Biotech Support Group. “It is rewarding to see our lipid removaltechnology contributing to critical cancer research and potential therapeuticbreakthroughs.â€�
Foradditional product details, visit:
Cleanascite™ Lipid Removal Reagent
About Biotech Support Group LLC
Biotech Support Group develops innovative sample preparation technologies thataddress the emerging needs of proteomics, biomarker discovery, and personalizedmedicine. Flagship products include Cleanascite™ for lipid removal, AlbuVoid™and AlbuSorb™ PLUS for serum protein depletion, HemogloBind™ and HemoVoid™ forhemoglobin removal, and NRicher™for low abundance, family specific, and targeted proteome enrichment.These products support translational research by simplifying workflows andimproving sample quality for downstream analysis.
For Business Development Inquiries:
Matthew Kuruc
Phone: 732-274-2866
Email: [email protected]
Keywords: Cleanascite™, lipid depletion, lipid removal, Squamous cellcarcinoma,Tumor microenvironments, epithelial malignant cells