Press Release

HemogloBind™ Advances Proteomic Study of Temperature Induced Changes to Lung and Intestines

MONMOUTH JUNCTION, NJ, February 17, 2026– A research team from Taipei Medical University, describes HemogloBind™ methods as advantageous in a proteomic comparison of lung and intestinal tissues from mice exposed to high temperature, low temperature, and high-to-low temperature groups. The citation is:

Zakari, Abubakar, et al. "Extreme Temperature Exposure Induces Lung-Gut Dysbiosis in Healthy Mice." Current Research in Microbial Sciences (2026): 100564.

Extreme temperatures caused dysbiosis in lung and gut of mice. This study investigates the impact of extreme temperatures on the lung-gut microbiome and its associated biological pathways in mice. The use of HemogloBind™ was essential to the proteomic comparison. The LC-MS analyses identified 4226 and 4844 proteins in lung and intestine tissue samples, respectively. In comparison to the control group, the study identified 45, 47, and 167 DEPs in lung tissues (Fig. 5A) as well as 716, 19, and 145 DEPs in intestine tissues (Fig. 5B) from high temperature, low temperature, and high-to-low temperature groups, respectively. In addition, 230–708 unique proteins were exclusively detected. Among the DEPs, 157 proteins in lung and 



418 proteins in intestine were commonly identified in all the exposure groups. Distinct proteomic alterations were observed in both tissues under extreme temperature exposure, involving pathways related to metabolism, cellular stress and injury, response to external stimuli, and immune regulation. The study concludes that extreme temperatures altered the proteome profile and pathways in the lung and gut of mice. 

“This is an excellent example of how our Hemoglobin depletion product, HemogloBind™, contributed to differential proteome expression analysis of two different tissues, and that ultimately lead to the conclusions of this study. This shows the versatility of HemogloBind™ as it can be applied across all species and sample types.” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.

For more information on HemogloBind™, visit:

https://www.biotechsupportgroup.com/HemogloBind-Hemoglobin-Depletion-From-Hemolyzed-p/h0145.htm

For more information of all of our Hemoglobin removal products, visit:

https://www.biotechsupportgroup.com/Hemoglobin-Removal-s/312.htm

About Biotech Support Group LLC
Biotech Support Group develops innovative sample preparation technologies that address the emerging needs of proteomics, biomarker discovery, and personalized medicine. Flagship products include Cleanascite™ for lipid removal, AlbuVoid™ and AlbuSorb™ PLUS for serum protein depletion, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NRicher™ for low abundance, family specific, and targeted proteome enrichment. These products support translational research by simplifying workflows and improving sample quality for downstream analysis.

For Business Development Inquiries:
Matthew Kuruc
Phone: 732-274-2866
Email: [email protected]

Keywords: HemogloBind™, Hemoglobin depletion, Hemoglobin removal, lung proteomics, intestinal proteomics, Climate change, extreme temperature exposure, Inflammation