PressRelease
HemogloBind™Advances Proteomic Study of Temperature Induced Changes to Lung andIntestines
MONMOUTHJUNCTION, NJ, February 17, 2026– Aresearch team from Taipei Medical University, describes HemogloBind™methods as advantageous in a proteomic comparison of lung andintestinal tissues from mice exposed to high temperature, lowtemperature, and high-to-low temperature groups. The citation is:
Zakari,Abubakar, et al. "ExtremeTemperature Exposure Induces Lung-Gut Dysbiosis in HealthyMice." CurrentResearch in Microbial Sciences (2026):100564.
Extreme temperatures causeddysbiosis in lung and gut of mice. This studyinvestigates the impact of extreme temperatures on the lung-gutmicrobiome and its associated biological pathways in mice. Theuse of HemogloBind™ wasessential to the proteomic comparison. The LC-MS analyses identified4226 and 4844 proteins in lung and intestine tissue samples,respectively. In comparison to the control group, the studyidentified 45, 47, and 167 DEPs in lung tissues (Fig. 5A) as well as716, 19, and 145 DEPs in intestine tissues (Fig. 5B) from hightemperature, low temperature, and high-to-low temperature groups,respectively. In addition, 230–708 unique proteins were exclusivelydetected. Among the DEPs, 157 proteins in lung and 
418 proteins inintestine were commonly identified in all the exposure groups.Distinct proteomic alterations were observed in both tissues underextreme temperature exposure, involving pathways related tometabolism, cellular stress and injury, response to external stimuli,and immune regulation. The study concludes that extreme temperaturesaltered the proteome profile and pathways in the lung and gut ofmice.
“Thisis an excellent example of how our Hemoglobin depletion product,HemogloBind™, contributed to differential proteome expressionanalysis of two different tissues, and that ultimately lead to theconclusions of this study.This shows the versatility of HemogloBind™ as it can be appliedacross all species and sample types.”statesSwapan Roy, Ph.D., President and Founder of Biotech Support Group.
Formore information on HemogloBind™, visit:
https://www.biotechsupportgroup.com/HemogloBind-Hemoglobin-Depletion-From-Hemolyzed-p/h0145.htm
Formore information of all of our Hemoglobin removal products, visit:
https://www.biotechsupportgroup.com/Hemoglobin-Removal-s/312.htm
AboutBiotech Support Group LLC
BiotechSupport Group develops innovative sample preparation technologiesthat address the emerging needs of proteomics, biomarker discovery,and personalized medicine. Flagship products include Cleanascite™for lipid removal, AlbuVoid™ and AlbuSorb™ PLUS for serum proteindepletion, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NRicher™ for low abundance, family specific, and targetedproteome enrichment.These products support translational research by simplifyingworkflows and improving sample quality for downstream analysis.
ForBusiness Development Inquiries:
Matthew Kuruc
Phone:732-274-2866
Email: [email protected]
Keywords:HemogloBind™, Hemoglobin depletion, Hemoglobin removal, lungproteomics, intestinal proteomics, Climate change, extremetemperature exposure, Inflammation