Press Release

Cleanascite™ Cited in Study of Post-mortem Inter-animal Chemical Signaling

MONMOUTH JUNCTION, NJ, February 17, 2026 — Biotech Support Group (BSG) reports on its proprietary lipid removal reagent, Cleanascite™, in a worm model study of signaling pathways that promote death avoidance, and thus, survival of conspecifics.

In a preprint article led by Coleen T. Murphy at Princeton University, entitled “Caenorhabditis elegans avoids Todstoff, a novel nociceptive necrotaxis cue”, researchers leveraged the nematode Caenorhabditis elegans as it is a powerful system with which to dissect the fundamental molecular biology underpinning both individual and social behaviors due to its highly invariant, stereotyped, and specialized nervous system.

Organisms encounter diverse threats in their environment. In addition to intrinsic mechanisms to tolerate exogenous assault, such as stress and immune pathways, many species have evolved the capacity to recognize and avoid deceased conspecifics. The authors describe a novel gustatory necrotaxis cue, which they term Todstoff (‘death substance’), present in the remains of deceased C. elegans that is distinct from previously-identified worm pheromones and death cues.

To determine what class of biomolecule(s) composes Todstoff, the researchers depleted lipids from daf-22 C. elegans lysate using Cleanascite™, which did not prevent necrotaxis (Figure D, above). In part through the use of Cleanascite™ in this analysis, the authors identified Todstoff as a protein-associated small molecule. Taken together, the work illuminates a novel mode of post-mortem inter-animal chemical communication to promote death avoidance. 

“Here is another excellent example of how Cleanascite™ can be used to clear lipids from a lipid rich tissue such as worm lysates. We now have several references whereby Cleanascite™ was used to determine the biochemical class of a cell response factor and whether it related to lipids.” stated Dr. Swapan Roy, President and Founder of Biotech Support Group.

For additional product details, visit:
Cleanascite™ Lipid Removal Reagent

About Biotech Support Group LLC
Biotech Support Group develops innovative sample preparation technologies that address the emerging needs of proteomics, biomarker discovery, and personalized medicine. Flagship products include Cleanascite™ for lipid removal, AlbuVoid™ and AlbuSorb™ PLUS for serum protein depletion, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NRicher™ for low abundance, family specific, and targeted proteome enrichment. These products support translational research by simplifying workflows and improving sample quality for downstream analysis.

For Business Development Inquiries:
Matthew Kuruc
Phone: 732-274-2866
Email: [email protected]

Keywords: Cleanascite™, lipid depletion, lipid removal, Caenorhabditis elegans, survival of conspecifics, conspecific death avoidance