PressRelease
Cleanascite™Cited in Study of Post-mortem Inter-animal Chemical Signaling
MONMOUTHJUNCTION, NJ, February 17, 2026 — Biotech Support Group (BSG)reports on its proprietary lipid removal reagent, Cleanascite™,in a worm model study of signaling pathways that promote deathavoidance, and thus, survival of conspecifics.
Ina preprint article led by Coleen T. Murphy at Princeton University,entitled “Caenorhabditiselegans avoids Todstoff, a novel nociceptive necrotaxis cue”,researchers leveraged the nematode Caenorhabditis elegans as it is apowerful system with which to dissect the fundamental molecularbiology underpinning both individual and social behaviors due to itshighly invariant, stereotyped, and specialized nervous system.
Organismsencounter diverse threats in their environment. In addition tointrinsic mechanisms to tolerate exogenous assault, such as stressand immune pathways, many species have evolved the capacity torecognize and avoid deceased conspecifics. The authors describe anovel gustatory necrotaxis cue, which they term Todstoff (‘deathsubstance’), present in the remains of deceased C. elegans that isdistinct from previously-identified worm pheromones and death cues.
Todetermine what class of biomolecule(s) composes Todstoff, theresearchers depleted lipids from daf-22 C. elegans lysateusing Cleanascite™, which did not prevent necrotaxis (Figure D,above). In part through the use of Cleanascite™ in this analysis,the authors identified Todstoff as a protein-associated smallmolecule. Taken together, the work illuminates a novel mode ofpost-mortem inter-animal chemical communication to promote deathavoidance.
“Hereis another excellent example of how Cleanascite™ can be used toclear lipids from a lipid rich tissue such as worm lysates. We nowhave several references whereby Cleanascite™ was used to determinethe biochemical class of a cell response factor and whether itrelated to lipids.” stated Dr. Swapan Roy, President and Founder ofBiotech Support Group.
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Cleanascite™Lipid Removal Reagent
AboutBiotech Support Group LLC
BiotechSupport Group develops innovative sample preparation technologiesthat address the emerging needs of proteomics, biomarker discovery,and personalized medicine. Flagship products include Cleanascite™for lipid removal, AlbuVoid™ and AlbuSorb™ PLUS for serum proteindepletion, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NRicher™ for low abundance, family specific, and targetedproteome enrichment.These products support translational research by simplifyingworkflows and improving sample quality for downstream analysis.
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Email: [email protected]
Keywords:Cleanascite™, lipid depletion, lipid removal, Caenorhabditiselegans, survival of conspecifics, conspecific death avoidance