PressRelease
Cleanascite™Cited in Nature Study of Neuronal Proteostasis with Age
MONMOUTH JUNCTION, NJ, January29, 2026 — Biotech Support Group (BSG) reports on itsproprietary lipid removal reagent, Cleanascite™, in a mousemodel study of neuronal protein maintenance and the accumulation ofprotein aggregates with ageing.
In a Nature article led by Tony Wyss-Coray at StanfordUniversity, entitled “Ageingpromotes microglial accumulation of slow-degrading synapticproteins”,researchers leveraged robust in vivo models to examine proteindynamics in a cell-specific manner in mammals. These models were usedto study key features of neuronal proteostasis dynamics with ageingto provide detailed insights into the decline of neuronalproteostasis with age.
Forproteomics of homogenized brain tissue, the article states “Lipidswere removed by the addition of 10 µl Cleanascite per 40 µlhomogenate and incubation with constant agitation on a thermomixerset to 1,500–2,000 rpm for 10 min.”. Upon further bead-basedpulled down, samples were analyzed by Liquid-Chromatrography – MassSpectrometry (LC-MS/MS) for proteomic comparisons and TMT-labeledquantifications.
Inpart through the use of Cleanascite™, combining protein aggregateisolation techniques with neuronal BONCAT labelling helped define theneuronal aggregome, a catalogue of neuronal proteins that contributeto protein aggregates in the aged brain. LC–MS analyses enabledidentification of 1,726 neuronal proteins present in aggregates inthe aged brain, 392 of which have been identified in aggregates ofhuman brains from old individuals. These findings reveal thesubstantial loss of neuronal proteome maintenance with ageing, whichcould be causal for age-related synapse loss and cognitive decline.
“Hereis another excellent example of how Cleanascite™ can be used toclear lipids from a lipid rich tissue such as brain, and that itsexcellent selectivity for removing lipids makes it ideally suited forfurther proteomic analysis by LC-MS/MS.” stated Dr. Swapan Roy,President and Founder of Biotech Support Group.
Foradditional product details, visit:
Cleanascite™Lipid Removal Reagent
AboutBiotech Support Group LLC
BiotechSupport Group develops innovative sample preparation technologiesthat address the emerging needs of proteomics, biomarker discovery,and personalized medicine. Flagship products include Cleanascite™for lipid removal, AlbuVoid™ and AlbuSorb™ PLUS for serum proteindepletion, HemogloBind™ and HemoVoid™ for hemoglobin removal,and NRicher™ for low abundance, family specific, and targetedproteome enrichment.These products support translational research by simplifyingworkflows and improving sample quality for downstream analysis.
ForBusiness Development Inquiries:
Matthew Kuruc
Phone:732-274-2866
Email: [email protected]
Keywords:Cleanascite™, lipid depletion, lipid removal, proteomics, LC-MS/MS,neuronal proteostasis, neurodegenerative disease