Press Release

Cleanascite™ Cited in Nature Study of Neuronal Proteostasis with Age

MONMOUTH JUNCTION, NJ, January 29, 2026 — Biotech Support Group (BSG) reports on its proprietary lipid removal reagent, Cleanascite™, in a mouse model study of neuronal protein maintenance and the accumulation of protein aggregates with ageing.

In a Nature article led by Tony Wyss-Coray at Stanford University, entitled “Ageing promotes microglial accumulation of slow-degrading synaptic proteins”, researchers leveraged robust in vivo models to examine protein dynamics in a cell-specific manner in mammals. These models were used to study key features of neuronal proteostasis dynamics with ageing to provide detailed insights into the decline of neuronal proteostasis with age.

For proteomics of homogenized brain tissue, the article states “Lipids were removed by the addition of 10 µl Cleanascite per 40 µl homogenate and incubation with constant agitation on a thermomixer set to 1,500–2,000 rpm for 10 min.”. Upon further bead-based pulled down, samples were analyzed by Liquid-Chromatrography – Mass Spectrometry (LC-MS/MS) for proteomic comparisons and TMT-labeled quantifications.

In part through the use of Cleanascite™, combining protein aggregate isolation techniques with neuronal BONCAT labelling helped define the neuronal aggregome, a catalogue of neuronal proteins that contribute to protein aggregates in the aged brain. LC–MS analyses enabled identification of 1,726 neuronal proteins present in aggregates in the aged brain, 392 of which have been identified in aggregates of human brains from old individuals. These findings reveal the substantial loss of neuronal proteome maintenance with ageing, which could be causal for age-related synapse loss and cognitive decline.

“Here is another excellent example of how Cleanascite™ can be used to clear lipids from a lipid rich tissue such as brain, and that its excellent selectivity for removing lipids makes it ideally suited for further proteomic analysis by LC-MS/MS.” stated Dr. Swapan Roy, President and Founder of Biotech Support Group.

For additional product details, visit:
Cleanascite™ Lipid Removal Reagent

About Biotech Support Group LLC
Biotech Support Group develops innovative sample preparation technologies that address the emerging needs of proteomics, biomarker discovery, and personalized medicine. Flagship products include Cleanascite™ for lipid removal, AlbuVoid™ and AlbuSorb™ PLUS for serum protein depletion, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NRicher™ for low abundance, family specific, and targeted proteome enrichment. These products support translational research by simplifying workflows and improving sample quality for downstream analysis.

For Business Development Inquiries:
Matthew Kuruc
Phone: 732-274-2866
Email: [email protected]

Keywords: Cleanascite™, lipid depletion, lipid removal, proteomics, LC-MS/MS, neuronal proteostasis, neurodegenerative disease