Press Release

AlbuSorb™ Cited in Proteomic Study of Fish Serum

MONMOUTH JUNCTION, NJ, October 6, 2025– A research article published in Malaysian Applied Biology, highlights AlbuSorb™ as a simple Albumin Removal method in a proteomic study of fish sera. The study from researchers at Universiti Malaya entitled “Pleurotus pulmonarius Stalk Waste Extract Supplementation Modulates Serum Proteins Level in Red Hybrid Tilapia Oreochromis sp. upon PAMPs Challenge” demonstrates the efficiency of Albumin removal using AlbuSorb™.

Utilization of functional feeds to enhance fish health and disease resistance has become common practice in aquaculture. The researchers applied a proteomics approach to examine how mushroom stalk waste extracts modulate fish immunity. This study observed the changes in serum protein levels after supplementation of hot water extract (HWE) of P. pulmonarius mushroom stalk waste in red hybrid tilapia one day after lipopolysaccharide (LPS) and polyinosinic: polycytidylic acid (poly(I:C)) challenge. LPS and poly(I:C) were used to mimic bacterial and viral infections, respectively. After AlbuSorb™ depletion of Albumin, semi-quantitative label-free analysis was used to compare serum proteins of red hybrid tilapia from different experimental diet groups after being challenged with LPS and poly(I:C).

Proteomic analysis revealed differential expression of key immune-related proteins like immunoglobulin µ heavy chain and apolipoprotein A-II, which were significantly higher in the HWE-supplemented group upon LPS challenge. On the other hand, C-type lectin domain-containing protein, immunoglobulin µ heavy chain, hemopexin, serotransferrin, α2-HS-glycoprotein-like, inter-alpha trypsin inhibitor heavy chain H3-like, L-rhamnose-binding lectin, and vitellogenin were lower in the HWE-supplemented diet group as compared to the basal diet group post-poly(I:C) challenge, while plasma protease C1 inhibitor and apolipoprotein Eb increased. These findings suggest that HWE supplementation modulates immune protein expression and enhances disease resilience in tilapia, offering a sustainable strategy for improving aquaculture productivity.

“This reference shows that AlbuSorb™ is very selective for depleting albumin so differentially regulated proteins under challenge conditions can be established.”, states Swapan Roy, Ph.D., President and Founder of Biotech Support Group. “Also, this is another example of how all of our products work for all species, as they do not rely on immuno-affinity.”

For more information visit: AlbuSorb™ at
http://www.biotechsupportgroup.com/AlbuSorb-Albumin-Depletion-Kit-p/a185.htm

For more information on our complete line of Albumin & IgG Removal, visit:

https://www.biotechsupportgroup.com/Albumin-Removal-s/307.htm

About Biotech Support Group LLC
Biotech Support Group develops innovative sample preparation technologies that address the emerging needs of proteomics, biomarker discovery, and personalized medicine. Flagship products include Cleanascite™ for lipid removal, AlbuVoid™ and AlbuSorb™ PLUS for serum protein depletion, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NRicher™ for low abundance, family specific, and targeted proteome enrichment. These products support translational research by simplifying workflows and improving sample quality for downstream analysis.

For Business Development Inquiries:
Matthew Kuruc
Phone: 732-274-2866
Email: [email protected]

Keywords: AlbuSorb™, Albumin depletion, Albumin removal, Functional feed, Pleurotus pulmonarius, fish serum proteomics, red hybrid tilapia