Biotech Support Group to exhibit at the 67th ASMS Conference on Mass Spectrometry & Allied Topics News Release
MONMOUTH
JUNCTION, NJ
, May 2, 2019 -- Biotech Support Group will exhibit at the annual ASMS Conference, June 2-6, 2019 in Atlanta, GA. The American Society for Mass Spectrometry (ASMS) was formed in 1969 to promote and disseminate knowledge of mass spectrometry and allied topics. ASMS sponsors the Annual Conference on Mass Spectrometry and Allied Topics that is attended by more than 6,500 scientists from academic, industrial and governmental laboratories. Over 3,000 papers are presented as posters and talks
Proteomic workflows that support serum proteomics can be especially challenging for two reasons: 1) the presence of highly abundant proteins, Albumin alone accounts for about 50% of the total protein mass, and 2) a particularly proteolytic resistant sample type due the large concentration of antibodies present. Many proteomic enrichment strategies employ the use of immuno-affinity depletion to remove one or more high abundance proteins. Some common limitations of immuno-affinity however are high costs, regeneration requirements which may result in a diminished and inconsistent performance, as well as a required marriage of species to antibody. Because of these limitations, researchers need ways to enrich differently.
The vast majority of the plasma proteome falls into functional categories; by mass content these are: Albumin 50-60%; Immunoglobulins 10-20%; Transport (Transferrin, Apo) 5-10%; Complement related Proteins 3-5%; Protease Inhibitors 2-5%; and all others 2-5%. While these categorical sub-proteomes are required for normal body homeostasis, they nevertheless become dysfunctional during acute-phase and chronic stimuli. As a result, categorically the acute-phase sub-proteomes differentiated in disease may vary greatly from those associated with chronic sub-proteomes. So there is great benefit in having options to enrich or deplete one or more of these sub-proteomes. Herein, we report the serum proteome bias characteristics, both qualitative and quantitative, of the products AlbuVoid™ & NuGel™ Protein A, alone or in serial combination (AlbuVoid™ PLUS), using LC-MS reporting metrics.
With our new data, we have compiled a qualitative and quantitative knowledgebase of over 1000 serum proteins observable by our Albumin depletion products and methods. This knowledgebase will help LC-MS researchers decide which product/method combination may be best for discovery purposes. Likewise, if target proteins are known or suspected, the knowledgebase can guide the researcher towards the best available products/methods for quantitative targeted proteomic analysis. We give an example of how we have used that information in targeted proteomic profiling of cancer sera vs. normal sera differentiation.
Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com.
Matthew
Kuruc 732-274-2866,
mkuruc@biotechsupportgroup.com |
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- Hemoglobin Removal Kits
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- Ectodomain Shedding and Enrichment of the Soluble Membrane Proteome
- Methods to selectively deplete or purify Hemoglobin from Dried Blood Spots (DBS)
- The Utility of HemoVoid™ is Demonstrated in 3 Proteomic Investigations Identifying Potential Disease Specific Biomarkers
- The 4 common features of our sample prep products, known as the BSG Advantage, are highlighted in a selection of journal references.
- AlbuVoid™ Workflows Advance Cell Secretome Proteomics
- Lipid Removal for Phenotypic Cell Response in Cancer Research
- The Influence of Sample Prep Bias on LC-MS Targeted Peptide Quantification in Serum Proteomics
- Re-imagining proteomics for developing precision medicine biomarkers of the innate immune response in SARS-CoV-2
- Patent Application Describes New Proteomic Methods to Monitor Protease Inhibitor Function During Covid-19 Infections
- Efficient Hemoglobin Removal Advances Red Cell Proteomics Offering Many New Insights Into Inflammation and Infectious Disease
- The Potential for New Blood Biomarkers in the Management of COVID-19 Disease
- Establishing the Utility of HemoVoid™ and HemogloBind™ as Enrichment Tools for Proteomic Analysis of Red Cells and Whole Blood in Parkinson’s Disease
- Species Diversity Supported By BSG Products
- Poster Report Describes Loss of Functional Serpin Activity In Cancer Patient Blood
- AlbuVoid™️ PLUS & AlbuSorb™️ PLUS Evaluating Different Windows of Observation Solves The Many Challenges of Serum Proteomics
- Tackling the Challenges of Serum Proteomics
- Lipid Removal Sample Prep for Cell Response Applications
- Sample Prep for Proteomic Analysis of Saliva
- Biotech Support Group Featured in Book, "Functional Proteomics – Methods and Protocols"
- Sample Prep Liquid Biopsy Products Suitable for Proteomic Profiling of a Variety of Body Fluid Sample Types
- Albumin and High Abundance Depletion
- Using HemogloBind™ as a Hemoglobin Binding Reagent
- Diverse technologies available for researchers to selectively bind or enrich exosomes and extracellular vesicles.
- Stroma Liquid Biopsy™ Biomarkers Profile Pan-Cancer Dysregulation of the Serum Proteome
- Diverse Depletion and Enrichment Technologies Enhance Simplicity and Efficiency of Obtaining Quality Proteomic Information
- Use On-Bead Digestion to Improve Time Required for Serum Digestion
- Using AlbuVoid™ as a Serum Protein Enrichment Kit in Functional Proteomics
- Using Cleanascite™ as a Lipid Absorption and Clarification Reagent
- Using HemoVoid to Remove Hemoglobin Before Analysis
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