HemoVoid™ Is A Highly Efficient Hemoglobin Depletion Reagent For Proteomic And Drug Discovery

HemoVoid™ Is A Highly Efficient Hemoglobin Depletion Reagent For Proteomic And Drug Discovery

The challenge in proteome analysis is overcoming the interference by high-abundance proteins obscuring less-abundant proteins. Promising new pathways in hemoglobin research begin to appear as novel molecular diagnostic technology from Biotech Support Group transforms drug discovery by allowing hemoglobin removal from red cell lysates and hemolyzed serum or plasma. Detailed human erythrocyte proteome studies are severely hampered by the presence of hemoglobin, which accounts for more than 98% of the total erythrocyte soluble protein content. HemoVoid™ from Biotech Support Group, is developed with a specific depletion approach that resulted in a drastic increase in the number of identified proteins. This depletion technique may be valuable for proteome studies of human erythrocyte disorders with unknown etiology and of tissue samples that contain blood.

HemoVoid™ derives from a silica-based library of individual mixed-mode ligand combinations. The library is designed to facilitate weak binding of proteins, allowing for rapid elution from the matrix without any foreknowledge of the variety of proteins contained in the starting sample. Also it removes hemoglobin from species including human, sheep, bovine, goat, etc.

With Biotech Support Group’s Hemovoid™, the excess hemoglobin never has to get in the way of your project because precision engineering enables low abundance protein and enzyme enrichment making analysis consistent and reliable . A silica-based protein enrichment matrix, HemoVoid™ has a simple and efficient method. Moreover, increased productivity, reduced process steps, and preservation of native enzyme activity in elution fractions are hallmarks of why HemoVoid7trade; is trusted by researchers. Unlike nickel, HemoVoid™ is easy to use and does not bind hemoglobin. The supernatant which contains mostly hemoglobin is then removed and it can be analyzed further along with the eluted hemoglobin depleted sample. All the eluted hemoglobin depleted sample can be analyzed by enzyme assay, mass spec, 2D gel electrophoresis etc. HemoVoid™ is compatible with single use or high throughput 96 well format. Make the smart choice for your research with HemoVoid™ and discover an evolution in drug discovery and development.