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Stroma Liquid Biopsy

A NEW VIEW OF LIQUID BIOPSY
Stroma Liquid Biopsy - The Next Wave Of Proteomic Profiles For Cancer Biomarkers

While the landscape of cancer-associated DNA mutations has supported the initial concepts for liquid biopsy, it is now overwhelmingly apparent that throughout cancer progression, there are necessary adaptive microenvironments to support metastatic disease. We now present evidence that some of the essential interactions between stroma and proliferating cells can in part, be monitored through the protein response that tracks into the vascularized tumor and re-proportions the extracellular proteins (serum) found in the general blood circulation. These proteomic patterns can now be reported as a Stroma Liquid Biopsy™ which we are launching as a business unit called Rakta.


Is there a common systemic response to cancer? Coagulation, Complement Cascade, Acute Phase Inflammation

Our commercial goal is to associate this knowledge and data to establish relationships with client supplied samples characterized for progressive disease or response to therapies, ultimately achieving biomarkers useful in the clinic. We achieve these goals through partnerships and collaborations in the oncology field, but the discovery patterns can be applied to other disease pathologies.




Seed & Soil

  • Heterogeneous nature of cancer’s DNA
  • Research the stroma
  • Analyze tumor-associated microenvironment
  • Find genomic and proteomic evidence
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Needle In The Haystack

  • Stroma and proliferating cells interactions
  • Measure cancer stages
  • Discover biomarker proteins
  • Monitor cancer
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IP Supports Many New Cancer Management Strategies

  • Analyze Coagulation
  • Evaluate Complement in cancer ecosystem
  • Track Acute-phase Inflammation
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IP Supports Proteome Dysregulation In Cancer

  • Rakta Protein Code
  • Analyze signal intensity
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Cancer Targets

  • Stroma immune modulators
  • Stroma Liquid Biopsy™ biomarker panel
  • Personalized Medicine
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IP Scope Is Vast

  • Coagulation
  • Complement
  • Acute Phase Inflammation
  • Personalized Medicine
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The Proteogenomic Goal

  • Research protease inhibitors
  • Research SERPIN inhibitors
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SERPIN Dysregulation in Cancer

  • Discover active & inactive SERPIN sub-populations
  • Partnerships and collaborations in the oncology field on protease, SERPINs and cancer.
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References

1.Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674.


2.Quail, DF., and JA Joyce. Microenvironmental regulation of tumor progression and metastasis. Nature medicine 19.11 (2013): 1423-1437.


3.Zheng H, Zhao C, Roy S, et al. The Comparison of the Serum Proteome in Individuals with Cancers versus those without Cancer, and its application to Wellness. Poster reprint from 12th Annual US HUPO 2016 Conference, held March 13 – 16, 2016 Boston, MA, USA.


4.Zheng H, Zhao C, Roy S, et al. The Commonality of the Cancer Serum Proteome Phenotype as analyzed by LC-MS/MS, and Its Application to Monitor Dysregulated Wellness. Poster reprint from AACR Annual Meeting 2016 Conference, held April 17-20, 2016 New Orleans, LA USA

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